{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:36:03Z","timestamp":1771014963855,"version":"3.50.1"},"reference-count":66,"publisher":"Radiation Research Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2009,10,1]]},"DOI":"10.1667\/rr1603.1","type":"journal-article","created":{"date-parts":[[2009,9,23]],"date-time":"2009-09-23T00:19:27Z","timestamp":1253665167000},"page":"463","source":"Crossref","is-referenced-by-count":6,"title":["Chk2 Protects against Radiation-Induced Genomic Instability"],"prefix":"10.1667","volume":"172","author":[{"given":"Ann","family":"MacLaren","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Slavin","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare H.","family":"McGowan","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and, The Scripps Research Institute, La Jolla, California 92037"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1243","reference":[{"key":"i0033-7587-172-4-463-b01","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/35044005","volume":"408","author":"Zhou B. B.","year":"2000","journal-title":"Nature"},{"key":"i0033-7587-172-4-463-b02","doi-asserted-by":"publisher","DOI":"10.1038\/35103059"},{"key":"i0033-7587-172-4-463-b03","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1535-6108(03)00110-7","volume":"3","author":"Bartek J.","year":"2003","journal-title":"Cancer Cell"},{"key":"i0033-7587-172-4-463-b04","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5395.1893"},{"key":"i0033-7587-172-4-463-b05","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-9822(99)80041-4","volume":"9","author":"Blasina A.","year":"1999","journal-title":"Curr. Biol"},{"key":"i0033-7587-172-4-463-b06","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1126\/science.287.5459.1824","volume":"287","author":"Hirao A.","year":"2000","journal-title":"Science"},{"key":"i0033-7587-172-4-463-b07","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/35036406","volume":"2","author":"Melchionna R.","year":"2000","journal-title":"Nat. Cell Biol"},{"key":"i0033-7587-172-4-463-b08","doi-asserted-by":"crossref","first-page":"3745","DOI":"10.1073\/pnas.96.7.3745","volume":"96","author":"Brown A. L.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"i0033-7587-172-4-463-b09","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.277.5331.1501","volume":"277","author":"Peng C. Y.","year":"1997","journal-title":"Science"},{"key":"i0033-7587-172-4-463-b10","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1126\/science.277.5331.1497","volume":"277","author":"Sanchez Y.","year":"1997","journal-title":"Science"},{"key":"i0033-7587-172-4-463-b11","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1128\/MCB.21.13.4129-4139.2001","volume":"21","author":"Zhao H.","year":"2001","journal-title":"Mol. Cell. Biol"},{"key":"i0033-7587-172-4-463-b12","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1101\/gad.14.12.1439","volume":"14","author":"Takai H.","year":"2000","journal-title":"Genes Dev"},{"key":"i0033-7587-172-4-463-b13","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.1128\/MCB.22.18.6521-6532.2002","volume":"22","author":"Hirao A.","year":"2002","journal-title":"Mol. Cell. Biol"},{"key":"i0033-7587-172-4-463-b14","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdf506"},{"key":"i0033-7587-172-4-463-b15","doi-asserted-by":"crossref","first-page":"20480","DOI":"10.1074\/jbc.M213185200","volume":"278","author":"Ahn J.","year":"2003","journal-title":"J. Biol. Chem"},{"key":"i0033-7587-172-4-463-b16","doi-asserted-by":"crossref","first-page":"20475","DOI":"10.1074\/jbc.M213159200","volume":"278","author":"Jallepalli P. V.","year":"2003","journal-title":"J. Biol. Chem"},{"key":"i0033-7587-172-4-463-b17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature03098","volume":"432","author":"Lowe S. W.","year":"2004","journal-title":"Nature"},{"key":"i0033-7587-172-4-463-b18","doi-asserted-by":"publisher","DOI":"10.1038\/nature03482"},{"key":"i0033-7587-172-4-463-b19","doi-asserted-by":"publisher","DOI":"10.1038\/nature03485"},{"key":"i0033-7587-172-4-463-b20","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nature05327","volume":"444","author":"Di Micco R.","year":"2006","journal-title":"Nature"},{"key":"i0033-7587-172-4-463-b21","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nm1087","volume":"10","author":"Vogelstein