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Durbin,  \"The chemistry of the actinide and transactinide elements. Vol. 5.\"  , \"Actinides in animals and man.\" 3339 (2006)","DOI":"10.1007\/1-4020-3598-5_31"},{"key":"3","unstructured":"MH Bhattacharyya, BD Breitenstein, H Metivier, et al.  \"Radiat Prot Dosim.\"  41, \"Guidebook for the treatment of accidental internal radionuclide contamination of workers.\" 1 (1992)"},{"key":"4","doi-asserted-by":"crossref","unstructured":"F Menetrier, L Grappin, P Raynaud, et al.  \"Appl Radiat Isot.\"  62, \"Treatment of accidental intakes of plutonium and americium: guidance notes.\" 829 (2005)","DOI":"10.1016\/j.apradiso.2005.01.005"},{"key":"5","unstructured":"et al.  \"Highlights of prescribing information: Pentetate zinc trisodium (Zn-DTPA) for intravenous and inhalation administration.\"  ,  (2004)"},{"key":"8","doi-asserted-by":"crossref","unstructured":"RA Guilmette, ES Moretti, A Lindenbaum,  \"Radiat Res.\"  78, \"Toward an optimal DTPA therapy for decorporation of actinides: time-dose relationships for plutonium in the dog. I.\" 415 (1979)","DOI":"10.2307\/3574969"},{"key":"9","doi-asserted-by":"crossref","unstructured":"RD Lloyd, CW Jones, GN Taylor, et al.  \"Radiat Res.\"  79, \"Pu and Am decorporation in beagles: effects of magnitude of initial Ca-DTPA injection upon chelation efficacy.\" 630 (1979)","DOI":"10.2307\/3575187"},{"key":"10","doi-asserted-by":"crossref","unstructured":"RD Lloyd, GN Taylor, CW Mays, et al.  \"Radiat Res.\"  78, \"Dependency of chelation efficacy upon time after first DTPA injection.\" 448 (1979)","DOI":"10.2307\/3574971"},{"key":"11","unstructured":"et al.  \"Notice: Ca-DTPA 250 mg\/mL, solution injectable Pentetate de calcium trisodique.\"  ,  ()"},{"key":"12","doi-asserted-by":"crossref","unstructured":"R Ducousso, E Girerd, C Pasquier,  \"Radioprotection.\"  9, \"Traitement d'urgence des radiocontaminations respiratoires: g\u00e9n\u00e9rateurs autonomes d'aerosols de DTPA.\" 173 (1974)","DOI":"10.1051\/radiopro\/19740903173"},{"key":"13","doi-asserted-by":"crossref","unstructured":"H Tymen, D Schoulz, A Caire-Maurisier, et al.  \"Radioprotection.\"  35, \"Traitement d'urgence des contaminations internes par les transuraniens. Une nouvelle forme galenique du Na3Ca-DTPA micronise.\" 473 (2000)","DOI":"10.1051\/radiopro:2000116"},{"key":"14","unstructured":"L Grappin, P Berard, P Beau, et al.  \"Exposition aux actinides: bilan injections de Ca-DTPA dans les centres CEA-COGEMA. Rapport CEA-R-6097, ISSN 0429-3460.\"  ,  (2006)"},{"key":"15","doi-asserted-by":"crossref","unstructured":"JC Nenot, M Morin, J Lafuma,  \"Health Phys.\"  20, \"Experimental contaminations with americium solutions and their treatment.\" 383 (1971)","DOI":"10.1097\/00004032-197104000-00003"},{"key":"16","doi-asserted-by":"crossref","unstructured":"JC Nenot, M Morin, J Lafuma,  \"Health Phys.\"  20, \"Metabolic and therapeutic study of respiratory contamination by various actinic solutions.\" 167 (1971)","DOI":"10.1097\/00004032-197102000-00005"},{"key":"17","unstructured":"JW Stather, H Smith, AC James, et al.  \"Diagnoses and treatment of incorporated radionuclides. International Atomic Energy Agency.\"  , \"The experimental use of aerosol and liposomal forms of Ca-DTPA as a treatment for plutonium contamination.\"  (1976)"},{"key":"18","unstructured":"GN Stradling, JW Stather, SE Ham, et al.  \"Health Phys.\"  41, \"The use of Puchel and DTPA for removing 238PuO2 from the lungs of hamsters.\" 387 (1981)"},{"key":"19","unstructured":"JW Stather, GN Stradling, H Smith, et al.  \"Health Phys.\"  42, \"Decorporation of 238PuO2 from the hamster by inhalation of chelating agents.\" 520 (1982)"},{"key":"20","unstructured":"GN Stradling, JW Stather, SA Sumner, et al.  \"Health Phys.\"  46, \"Decorporation of inhaled americium-241 dioxide and nitrate from hamsters using ZnDTPA and Puchel.\" 1296 (1984)"},{"key":"21","doi-asserted-by":"crossref","unstructured":"JW Stather, GN Stradling, SA Gray, et al.  \"Hum Toxicol.\"  4, \"Use of DTPA for increasing the rate of elimination of plutonium-238 and americium-241 from rodents after their inhalation as the nitrates.\" 573 (1985)","DOI":"10.1177\/096032718500400603"},{"key":"22","doi-asserted-by":"crossref","unstructured":"O Gremy, N Tsapis, S Bruel, et al.  \"Radiat Res.\"  178, \"Decorporation approach following rat lung contamination with a moderately soluble compound of plutonium using local and systemic Ca-DTPA combined chelation.\" 217 (2012)","DOI":"10.1667\/RR2866.1"},{"key":"23","doi-asserted-by":"crossref","unstructured":"O Gremy, N Tsapis, Q Chau, et al.  \"Radiat Res.\"  174, \"Preferential decorporation of americium by pulmonary administration of DTPA dry powder after inhalation of aged PuO(2) containing americium in rats.\" 637 (2010)","DOI":"10.1667\/RR2203.1"},{"key":"24","doi-asserted-by":"crossref","unstructured":"S Chen, EPC Lai, R Ko, et al.  \"Nanomed Nanotechnol.\"  1, \"Inhalable chitosan tripolyphosphate nanoparticles for extended release of DTPA into lung fluid.\" 000106 (2016)","DOI":"10.23880\/NNOA-16000106"},{"key":"25","doi-asserted-by":"crossref","unstructured":"A Van der Meeren, O Gremy, D Renault, et al.  \"J Radiat Res.\"  53, \"Plutonium behavior after pulmonary administration according to solubility properties, and consequences on alveolar macrophage activation.\" 184 (2012)","DOI":"10.1269\/jrr.11112"},{"key":"26","doi-asserted-by":"crossref","unstructured":"W. Sontag,  \"Int J Radiat Biol.\"  60, \"Microdistribution of 239Pu in the rat skeleton. Part I. Dose dependency.\" 677 (1991)","DOI":"10.1080\/09553009114552491"},{"key":"27","doi-asserted-by":"crossref","unstructured":"L Grappin  and P Berard  \"Radioprotection.\"  43, \"Autorisation de mise sur le marche du Ca-DTPA.\" 465 (2008)","DOI":"10.1051\/radiopro:2008047"},{"key":"28","doi-asserted-by":"crossref","unstructured":"FE Crawley  and JW Haines  \"Int J Nucl Med Biol.\"  6, \"The dosimetry of carbon-14 labelled compounds: the metabolism of diethylenetriamine pentaacetic acid (DTPA) in the rat.\" 9 (1979)","DOI":"10.1016\/0047-0740(79)90061-5"},{"key":"29","unstructured":"GN Stradling, JW Stather, SA Sumner, et al.  \"Health Phys.\"  46, \"Decorporation of inhaled plutonium nitrate from hamsters using Zn-DTPA.\" 919 (1984)"},{"key":"30","doi-asserted-by":"crossref","unstructured":"R Mehri, W Tang, EA Matida, et al.  \"J Aerosol Med Pulm Drug Deliv.\"  31, \"Aerosolization of ZnDTPA decorporation agent using jet and ultrasonic nebulizers.\" 311 (2018)","DOI":"10.1089\/jamp.2017.1419"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2019,12,31]],"date-time":"2019-12-31T12:24:45Z","timestamp":1577795085000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-192\/issue-6\/RR15451.1\/Chelation-Treatment-by-Early-Inhalation-of-Liquid-Aerosol-DTPA-for\/10.1667\/RR15451.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,23]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,12,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rr15451.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9,23]]}}}