{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:04:09Z","timestamp":1789643049275,"version":"4.0.0"},"reference-count":58,"publisher":"Radiation Research Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1667\/rr3245","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T18:04:13Z","timestamp":1153159453000},"page":"339-349","source":"Crossref","is-referenced-by-count":44,"title":["Influence of Dose Rate on the Induction of Simple and Complex Chromosome Exchanges by Gamma Rays"],"prefix":"10.1667","volume":"162","author":[{"given":"Bradford D.","family":"Loucas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Eberle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Bailey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael N.","family":"Cornforth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"i0033-7587-162-4-339-b1","doi-asserted-by":"publisher","DOI":"10.2307\/3578642"},{"key":"i0033-7587-162-4-339-b2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1161(94)90008-6"},{"key":"i0033-7587-162-4-339-b3","doi-asserted-by":"publisher","DOI":"10.1080\/095530096145724"},{"key":"i0033-7587-162-4-339-b4","doi-asserted-by":"publisher","DOI":"10.1080\/09553009514550051"},{"key":"i0033-7587-162-4-339-b5","doi-asserted-by":"crossref","unstructured":"Loucas, B. D. and M. N. Cornforth. Complex chromosome exchanges induced by gamma rays in human lymphocytes: An mFISH study. Radiat. Res 155:660\u2013671.2001.","DOI":"10.1667\/0033-7587(2001)155[0660:CCEIBG]2.0.CO;2"},{"key":"i0033-7587-162-4-339-b6","doi-asserted-by":"publisher","DOI":"10.1038\/ng0496-368"},{"key":"i0033-7587-162-4-339-b8","doi-asserted-by":"publisher","DOI":"10.1080\/095530096145724"},{"key":"i0033-7587-162-4-339-b9","doi-asserted-by":"crossref","unstructured":"Chadwick, K. H. and H. P. Leenhouts. Radiation induced chromosome aberrations: Some biophysical considerations. Mutat. Res 404:113\u2013117.1998.","DOI":"10.1016\/S0027-5107(98)00102-X"},{"key":"i0033-7587-162-4-339-b10","doi-asserted-by":"crossref","unstructured":"Griffin, C. S., M. A. Hill, D. G. Papworth, K. M. Townsend, J. R. Savage, and D. T. Goodhead. Effectiveness of 0.28 keV carbon K ultrasoft X-rays at producing simple and complex chromosome exchanges in human fibroblasts\n                      in vitro\n                      detected using FISH. Int. J. Radiat. Biol 73:591\u2013598.1998.","DOI":"10.1080\/095530098141834"},{"key":"i0033-7587-162-4-339-b11","doi-asserted-by":"publisher","DOI":"10.2307\/3575868"},{"key":"i0033-7587-162-4-339-b12","doi-asserted-by":"crossref","unstructured":"Cornforth, M. N., S. M. Bailey, and E. H. Goodwin. Dose responses for chromosome aberrations produced in noncycling primary human fibroblasts by alpha particles, and by gamma rays delivered at sublimiting low dose rates. Radiat. Res 158:43\u201353.2002.","DOI":"10.1667\/0033-7587(2002)158[0043:DRFCAP]2.0.CO;2"},{"key":"i0033-7587-162-4-339-b13","doi-asserted-by":"publisher","DOI":"10.2307\/3576926"},{"key":"i0033-7587-162-4-339-b14","doi-asserted-by":"crossref","unstructured":"Cornforth, M. N. Analyzing radiation-induced complex chromosome rearrangements by combinatorial painting. Radiat. Res 155:643\u2013659.2001.","DOI":"10.1667\/0033-7587(2001)155[0643:ARICCR]2.0.CO;2"},{"key":"i0033-7587-162-4-339-b15","unstructured":"Savage, J. R K. Reply to letter from Chadwick and Leenhouts: On the dose\u2013effect relationship of true simple chromosomal rearrangements. Int. J. Radiat. Biol 76:1428\u20131429. 2000. [letter]."},{"key":"i0033-7587-162-4-339-b16","doi-asserted-by":"crossref","unstructured":"Savage, J. R. and D. G. Papworth. Frequency and distribution studies of asymmetrical versus symmetrical chromosome aberrations. Mutat. Res 95:7\u201318.1982.","DOI":"10.1016\/0027-5107(82)90062-8"},{"key":"i0033-7587-162-4-339-b17","doi-asserted-by":"crossref","unstructured":"Nakano, M., E. Nakashima, D. J. Pawel, Y. Kodama, and A. Awa. Frequency of reciprocal translocations and dicentrics induced in human blood lymphocytes by X-irradiation as determined by fluorescence\n                      in situ\n                      hybridization. Int. J. Radiat. Biol 64:565\u2013569.1993.","DOI":"10.1080\/09553009314551781"},{"key":"i0033-7587-162-4-339-b18","doi-asserted-by":"crossref","unstructured":"Straume, T. and J. N. Lucas. A comparison of the yields of translocations and dicentrics measured