B.","year":"2004","journal-title":"Nat. Med"},{"key":"i0033-7587-172-4-463-b22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/356215a0","volume":"356","author":"Donehower L. A.","year":"1992","journal-title":"Nature"},{"key":"i0033-7587-172-4-463-b23","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/342705a0","volume":"342","author":"Nigro J. M.","year":"1989","journal-title":"Nature"},{"key":"i0033-7587-172-4-463-b24","first-page":"1699","volume":"6","author":"Bartek J.","year":"1991","journal-title":"Oncogene"},{"key":"i0033-7587-172-4-463-b25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","volume":"4","author":"Jacks T.","year":"1994","journal-title":"Curr. Biol"},{"key":"i0033-7587-172-4-463-b26","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80086-0"},{"key":"i0033-7587-172-4-463-b27","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.19.2411"},{"key":"i0033-7587-172-4-463-b28","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrc1011","volume":"3","author":"Shiloh Y.","year":"2003","journal-title":"Nat. Rev"},{"key":"i0033-7587-172-4-463-b29","first-page":"704","volume":"163","author":"Lavin M. F.","year":"2005","journal-title":"Radiat. Res"},{"key":"i0033-7587-172-4-463-b30","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1126\/science.286.5449.2528","volume":"286","author":"Bell D. W.","year":"1999","journal-title":"Science"},{"key":"i0033-7587-172-4-463-b31","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1038\/sj.onc.1209877","volume":"25","author":"Nevanlinna H.","year":"2006","journal-title":"Oncogene"},{"key":"i0033-7587-172-4-463-b32","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/nrc2251","volume":"7","author":"Antoni L.","year":"2007","journal-title":"Nat. Rev"},{"key":"i0033-7587-172-4-463-b33","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1126\/science.1094557","volume":"304","author":"McPherson J. P.","year":"2004","journal-title":"Science"},{"key":"i0033-7587-172-4-463-b34","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/sj.emboj.7601115","volume":"25","author":"Cao L.","year":"2006","journal-title":"EMBO J"},{"key":"i0033-7587-172-4-463-b35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.molcel.2008.04.028","volume":"31","author":"Stracker T. H.","year":"2008","journal-title":"Mol. Cell"},{"key":"i0033-7587-172-4-463-b36","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.4161\/cc.7.23.7064","volume":"7","author":"Stracker T. H.","year":"2008","journal-title":"Cell Cycle"},{"key":"i0033-7587-172-4-463-b37","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/jmg.2006.044974","volume":"43","author":"Cybulski C.","year":"2006","journal-title":"J. Med. Genet"},{"key":"i0033-7587-172-4-463-b38","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1158\/0008-5472.CAN-05-1237","volume":"66","author":"Kwak E. L.","year":"2006","journal-title":"Cancer Res"},{"key":"i0033-7587-172-4-463-b39","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1182\/blood-2002-04-1078","volume":"100","author":"Tort F.","year":"2002","journal-title":"Blood"},{"key":"i0033-7587-172-4-463-b40","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.1128\/MCB.25.17.7569-7579.2005","volume":"25","author":"Dendouga N.","year":"2005","journal-title":"Mol. Cell. Biol"},{"key":"i0033-7587-172-4-463-b41","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1073\/pnas.87.8.3132","volume":"87","author":"Tlsty T. D.","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"i0033-7587-172-4-463-b42","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/0092-8674(90)90409-8","volume":"63","author":"Scheffner M.","year":"1990","journal-title":"Cell"},{"key":"i0033-7587-172-4-463-b43","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/nar\/gki168","volume":"33","author":"Pascucci B.","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"i0033-7587-172-4-463-b44","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1128\/MCB.20.11.3977-3987.2000","volume":"20","author":"Strumberg D.","year":"2000","journal-title":"Mol. Cell. Biol"},{"key":"i0033-7587-172-4-463-b45","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1101\/gad.12.18.2956","volume":"12","author":"Desany