{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T20:51:55Z","timestamp":1778187115000,"version":"3.51.4"},"reference-count":46,"publisher":"Radiation Research Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2011,4,8]]},"DOI":"10.1667\/rr2462.1","type":"journal-article","created":{"date-parts":[[2011,4,8]],"date-time":"2011-04-08T23:17:45Z","timestamp":1302304665000},"page":"746","source":"Crossref","is-referenced-by-count":34,"title":["A TPO Receptor Agonist, ALXN4100TPO, Mitigates Radiation-Induced Lethality and Stimulates Hematopoiesis in CD2F1 Mice"],"prefix":"10.1667","volume":"175","author":[{"given":"Merriline","family":"Satyamitra","sequence":"first","affiliation":[{"name":"Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University, Bethesda, Maryland 20889"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Lombardini","sequence":"additional","affiliation":[{"name":"Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University, Bethesda, Maryland 20889"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Graves","sequence":"additional","affiliation":[{"name":"Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University, Bethesda, Maryland 20889"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Conor","family":"Mullaney","sequence":"additional","affiliation":[{"name":"Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University, Bethesda, Maryland 20889"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Ney","sequence":"additional","affiliation":[{"name":"Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University, Bethesda, Maryland 20889"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Hunter","sequence":"additional","affiliation":[{"name":"Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krista","family":"Johnson","sequence":"additional","affiliation":[{"name":"Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Tamburini","sequence":"additional","affiliation":[{"name":"Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy P.","family":"Springhorn","sequence":"additional","affiliation":[{"name":"Alexion Pharmaceuticals, Inc., 352 Knotter Drive, Cheshire, Connecticut 06410"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkataraman","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Armed Forces Radiobiology Research Institute (AFRRI), Uniformed Services University, Bethesda, Maryland 20889"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1243","reference":[{"key":"i0033-7587-175-6-746-b01","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.2307\/3577994","volume":"128","author":"van Bekkum D. W.","year":"1991","journal-title":"Radiat Res"},{"key":"i0033-7587-175-6-746-b02","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1667\/RR3276","volume":"162","author":"Stone H. B.","year":"2004","journal-title":"Radiat Res"},{"key":"i0033-7587-175-6-746-b03","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095956"},{"key":"i0033-7587-175-6-746-b04","doi-asserted-by":"publisher","DOI":"10.1080\/09553000310001642920"},{"key":"i0033-7587-175-6-746-b05","doi-asserted-by":"publisher","DOI":"10.1080\/09553000902985144"},{"key":"i0033-7587-175-6-746-b06","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1126\/science.276.5319.1696","volume":"276","author":"Cwirla S. E.","year":"1997","journal-title":"Science"},{"key":"i0033-7587-175-6-746-b07","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1046\/j.1365-2141.1996.d01-1842.x","volume":"94","author":"Akahori H.","year":"1996","journal-title":"Br J Haematol"},{"key":"i0033-7587-175-6-746-b08","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118652"},{"key":"i0033-7587-175-6-746-b09","first-page":"1238","volume":"24","author":"Grossmann A.","year":"1996","journal-title":"Exp Hematol"},{"key":"i0033-7587-175-6-746-b10","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1182\/blood.V86.12.4486.bloodjournal86124486","volume":"86","author":"Hokom M. M.","year":"1995","journal-title":"Blood"},{"key":"i0033-7587-175-6-746-b11","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1172\/JCI118210","volume":"96","author":"Kaushansky K.","year":"1995","journal-title":"J Clin Invest"},{"key":"i0033-7587-175-6-746-b12","first-page":"265","volume":"24","author":"Kaushansky K.","year":"1996","journal-title":"Exp Hematol"},{"key":"i0033-7587-175-6-746-b13","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1182\/blood.V100.10.3457","volume":"100","author":"Kuter D. J.","year":"2002","journal-title":"Blood"},{"issue":"4","key":"i0033-7587-175-6-746-b14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0037-1963(00)90047-7","volume":"37","author":"McCullough J.","year":"2000","journal-title":"Semin Hematol"},{"key":"i0033-7587-175-6-746-b15","doi-asserted-by":"crossref","first-page":"4607","DOI":"10.1182\/blood-2006-10-019315","volume":"109","author":"Kuter D. J.","year":"2007","journal-title":"Blood"},{"key":"i0033-7587-175-6-746-b16","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1182\/blood.V98.12.3241","volume":"98","author":"Li J.","year":"2001","journal-title":"Blood"},{"issue":"4","key":"i0033-7587-175-6-746-b17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0037-1963(00)90050-7","volume":"37","author":"Vadhan-Raj