using fluorescence\n                      in situ\n                      hybridization. Int. J. Radiat. Biol 64:185\u2013187.1993.","DOI":"10.1080\/09553009314551281"},{"key":"i0033-7587-162-4-339-b19","doi-asserted-by":"publisher","DOI":"10.2307\/3578788"},{"key":"i0033-7587-162-4-339-b20","doi-asserted-by":"publisher","DOI":"10.1080\/09553009514550351"},{"key":"i0033-7587-162-4-339-b21","doi-asserted-by":"crossref","unstructured":"Finnon, P., D. C. Lloyd, and A. A. Edwards. Fluorescence\n                      in situ\n                      hybridization detection of chromosomal aberrations in human lymphocytes: applicability to biological dosimetry. Int. J. Radiat. Biol 68:429\u2013435.1995.","DOI":"10.1080\/09553009514551391"},{"key":"i0033-7587-162-4-339-b22","doi-asserted-by":"publisher","DOI":"10.1080\/09553009514550031"},{"key":"i0033-7587-162-4-339-b23","doi-asserted-by":"crossref","unstructured":"Lucas, J. N., A. M. Chen, and R. K. Sachs. Theoretical predictions on the equality of radiation-produced dicentrics and translocations detected by chromosome painting. Int. J. Radiat. Biol 69:145\u2013153.1996.","DOI":"10.1080\/095530096145977"},{"key":"i0033-7587-162-4-339-b24","doi-asserted-by":"crossref","unstructured":"Finnon, P., J. E. Moquet, A. A. Edwards, and D. C. Lloyd. The\n                      60\n                      Co gamma ray dose-response for chromosomal aberrations analysed by FISH; applicability to biological dosimetry. Int. J. Radiat. Biol 75:1215\u20131222.1999.","DOI":"10.1080\/095530099139368"},{"key":"i0033-7587-162-4-339-b25","doi-asserted-by":"crossref","unstructured":"Hoffmann, G. R., A. M. Sayer, E. J. Joiner, A. F. McFee, and L. G. Littlefield. Analysis by FISH of the spectrum of chromosome aberrations induced by X-rays in G\n                      0\n                      lymphocytes and their fate through mitotic divisions in culture. Environ. Mol. Mutagen 33:94\u2013110.1999.","DOI":"10.1002\/(SICI)1098-2280(1999)33:2<94::AID-EM2>3.0.CO;2-E"},{"key":"i0033-7587-162-4-339-b26","doi-asserted-by":"crossref","unstructured":"Lucas, J. N., T. Tenjin, T. Straume, D. Pinkel, D. Moore 2nd, M. Litt, and J. W. Gray. Rapid human chromosome aberration analysis using fluorescence\n                      in situ\n                      hybridization. Int. J. Radiat. Biol 56:35\u201344.1989.","DOI":"10.1080\/09553008914551161"},{"key":"i0033-7587-162-4-339-b27","doi-asserted-by":"crossref","unstructured":"Cremer, T., S. Popp, P. Emmerich, P. Lichter, and C. Cremer. Rapid metaphase and interphase detection of radiation-induced chromosome aberrations in human lymphocytes by chromosomal suppression\n                      in situ\n                      hybridization. Cytometry 11:110\u2013118.1990.","DOI":"10.1002\/cyto.990110113"},{"key":"i0033-7587-162-4-339-b28","doi-asserted-by":"publisher","DOI":"10.1080\/09553009214550821"},{"key":"i0033-7587-162-4-339-b29","doi-asserted-by":"publisher","DOI":"10.1080\/09553009214552621"},{"key":"i0033-7587-162-4-339-b30","doi-asserted-by":"publisher","DOI":"10.1080\/09553009314551271"},{"key":"i0033-7587-162-4-339-b31","doi-asserted-by":"publisher","DOI":"10.1080\/09553009314551081"},{"key":"i0033-7587-162-4-339-b32","doi-asserted-by":"publisher","DOI":"10.1080\/09553009414550801"},{"key":"i0033-7587-162-4-339-b33","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(96)00144-3"},{"key":"i0033-7587-162-4-339-b34","doi-asserted-by":"publisher","DOI":"10.1080\/095530099140582"},{"key":"i0033-7587-162-4-339-b35","doi-asserted-by":"crossref","unstructured":"Crossen, P. E. and W. F. Morgan. Analysis of human lymphocyte cell cycle time in culture measured by sister chromatid differential staining. Exp. Cell Res 104:453\u2013457.1977.","DOI":"10.1016\/0014-4827(77)90116-1"},{"key":"i0033-7587-162-4-339-b36","doi-asserted-by":"publisher","DOI":"10.2307\/3576927"},{"key":"i0033-7587-162-4-339-b37","doi-asserted-by":"publisher","DOI":"10.2307\/3579715"},{"key":"i0033-7587-162-4-339-b38","doi-asserted-by":"crossref","unstructured":"Sachs, R. K., A. M. Chen, P. J. Simpson, L. R. Hlatky, P. Hahnfeldt, and J. R. Savage. Clustering of radiation-produced breaks along chromosomes: Modelling the effects on chromosome aberrations. Int. J. Radiat. Biol 