B. A.","year":"1998","journal-title":"Genes Dev"},{"key":"i0033-7587-172-4-463-b46","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1101\/gad.12.3.382","volume":"12","author":"Lindsay H. D.","year":"1998","journal-title":"Genes Dev"},{"key":"i0033-7587-172-4-463-b47","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1126\/science.280.5365.909","volume":"280","author":"Boddy M. N.","year":"1998","journal-title":"Science"},{"key":"i0033-7587-172-4-463-b48","doi-asserted-by":"publisher","DOI":"10.1021\/cr040478b"},{"key":"i0033-7587-172-4-463-b49","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","volume":"3","author":"Longley D. B.","year":"2003","journal-title":"Nat. Rev"},{"key":"i0033-7587-172-4-463-b50","doi-asserted-by":"crossref","first-page":"30814","DOI":"10.1074\/jbc.M603747200","volume":"281","author":"Takemura H.","year":"2006","journal-title":"J. Biol. Chem"},{"key":"i0033-7587-172-4-463-b51","doi-asserted-by":"crossref","first-page":"5775","DOI":"10.1038\/sj.emboj.7601446","volume":"25","author":"Stiff T.","year":"2006","journal-title":"EMBO J"},{"key":"i0033-7587-172-4-463-b52","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1101\/gad.13.7.768","volume":"13","author":"de Laat W. L.","year":"1999","journal-title":"Genes Dev"},{"key":"i0033-7587-172-4-463-b53","doi-asserted-by":"crossref","first-page":"10058","DOI":"10.1073\/pnas.0502311102","volume":"102","author":"Besaratinia A.","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"i0033-7587-172-4-463-b54","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/toxsci\/kfj161","volume":"91","author":"Arima Y.","year":"2006","journal-title":"Toxicol. Sci"},{"key":"i0033-7587-172-4-463-b55","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/carcin\/6.4.555","volume":"6","author":"Mirzayans R.","year":"1985","journal-title":"Carcinogenesis"},{"key":"i0033-7587-172-4-463-b56","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.mrfmmm.2003.06.002","volume":"531","author":"Slupphaug G.","year":"2003","journal-title":"Mutat. Res"},{"key":"i0033-7587-172-4-463-b57","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/978-1-4615-9376-8_19","volume":"172","author":"Wahl G. M.","year":"1984","journal-title":"Adv. Exp. Med. Biol"},{"key":"i0033-7587-172-4-463-b58","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1073\/pnas.94.5.1816","volume":"94","author":"Smith K. A.","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"i0033-7587-172-4-463-b59","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90243-6"},{"key":"i0033-7587-172-4-463-b60","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S1568-7864(02)00035-6","volume":"1","author":"Mondello C.","year":"2002","journal-title":"DNA Repair"},{"key":"i0033-7587-172-4-463-b61","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80416-X"},{"key":"i0033-7587-172-4-463-b62","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1101\/gad.14.3.278","volume":"14","author":"Chehab N. H.","year":"2000","journal-title":"Genes Dev"},{"key":"i0033-7587-172-4-463-b63","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1038\/sj.emboj.7601032","volume":"25","author":"LeBron C.","year":"2006","journal-title":"EMBO J"},{"key":"i0033-7587-172-4-463-b64","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1128\/MCB.18.5.3089","volume":"18","author":"Paulson T. G.","year":"1998","journal-title":"Mol. Cell. Biol"},{"key":"i0033-7587-172-4-463-b65","doi-asserted-by":"crossref","first-page":"6314","DOI":"10.1073\/pnas.0802080105","volume":"105","author":"Hastak K.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"i0033-7587-172-4-463-b66","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1038\/nature05077","volume":"443","author":"Christophorou M. A.","year":"2006","journal-title":"Nature"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T18:10:49Z","timestamp":1710612649000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-172\/issue-4\/RR1603.1\/Chk2-Protects-against-Radiation-Induced-Genomic-Instability\/10.1667\/RR1603.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,1]]},"references-count":66,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2009,10,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rr1603.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10,1]]}}}