S.","year":"2000","journal-title":"Semin Hematol"},{"key":"i0033-7587-175-6-746-b18","doi-asserted-by":"crossref","first-page":"S347","DOI":"10.3816\/CLM.2009.s.034","volume":"9","author":"Kuter D. J.","year":"2009","journal-title":"Clin Lymphoma Myeloma"},{"key":"i0033-7587-175-6-746-b19","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/stem.170316","volume":"17","author":"de Serres M.","year":"1999","journal-title":"Stem Cells"},{"key":"i0033-7587-175-6-746-b20","doi-asserted-by":"crossref","first-page":"14307","DOI":"10.1073\/pnas.0602658103","volume":"103","author":"Frederickson S.","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"i0033-7587-175-6-746-b21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3233\/HAB-2007-163-404","volume":"16","author":"Wild M. A.","year":"2007","journal-title":"Hum Antibodies"},{"key":"i0033-7587-175-6-746-b23","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/nbt891","volume":"21","author":"Wild M. A.","year":"2003","journal-title":"Nat Biotechnol"},{"key":"i0033-7587-175-6-746-b25","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)00430-S"},{"key":"i0033-7587-175-6-746-b26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/stem.5530150713","volume":"15","author":"Neta R.","year":"1997","journal-title":"Stem Cells"},{"key":"i0033-7587-175-6-746-b27","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2007.04.017"},{"key":"i0033-7587-175-6-746-b28","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-140-12-200406150-00015"},{"key":"i0033-7587-175-6-746-b29","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1182\/blood-2008-04-150078","volume":"113","author":"Bussel J. B.","year":"2009","journal-title":"Blood"},{"key":"i0033-7587-175-6-746-b30","first-page":"91","volume":"12","author":"Kaushansky K.","year":"1994","journal-title":"Stem Cells"},{"key":"i0033-7587-175-6-746-b31","doi-asserted-by":"publisher","DOI":"10.1139\/y02-090"},{"key":"i0033-7587-175-6-746-b32","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(98)00477-5"},{"key":"i0033-7587-175-6-746-b33","doi-asserted-by":"publisher","DOI":"10.1081\/IPH-51289"},{"key":"i0033-7587-175-6-746-b34","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1964"},{"key":"i0033-7587-175-6-746-b35","first-page":"223","volume":"43","author":"Herodin F.","year":"2005","journal-title":"Folia Histochem Cytobiol"},{"key":"i0033-7587-175-6-746-b36","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1289\/ehp.97105s61473","volume":"105","author":"Weiss J. F.","year":"1997","journal-title":"Environ Health Perspect"},{"key":"i0033-7587-175-6-746-b37","doi-asserted-by":"publisher","DOI":"10.1080\/09553000902985128"},{"key":"i0033-7587-175-6-746-b38","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1532\/IJH97.05100","volume":"82","author":"Arai F.","year":"2005","journal-title":"Int J Hematol"},{"key":"i0033-7587-175-6-746-b39","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1634"},{"key":"i0033-7587-175-6-746-b40","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/milmed\/167.suppl_1.68","volume":"167","author":"MacVittie T. J.","year":"2002","journal-title":"Mil Med"},{"key":"i0033-7587-175-6-746-b41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0273-1177(92)90113-C","volume":"12","author":"Patchen M. L.","year":"1992","journal-title":"Adv Space Res"},{"key":"i0033-7587-175-6-746-b42","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1182\/blood.V76.3.445.445","volume":"76","author":"Tanikawa S.","year":"1990","journal-title":"Blood"},{"key":"i0033-7587-175-6-746-b43","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1667\/0033-7587(2002)157[0642:AORHIA]2.0.CO;2","volume":"157","author":"Van der Meeren A.","year":"2002","journal-title":"Radiat Res"},{"key":"i0033-7587-175-6-746-b44","doi-asserted-by":"publisher","DOI":"10.1016\/S0192-0561(99)00059-4"},{"key":"i0033-7587-175-6-746-b45","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1182\/blood.V56.1.42.42","volume":"56","author":"Seed T. M.","year":"1980","journal-title":"Blood"},{"key":"i0033-7587-175-6-746-b47","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1182\/blood.V92.1.4.413k38_4_10","volume":"92","author":"Solar G. P.","year":"1998","journal-title":"Blood"},{"key":"i0033-7587-175-6-746-b48","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood.V88.5.1619.1619","volume":"88","author":"Young J. C.","year":"1996","journal-title":"Blood"},{"key":"i0033-7587-175-6-746-b49","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0925-5710(97)00066-2","volume":"66","author":"Kobayashi M.","year":"1997","journal-title":"Int J Hematol"}],"container-title":["Radiation Research"],"original-title":[],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T03:18:19Z","timestamp":1592450299000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-175\/issue-6\/RR2462.1\/A-TPO-Receptor-Agonist-ALXN4100TPO-Mitigates-Radiation-Induced-Lethality-and\/10.1667\/RR2462.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,8]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2011,6,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rr2462.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4,8]]}}}