{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:51:21Z","timestamp":1791219081854,"version":"4.1.0"},"reference-count":52,"publisher":"Radiation Research Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1667\/rr3280","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T21:34:46Z","timestamp":1153172086000},"page":"53-62","source":"Crossref","is-referenced-by-count":88,"title":["Induction of Accelerated Senescence by \u03b3 Radiation in Human Solid Tumor-Derived Cell Lines Expressing Wild-Type TP53"],"prefix":"10.1667","volume":"163","author":[{"given":"Razmik","family":"Mirzayans","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marybeth","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1243","reference":[{"key":"i0033-7587-163-1-53-b1","doi-asserted-by":"crossref","unstructured":"Sionov, R. V. and Y. Haupt. The cellular response to p53: The decision between life and death. Oncogene 18:6145\u20136157.1999.","DOI":"10.1038\/sj.onc.1203130"},{"key":"i0033-7587-163-1-53-b2","doi-asserted-by":"crossref","unstructured":"Ljungman, M. Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress. Neoplasia 2:208\u2013225.2000.","DOI":"10.1038\/sj.neo.7900073"},{"key":"i0033-7587-163-1-53-b3","doi-asserted-by":"crossref","unstructured":"Rotman, G. and Y. Shiloh. ATM: A mediator of multiple responses to genotoxic stress. Oncogene 18:6135\u20136144.1999.","DOI":"10.1038\/sj.onc.1203124"},{"key":"i0033-7587-163-1-53-b4","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/17.4.691"},{"key":"i0033-7587-163-1-53-b5","doi-asserted-by":"crossref","unstructured":"Brown, K. D., T. A. Lataxes, S. Shangary, J. L. Mannino, J. F. Giardina, J. Chen, and R. Baskaran. Ionizing radiation exposure results in up-regulation of Ku70 via a p53\/ataxia-telangiectasia-mutated protein-dependent mechanism. J. Biol. Chem 275:6651\u20136656.2000.","DOI":"10.1074\/jbc.275.9.6651"},{"key":"i0033-7587-163-1-53-b6","unstructured":"Offer, H., I. Zurer, G. Banfalvi, M. Reha'k, A. Falcovitz, M. Milyavsky, N. Goldfinger, and V. Rotter. p53 modulates base excision repair activity in a cell cycle-specific manner after genotoxic stress. Cancer Res 61:88\u201396.2001."},{"key":"i0033-7587-163-1-53-b7","doi-asserted-by":"crossref","unstructured":"Smith, M. L. and Y. R. Seo. p53 regulation of DNA excision repair pathways. Mutagenesis 17:149\u2013156.2002.","DOI":"10.1093\/mutage\/17.2.149"},{"key":"i0033-7587-163-1-53-b8","doi-asserted-by":"crossref","unstructured":"Barley, R. D C., L. Enns, M. C. Paterson, and R. Mirzayans. Aberrant p21WAF1-dependent growth arrest as the possible mechanism of abnormal resistance to ultraviolet light cytotoxicity in Li-Fraumeni syndrome fibroblast strains heterozygous for TP53 mutations. Oncogene 17:533\u2013543.1998.","DOI":"10.1038\/sj.onc.1202271"},{"key":"i0033-7587-163-1-53-b9","unstructured":"Chang, B. D., E. V. Broude, M. Dokmanovic, H. Zhu, A. Ruth, Y. Xuan, E. S. Kandel, E. Lausch, K. Christov, and I. B. Roninson. A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents. Cancer Res 59:3761\u20133767.1999."},{"key":"i0033-7587-163-1-53-b10","doi-asserted-by":"crossref","unstructured":"Chang, B. D., K. Watanabe, E. V. Broude, J. Fang, J. C. Poole, T. Kalinchenko, and I. B. Roninson. Effects of p21Waf1\/Cip1\/Sdi1on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases. Proc. Natl. Acad. Sci. USA 97:4291\u20134296.2000.","DOI":"10.1073\/pnas.97.8.4291"},{"key":"i0033-7587-163-1-53-b11","doi-asserted-by":"crossref","unstructured":"Chang, B. D., Y. Xuan, E. V. Broude, H. Zhu, B. Schott, J. Fang, and I. B. Roninson. Role of p53 and p21waf1\/cip1in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene 15:4808\u20134818.1999.","DOI":"10.1038\/sj.onc.1203078"},{"key":"i0033-7587-163-1-53-b12","doi-asserted-by":"crossref","unstructured":"Han, Z., W. Wei, S. Dunaway, J. W. Darnowski, P. Calabresi, J. Sedivy, E. A. Hendrickson, K. V. Balan, P. Pantazis, and J. H. Wyche. Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin. J. Biol. Chem 277:17154\u201317160.2002.","DOI":"10.1074\/jbc.M112401200"},{"key":"i0033-7587-163-1-53-b13","doi-asserted-by":"crossref","unstructured":"Sakamuro, D., P. Sabbatini, E. White, and G. C. Prendergast. The polyproline region of p53 is required to activate apoptosis but not growth arrest. Oncogene 18:887\u2013898.1997.","DOI":"10.1038\/sj.onc.1201263"},{"key":"i0033-7587-163-1-53-b14","doi-asserted-by":"crossref","unstructured":"Asada, M., T. Yamada, H. Ichijo, D. Delia, K. Miyazono, K. Fukumuro, and S. Mizutani. Apoptosis inhibitory activity of cytoplasmic p21(Cip1\/WAF1) in monocytic differentiation. EMBO J 18:1223\u20131234.1999.","DOI":"10.1093\/emboj\/18.5.1223"},{"key":"i0033-7587-163-1-53-b15","doi-asserted-by":"publisher","DOI":"10.1054\/drup.2001.0213"},{"key":"i0033-7587-163-1-53-b16","unstructured":"Roninson, I. B. Tumor cell senescence in cancer treatment. Cancer Res 63:2705\u20132715.2003."},{"key":"i0033-7587-163-1-53-b17","doi-asserted-by":"crossref","unstructured":"Rousseau, D., D. Cannella, J. Boulaire, P. Fitzgerald, A. Fotedar, and R. Fotedar. Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathway. Oncogene 18:4313\u20134325.1999.","DOI":"10.1038\/sj.onc.1202686"},{"key":"i0033-7587-163-1-53-b18","doi-asserted-by":"crossref","unstructured":"Chuang, L. S., H. I. Ian, T. W. Koh, H. H. Ng, G. Xu, and B. F. Li. Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1. Science 277:1996\u20132000.1997.","DOI":"10.1126\/science.277.5334.1996"},{"key":"i0033-7587-163-1-53-b19","doi-asserted-by":"crossref","unstructured":"Baylin, S. B. Tying it all together: Epigenetics, genetics, cell cycle, and cancer. Science 277:1948\u20131949.1997.","DOI":"10.1126\/science.277.5334.1948"},{"key":"i0033-7587-163-1-53-b20","doi-asserted-by":"crossref","unstructured":"Mirzayans, R., R. A. Aubin, W. Bosnich, W. A. Blattner, and M. C. Paterson. Abnormal pattern of post-\u03b3-ray DNA replication in radioresistant fibroblast strains from affected members of a cancer-prone family with Li-Fraumeni syndrome. Br. J. Cancer 71:1221\u20131230.1995.","DOI":"10.1038\/bjc.1995.237"},{"key":"i0033-7587-163-1-53-b21","unstructured":"O'Connor, P. M., J. Jackman, I. Bae, T. G. Myers, S. Fan, M. Mutoh, D. A. Scudiero, A. Monks, E. A. Sausville, and K. W. Kohn. Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents. Cancer Res 57:4285\u20134300.1997."},{"key":"i0033-7587-163-1-53-b22","unstructured":"Waldman, T., K. W. Kinzler, and B. Vogelstein. p21 is necessary for the p53-mediated G1arrest in human cancer cells. Cancer Res 55:5187\u20135190.1995."},{"key":"i0033-7587-163-1-53-b23","doi-asserted-by":"crossref","unstructured":"Kroumpouzos, G., J. Eberle, C. Garbe, and C. E. Orfanos. P53 mutation and c-fos overexpression are associated with detection of the antigen VLA-2 in human melanoma cell lines. Pigment. Cell Res 7:348\u2013353.1994.","DOI":"10.1111\/j.1600-0749.1994.tb00638.x"},{"key":"i0033-7587-163-1-53-b24","doi-asserted-by":"crossref","unstructured":"Dornan, D. and T. R. Hupp. Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300. EMBO Rep 2:139\u2013144.2001.","DOI":"10.1093\/embo-reports\/kve025"},{"key":"i0033-7587-163-1-53-b25","unstructured":"Gaitonde, S. V., W. Qi, R. R. Falsey, N. Sidell, and J. D. Martinez. Morphologic conversion of a neuroblastoma-derived cell line by E6-mediated p53 degradation. Cell Growth Differ 12:19\u201327.2001."},{"key":"i0033-7587-163-1-53-b26","doi-asserted-by":"publisher","DOI":"10.1080\/09553009214552301"},{"key":"i0033-7587-163-1-53-b27","doi-asserted-by":"crossref","unstructured":"Mirzayans, R., S. Pollock, A. Scott, C. Q. Gao, and D. Murray. Metabolic labeling of human cells with tritiated nucleosides results in activation of the ATM-dependent p53 signaling pathway and acceleration of DNA repair. Oncogene 22:5562\u20135571.2003.","DOI":"10.1038\/sj.onc.1206514"},{"key":"i0033-7587-163-1-53-b28","doi-asserted-by":"crossref","unstructured":"Bickar, D. and R. D. Reid. A high-affinity protein stain for western blots, tissue prints, and electrophoretic gels. Anal. Biochem 203:109\u2013115.1992.","DOI":"10.1016\/0003-2697(92)90049-D"},{"key":"i0033-7587-163-1-53-b29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.20.9363"},{"key":"i0033-7587-163-1-53-b30","doi-asserted-by":"publisher","DOI":"10.2307\/3579515"},{"key":"i0033-7587-163-1-53-b31","unstructured":"Gomez-Manzano, C., J. Fueyo, A. P. Kyritsis, P. A. Steck, J. A. Roth, T. J. McDonnell, K. D. Steck, V. A. Levin, and W. K. Yung. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res 56:694\u2013699.1996."},{"key":"i0033-7587-163-1-53-b32","doi-asserted-by":"crossref","unstructured":"Chin, L. S., C. C. Park, K. M. Zitnay, M. Sinha, A. J. DiPatri Jr., P. Perillan, and J. M. Simard. 4-Aminopyridine causes apoptosis and blocks an outward rectifier K+ channel in malignant astrocytoma cell lines. J. Neurosci. Res 48:122\u2013127.1997.","DOI":"10.1002\/(SICI)1097-4547(19970415)48:2<122::AID-JNR4>3.3.CO;2-1"},{"key":"i0033-7587-163-1-53-b33","doi-asserted-by":"crossref","unstructured":"Kataoka, Y., J. S. Murley, R. Patel, and D. J. Grdina. Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines. Int. J. Radiat. Biol 76:633\u2013639.2000.","DOI":"10.1080\/095530000138295"},{"key":"i0033-7587-163-1-53-b34","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3301327"},{"key":"i0033-7587-163-1-53-b35","doi-asserted-by":"crossref","unstructured":"Kim, I. A., Y. J. Yang, S. C. Yoon, I. B. Choi, C. S. Kay, H. C. Kwon, C. M. Kim, Y. A. Joe, J. K. Kang, and Y. K. Hong. Potential of adenoviral p53 gene therapy and irradiation for the treatment of malignant gliomas. Int. J. Oncol 19:1041\u20131047.2001.","DOI":"10.3892\/ijo.19.5.1041"},{"key":"i0033-7587-163-1-53-b36","doi-asserted-by":"crossref","unstructured":"Badie, B., C. S. Goh, J. Klaver, H. Herweijer, and D. A. Boothman. Combined radiation and p53 gene therapy of malignant glioma cells. Cancer Gene Ther 6:155\u2013162.1999.","DOI":"10.1038\/sj.cgt.7700009"},{"key":"i0033-7587-163-1-53-b37","doi-asserted-by":"crossref","unstructured":"Khalid, M. H., S. Shibata, and T. Hiura. Effects of clotrimazole on the growth, morphological characteristics, and cisplatin sensitivity of human glioblastoma cellsin vitro. J. Neurosurg 90:918\u2013927.1999.","DOI":"10.3171\/jns.1999.90.5.0918"},{"key":"i0033-7587-163-1-53-b38","doi-asserted-by":"crossref","unstructured":"Okaichi, K., K. Suzuki, N. Morita, M. Ikeda, H. Takahashi, N. Matsuda, M. Watanabe, and Y. Okumura. Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway. Oncol. Rep 9:859\u2013862.2002.","DOI":"10.3892\/or.9.4.859"},{"key":"i0033-7587-163-1-53-b39","doi-asserted-by":"publisher","DOI":"10.1002\/mc.20005"},{"key":"i0033-7587-163-1-53-b40","doi-asserted-by":"crossref","unstructured":"Wolff, A., A. Technau, C. Ihling, K. Technau-Ihling, R. Erber, F. X. Bosch, and G. Brandner. Evidence that wild-type p53 in neuroblastoma cells is in a conformation refractory to integration into the transcriptional complex. Oncogene 20:1307\u20131317.2001.","DOI":"10.1038\/sj.onc.1204251"},{"key":"i0033-7587-163-1-53-b41","unstructured":"Myohanen, S. K., S. B. Baylin, and J. G. Herman. Hypermethylation can selectively silence individual p16ink4Aalleles in neoplasia. Cancer Res 58:591\u2013593.1998."},{"key":"i0033-7587-163-1-53-b42","unstructured":"Wouters, B. G., A. J. Giaccia, N. C. Denko, and J. M. Brown. Loss of p21Waf1\/Cip1sensitizes tumors to radiation by an apoptosis-independent mechanism. Cancer Res 57:4703\u20134706.1997."},{"key":"i0033-7587-163-1-53-b43","doi-asserted-by":"crossref","unstructured":"Larsson, C. and C. E. Ng. p21+\/+(CDKN1A+\/+) and p21\u2212\/\u2212(CDKN1A\u2212\/\u2212) human colorectal carcinoma cells display equivalent amounts of thermal radiosensitization. Radiat. Res 160:205\u2013209.2003.","DOI":"10.1667\/3031"},{"key":"i0033-7587-163-1-53-b44","unstructured":"Tian, H., E. K. Wittmack, and T. J. Jorgensen. p21WAF1\/CIP1antisense therapy radiosensitizes human colon cancer by converting growth arrest to apoptosis. Cancer Res 60:679\u2013684.2000."},{"key":"i0033-7587-163-1-53-b45","doi-asserted-by":"crossref","unstructured":"Zong, W. X., D. Ditsworth, D. E. Bauer, Z. Q. Wang, and C. B. Thompson. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18:1272\u20131282.2004.","DOI":"10.1101\/gad.1199904"},{"key":"i0033-7587-163-1-53-b46","doi-asserted-by":"crossref","unstructured":"Castedo, M., J. L. Perfettini, T. Roumier, K. Andreau, R. Medema, and G. Kroemer. Cell death by mitotic catastrophe: A molecular definition. Oncogene 23:2825\u20132837.2004.","DOI":"10.1038\/sj.onc.1207528"},{"key":"i0033-7587-163-1-53-b47","doi-asserted-by":"crossref","unstructured":"Sundaram, M., D. L. Guernsey, M. M. Rajaraman, and R. Rajaraman. Neosis: A novel type of cell division in cancer. Cancer Biol. Ther 3:207\u2013218.2004.","DOI":"10.4161\/cbt.3.2.663"},{"key":"i0033-7587-163-1-53-b48","unstructured":"Brown, J. M. and B. G. Wouters. Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 59:1391\u20131399.1999."},{"key":"i0033-7587-163-1-53-b49","doi-asserted-by":"crossref","unstructured":"Sionov, R. V. and Y. Haupt. The cellular response to p53: the decision between life and death. Oncogene 18:6145\u20136157.1999.","DOI":"10.1038\/sj.onc.1203130"},{"key":"i0033-7587-163-1-53-b50","unstructured":"Fisher, D. E. The p53 tumor suppressor: Critical regulator of life and death in cancer. Apoptosis 6:7\u201315.2001."},{"key":"i0033-7587-163-1-53-b51","doi-asserted-by":"crossref","unstructured":"Pei, F. and W. S. El-Deiry. P53 and radiation responses. Oncogene 22:5774\u20135783.2003.","DOI":"10.1038\/sj.onc.1206677"},{"key":"i0033-7587-163-1-53-b52","doi-asserted-by":"crossref","unstructured":"Fotedar, R., M. Bendjennat, and A. Fotedar. Role of p21WAF1in the cellular response to UV. Cell Cycle 3:134\u2013137.2004.","DOI":"10.4161\/cc.3.2.658"}],"container-title":["Radiation Research"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T02:46:23Z","timestamp":1555728383000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.bioone.org\/doi\/10.1667\/RR3280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1667\/RR3280"],"URL":"https:\/\/doi.org\/10.1667\/rr3280","relation":{},"ISSN":["0033-7587","1938-5404"],"issn-type":[{"value":"0033-7587","type":"print"},{"value":"1938-5404","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}