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Appendix to paper by J.K.R. Savage. Radiation induced chromosomal aberrations in the plant Tradescantia. Dose-response curves.\" 81 (1975)","DOI":"10.1016\/S0033-7560(75)80001-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"J Hertveldt, H Philippe, K. 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