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M Boerma, et al.  \"Int J Radiat Oncol Biol Phys.\"  76, \"Radiation-related heart disease: current knowledge and future prospects\" 656 (2010;)","DOI":"10.1016\/j.ijrobp.2009.09.064"},{"key":"4","doi-asserted-by":"crossref","unstructured":"MP Little, A Gola, I Tzoulaki,  \"PLoS Comput Biol.\"  5, \"A model of cardiovascular disease giving a plausible mechanism for the effect of fractionated low-dose ionizing radiation exposure\" (2009;)","DOI":"10.1371\/journal.pcbi.1000539"},{"key":"5","doi-asserted-by":"crossref","unstructured":"SL McChesney, EL Gillette, BE Powers,  \"Radiat Res.\"  113, \"Radiation-induced cardiomyopathy in the dog\" 120 (1988;)","DOI":"10.2307\/3577185"},{"key":"6","doi-asserted-by":"crossref","unstructured":"BE Powers, HD Thames, EL Gillette,  \"Int J Radiat Oncol Biol Phys.\"  45, \"Long-term adverse effects of radiation inhibition of restenosis: radiation injury to the aorta and branch arteries in a canine model\" 753 (1999;)","DOI":"10.1016\/S0360-3016(99)00219-9"},{"key":"7","unstructured":"S Quarmby, RD Hunter, S Kumar,  \"Anticancer Res.\"  20, \"Irradiation induced expression of CD31, ICAM-1 and VCAM-1 in human microvascular endothelial cells\" 3375 (2000;)"},{"key":"8","doi-asserted-by":"crossref","unstructured":"S Quarmby, P Kumar, J Wang, et al.  \"Arterioscler Thromb Vasc Biol.\"  19, \"Irradiation induces upregulation of CD31 in human endothelial cells\" 588 (1999;)","DOI":"10.1161\/01.ATV.19.3.588"},{"key":"9","doi-asserted-by":"crossref","unstructured":"JB Allen, RH Sagerman, MJ Stuart,  \"Lancet.\"  2, \"Irradiation decreases vascular prostacyclin formation with no concomitant effect on platelet thromboxane production\" 1193 (1981;)","DOI":"10.1016\/S0140-6736(81)91437-9"},{"key":"10","doi-asserted-by":"crossref","unstructured":"JC Menendez, D Casanova, JA Amado, et al.  \"Int J Radiat Oncol Biol Phys.\"  41, \"Effects of radiation on endothelial function\" 905 (1998;)","DOI":"10.1016\/S0360-3016(98)00112-6"},{"key":"11","doi-asserted-by":"crossref","unstructured":"F Qi, T Sugihara, Y Hattori, et al.  \"Br J Pharmacol.\"  123, \"and morphological damage of endothelium in rabbit ear artery following irradiation with cobalt60\" 653 (1998;)","DOI":"10.1038\/sj.bjp.0701654"},{"key":"12","doi-asserted-by":"crossref","unstructured":"A Soloviev, I Prudnikov, V Tsyvkin, et al.  \"J Physiol Sci.\"  60, \"Electrophysiological and contractile evidence of the ability of human mesenchymal stromal cells to correct vascular malfunction in rats after ionizing irradiation\" 161 (2010;)","DOI":"10.1007\/s12576-009-0080-4"},{"key":"13","doi-asserted-by":"crossref","unstructured":"RF Furchgott  and PM Vanhoutte  \"FASEB J.\"  3, \"Endothelium-derived relaxing and contracting factors\" 2007 (1989;)","DOI":"10.1096\/fasebj.3.9.2545495"},{"key":"14","doi-asserted-by":"crossref","unstructured":"MW Aarnoudse, HB Lamberts, F Dijk, et al.  \"Virchows Arch B Cell Pathol 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(1992;)","DOI":"10.1007\/BF00299396"},{"key":"19","doi-asserted-by":"crossref","unstructured":"HE Kim, SS Dalal, E Young, et al.  \"J Clin Invest.\"  106, \"Disruption of the myocardial extracellular matrix leads to cardiac dysfunction\" 857 (2000;)","DOI":"10.1172\/JCI8040"},{"key":"20","doi-asserted-by":"crossref","unstructured":"S Hoving, S Heeneman, MJ Gijbels, et al.  \"PLoS One.\"  5, \"NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice\" (2010;)","DOI":"10.1371\/journal.pone.0012874"},{"key":"21","doi-asserted-by":"crossref","unstructured":"S Hoving, S Heeneman, MJ Gijbels, et al.  \"Int J Radiat Oncol Biol Phys.\"  71, \"Single-dose and fractionated irradiation promote initiation and progression of atherosclerosis and induce an inflammatory plaque phenotype in ApoE(\u2013\/\u2013) mice\" 848 (2008;)","DOI":"10.1016\/j.ijrobp.2008.02.031"},{"key":"22","doi-asserted-by":"crossref","unstructured":"H Huff  and EM Sanders  \"N Engl J Med.\"  286, \"Coronary-artery occlusion after radiation\" 780 (1972;)","DOI":"10.1056\/NEJM197204062861414"},{"key":"23","doi-asserted-by":"crossref","unstructured":"P Kumar, AI Miller, PJ Polverini,  \"J Biol Chem.\"  279, \"p38 MAPK mediates gamma-irradiation-induced endothelial cell apoptosis, and vascular endothelial growth factor protects endothelial cells through the phosphoinositide 3-kinase-Akt-Bcl-2 pathway\" 43352 (2004;)","DOI":"10.1074\/jbc.M405777200"},{"key":"24","doi-asserted-by":"crossref","unstructured":"M Natarajan, S Mohan, R Konopinski, et al.  \"Br J Radiol.\"  81, \"Induced telomerase activity in primary aortic endothelial cells by low-LET gamma-radiation is mediated through NF-kappaB activation\" 711 (2008;)","DOI":"10.1259\/bjr\/57867919"},{"key":"25","doi-asserted-by":"crossref","unstructured":"M Scharpfenecker, JJ Kruse, 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An electron microscopic study of myocardial microvasculature\" 125 (1974;)"},{"key":"54","doi-asserted-by":"crossref","unstructured":"M Boerma, C Zurcher, I Esveldt, et al.  \"Oncol Rep.\"  12, \"Histopathology of ventricles, coronary arteries and mast cell accumulation in transverse and longitudinal sections of the rat heart after irradiation\" 213 (2004;)","DOI":"10.3892\/or.12.2.213"},{"key":"55","doi-asserted-by":"crossref","unstructured":"GS Dimitrievich, SL Hausladen, FT Kuchnir, et al.  \"Radiat Res.\"  69, \"Radiation damage and subendothelial repair to rabbit ear chamber microvasculature. 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