{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:34:33Z","timestamp":1793446473973,"version":"4.5.0"},"reference-count":43,"publisher":"Radiation Research Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2020,6,18]]},"abstract":"<jats:p>The findings from previously published studies have suggested that radiation exposure is associated with increased mortality and incidence of gastric cancer. However, few cohort studies have incorporated risk factors such as Helicobacter pylori (H. pylori) infection or chronic atrophic gastritis (CAG). The current study is aimed at evaluating the modifying effect of CAG on radiation risk of noncardia gastric cancer by histological type, by reanalyzing data from a nested case\u2013control study conducted within the longitudinal clinical cohort of atomic bomb survivors. The analysis was restricted to 297 intestinal- or diffuse-type noncardia cases and 873 controls rematched to the cases on gender, age, city, and time and type of serum storage, and countermatched on radiation dose. Multivariable-adjusted relative risks [95% confidence interval (CI)] of noncardia gastric cancer were 3.9 (2.1\u20137.2) for H. pylori IgG seropositivity with cytotoxin-associated gene A (CagA) IgG low titer, 2.6 (1.9\u20133.6) for CAG, 1.9 (1.3\u20132.8) for current smoking, and 1.4 (1.1\u20131.9) for 1 Gy irradiation. Among subjects without CAG, the relative risk (95% CI) of noncardia gastric cancer at 1 Gy was 2.3 (1.4\u20133.7), whereas relative risk (95% CI) at 1 Gy was 1.1 (0.8\u20131.5) among subjects with CAG (for the overall interaction, P = 0.012). By histological type, the risk at 1 Gy was high for diffuse type without CAG, with adjusted relative risk (95% CI) of 3.8 (2.0\u20137.6), but was not high for diffuse type with CAG or for intestinal-type irrespective of CAG status. The results indicate that radiation exposure is associated with increased risk of diffuse-type noncardia gastric cancer without CAG, and this association exists despite adjustment for H. pylori infection and smoking habit.<\/jats:p>","DOI":"10.1667\/rr15482.1","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T02:51:07Z","timestamp":1595991067000},"page":"180-187","source":"Crossref","is-referenced-by-count":1,"title":["Modifying Effect of Chronic Atrophic Gastritis on Radiation Risk for Noncardia Gastric Cancer According to Histological Type"],"prefix":"10.1667","volume":"194","author":[{"given":"Keiko","family":"Ueda","sequence":"first","affiliation":[{"name":"Departments of  Clinical Studies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waka","family":"Ohishi","sequence":"additional","affiliation":[{"name":"Departments of  Clinical Studies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Cullings","sequence":"additional","affiliation":[{"name":"Departments of   Statistics, Radiation Effects Research Foundation, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeko","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Departments of  Clinical Studies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Departments of   International University of Health and Welfare Clinic, Ohtawara, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Molecular Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fukiko","family":"Mitsui","sequence":"additional","affiliation":[{"name":"Departments of  Clinical Studies"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Hida","sequence":"additional","affiliation":[{"name":"Department of Clinical Studies, Radiation Effects Research Foundation, Nagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Ozasa","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuaki","family":"Chayama","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism, Applied Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Tahara","sequence":"additional","affiliation":[{"name":"Departments of   Hiroshima Cancer Seminar Foundation, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"21","doi-asserted-by":"publisher","unstructured":"DL Preston, E Ron, S Tokuoka, et al.  \"Radiat Res.\"  168, \"Solid cancer incidence in atomic bomb survivors: 1958\u20131998.\" 1 (2007)","DOI":"10.1667\/RR0763.1"},{"key":"20","doi-asserted-by":"crossref","unstructured":"K Ozasa, Y Shimizu, A Suyama, et al.  \"Radiat Res.\"  177, \"Studies of the mortality of atomic bomb survivors, Report 14, 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VanderWeele,  \"Explanation in causal inference: Methods for mediation and interaction.\"  , 268 (2015)","DOI":"10.1093\/ije\/dyw277"},{"key":"29","doi-asserted-by":"crossref","unstructured":"HM Cullings, S Fujita, S Funamoto, et al.  \"Radiat Res.\"  166, \"Dose estimation for atomic bomb survivor studies: its evolution and present status.\" 219 (2006)","DOI":"10.1667\/RR3546.1"},{"key":"8","doi-asserted-by":"crossref","unstructured":"LM Morton, GM Dores, RE Curtis, et al.  \"J Clin Oncol.\"  31, \"Stomach cancer risk after treatment for Hodgkin lymphoma.\" 3369 (2013)","DOI":"10.1200\/JCO.2013.50.6832"},{"key":"6","doi-asserted-by":"crossref","unstructured":"M Hauptmann, SD Fossa, M Stovall, et al.  \"Br J Cancer.\"  112, \"Increased stomach cancer risk following radiotherapy for testicular cancer.\" 44 (2015)","DOI":"10.1038\/bjc.2014.552"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:28:43Z","timestamp":1793446123000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-194\/issue-2\/RR15482.1\/Modifying-Effect-of-Chronic-Atrophic-Gastritis-on-Radiation-Risk-for\/10.1667\/RR15482.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,18]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,8,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rr15482.1","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,18]]}}}