75:657\u2013672.1999.","DOI":"10.1080\/095530099139999"},{"key":"i0033-7587-162-4-339-b39","doi-asserted-by":"publisher","DOI":"10.1080\/095530099140753"},{"key":"i0033-7587-162-4-339-b40","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088845"},{"key":"i0033-7587-162-4-339-b41","doi-asserted-by":"crossref","unstructured":"Johannes, C., I. Chudoba, and G. Obe. Analysis of X-ray-induced aberrations in human chromosome 5 using high-resolution multicolour banding FISH (mBAND). Chromosome Res 7:625\u2013633.1999.","DOI":"10.1023\/A:1009284018942"},{"key":"i0033-7587-162-4-339-b42","doi-asserted-by":"publisher","DOI":"10.1080\/09553009514550491"},{"key":"i0033-7587-162-4-339-b43","doi-asserted-by":"publisher","DOI":"10.1080\/095530000138989"},{"key":"i0033-7587-162-4-339-b44","doi-asserted-by":"crossref","unstructured":"Grigorova, M., R. Brand, Y. Xiao, and A. T. Natarajan. Frequencies and types of exchange aberrations induced by X-rays and neutrons in Chinese hamster splenocytes detected by FISH using chromosome-specific DNA libraries. Int. J. Radiat. Biol 74:297\u2013314.1998.","DOI":"10.1080\/095530098141447"},{"key":"i0033-7587-162-4-339-b45","doi-asserted-by":"crossref","unstructured":"Vazquez, M., K. M. Greulich-Bode, J. Arsuaga, M. N. Cornforth, M. Bruckner, R. K. Sachs, L. Hlatky, M. Molls, and P. Hahnfeldt. Computer analysis of mFISH chromosome aberration data uncovers an excess of very complicated metaphases. Int. J. Radiat. Biol 78:1103\u20131115.2002.","DOI":"10.1080\/09553000210166354"},{"key":"i0033-7587-162-4-339-b46","doi-asserted-by":"publisher","DOI":"10.2307\/3576633"},{"key":"i0033-7587-162-4-339-b47","doi-asserted-by":"publisher","DOI":"10.1080\/09553000050176225"},{"key":"i0033-7587-162-4-339-b48","doi-asserted-by":"publisher","DOI":"10.1080\/09553009314551901"},{"key":"i0033-7587-162-4-339-b49","unstructured":"Rothkamm, K., M. Kuhne, P. A. Jeggo, and M. Lobrich. Radiation-induced genomic rearrangements formed by nonhomologous end-joining of DNA double-strand breaks. Cancer Res 61:3886\u20133893.2001."},{"key":"i0033-7587-162-4-339-b50","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/15.4.289"},{"key":"i0033-7587-162-4-339-b51","doi-asserted-by":"publisher","DOI":"10.1080\/095530000138790"},{"key":"i0033-7587-162-4-339-b52","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00115-4"},{"key":"i0033-7587-162-4-339-b53","doi-asserted-by":"crossref","unstructured":"Essers, J., H. van Steeg, J. de Wit, S. M. Swagemakers, M. Vermeij, J. H. Hoeijmakers, and R. Kanaar. Homologous and non-homologous recombination differentially affect DNA damage repair in mice. EMBO J 19:1703\u20131710.2000.","DOI":"10.1093\/emboj\/19.7.1703"},{"key":"i0033-7587-162-4-339-b54","unstructured":"Pluth, J. M., L. M. Fried, and C. U. Kirchgessner. Severe combined immunodeficient cells expressing mutant hRAD54 exhibit a marked DNA double-strand break repair and error-prone chromosome repair defect. Cancer Res 61:2649\u20132655.2001."},{"key":"i0033-7587-162-4-339-b55","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204350"},{"key":"i0033-7587-162-4-339-b56","doi-asserted-by":"crossref","unstructured":"Lin, Y., T. Lukacsovich, and A. S. Waldman. Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomes. Mol. Cell. Biol 19:8353\u20138360.1999.","DOI":"10.1128\/MCB.19.12.8353"},{"key":"i0033-7587-162-4-339-b57","doi-asserted-by":"crossref","unstructured":"van den Bosch, M., P. H. Lohman, and A. Pastink. DNA double-strand break repair by homologous recombination. Biol. Chem 383:873\u2013892.2002.","DOI":"10.1515\/BC.2002.095"},{"key":"i0033-7587-162-4-339-b58","doi-asserted-by":"crossref","unstructured":"Richardson, C. and M. Jasin. Frequent chromosomal translocations induced by DNA double-strand breaks. Nature 405:697\u2013700.2000.","DOI":"10.1038\/35015097"},{"key":"i0033-7587-162-4-339-b59","doi-asserted-by":"crossref","unstructured":"Savage, J. R. The transmission of FISH-painted patterns derived from complex chromosome exchanges. Mutat. Res 347:87\u201395.1995.","DOI":"10.1016\/0165-7992(95)90075-6"}],"container-title":["Radiation Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T22:51:00Z","timestamp":1555714260000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.bioone.org\/doi\/10.1667\/RR3245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":58,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1667\/RR3245"],"URL":"https:\/\/doi.org\/10.1667\/rr3245","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}