{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T19:51:40Z","timestamp":1774122700435,"version":"3.50.1"},"reference-count":47,"publisher":"Radiation Research Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiation Research"],"published-print":{"date-parts":[[2017,2,16]]},"DOI":"10.1667\/rr4413.1","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T22:23:55Z","timestamp":1487283835000},"page":"298","source":"Crossref","is-referenced-by-count":45,"title":["AEOL 10150 Mitigates Radiation-Induced Lung Injury in the Nonhuman Primate: Morbidity and Mortality are Administration Schedule-Dependent"],"prefix":"10.1667","volume":"187","author":[{"given":"Thomas J.","family":"MacVittie","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann M.","family":"Farese","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kory","family":"Barrow","sequence":"additional","affiliation":[{"name":"SNBL USA Ltd., Everett, Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Bennett","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheryl","family":"Taylor-Howell","sequence":"additional","affiliation":[{"name":"Clinical Research Management, Frederick, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul","family":"Kazi","sequence":"additional","affiliation":[{"name":"VA Maryland Health Care System, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Prado","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, University of Maryland, School of Medicine, Baltimore, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Parker","sequence":"additional","affiliation":[{"name":"Charles River Laboratories, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William Jackson","family":"III","sequence":"additional","affiliation":[{"name":"Statistician, Rockville, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1243","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"SJ, van der Veen, G, Ghobadi, RA, de Boer, et al. \"Radiother Oncol.\" 114, \"ACE inhibition attenuates radiation-induced cardiopulmonary damage\" 96 (2015)","DOI":"10.1016\/j.radonc.2014.11.017"},{"key":"1","doi-asserted-by":"crossref","unstructured":"AE, Baranov, GD, Selidovkin, A, Butturini, et al. \"Blood.\" 83, \"Hematopoietic recovery after 10-Gy acute total body radiation\" 596 (1994)","DOI":"10.1182\/blood.V83.2.596.bloodjournal832596"},{"key":"1","doi-asserted-by":"crossref","unstructured":"H, Uozaki, M, Fukayama, K, Nakagawa, et al. \"Br J Radiol.\" 27, \"The pathology of multi-organ involvement: two autopsy cases from the Tokai-mura criticality accident\" 13 (2005)","DOI":"10.1259\/bjr\/70312032"},{"key":"1","doi-asserted-by":"crossref","unstructured":"S. Asano, \"Br J Radiol.\" , \"Multi-organ involvement: lessons from the experience of one victim of the Tokai-mura criticality accident\" (2005)","DOI":"10.1259\/bjr\/17540147"},{"key":"1","doi-asserted-by":"crossref","unstructured":"N, Dainiak, RN, Gent, Z, Carr, et al. \"Disaster Med Public Health Prep.\" 5, \"Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems\" 183 (2011)","DOI":"10.1001\/dmp.2011.73"},{"key":"1","doi-asserted-by":"crossref","unstructured":"AK, Guskova, N, Nadezhina, AV, Barabanova, et al. \"Treatment of radiation injuries.\" , \"Acute effects of radiation exposure following the Chernobyl acident, Immediate results of radiation sickness and outcome of treatment\" 195 (1990)","DOI":"10.1007\/978-1-4899-0864-3_20"},{"key":"1","doi-asserted-by":"crossref","unstructured":"N, Dainiak, RN, Gent, Z, Carr, et al. \"Disaster Med Public Health Prep.\" 5, \"First global consensus for evidence-based management of the hematopoietic syndrome resulting from exposure to ionizing radiation\" 202 (2011)","DOI":"10.1001\/dmp.2011.68"},{"key":"1","unstructured":"LM, Crawford, \"Federal Register.\" 67, \"Food and Drug Administration. New drug and biological drug products; evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. 21 CFR Pt. 314 and 601\" 37988 (2002)"},{"key":"1","unstructured":"et al. \"Center for Drug Evaluation and Research, Food and Drug Administration.\" , \"Product development under the animal rule: guidance for industry\" (2015)"},{"key":"1","doi-asserted-by":"crossref","unstructured":"M, Garofalo, A, Bennett, AM, Farese, et al. \"Health Phys.\" 106, \"The delayed pulmonary syndrome following acute high-dose irradiation: a rhesus macaque model\" 56 (2014)","DOI":"10.1097\/HP.0b013e3182a32b3f"},{"key":"1","doi-asserted-by":"crossref","unstructured":"MC, Garofalo, AA, Ward, AM, Farese, et al. \"Health Phys.\" 106, \"A pilot study in rhesus macaques to assess the treatment efficacy of a small molecular weight catalytic metalloporphyrin antioxidant (AEOL 10150) in mitigating radiation-induced lung damage\" 73 (2014)","DOI":"10.1097\/HP.0b013e3182a4d967"},{"key":"1","doi-asserted-by":"crossref","unstructured":"A, Novakova-Jiresova, P, van Luijk, H, van Goor, et al. \"Cancer Res.\" 65, \"Pulmonary radiation injury: identification of risk factors associated with regional hypersensitivity\" 3568 (2005)","DOI":"10.1158\/0008-5472.CAN-04-3466"},{"key":"1","doi-asserted-by":"crossref","unstructured":"G, Ghobadi, S, van der Veen, B, Bartelds, et al. \"Int J Radiat Oncol Biol Phys.\" 84, \"Physiological interaction of heart and lung in thoracic irradiation\" e639 (2012)","DOI":"10.1016\/j.ijrobp.2012.07.2362"},{"key":"1","doi-asserted-by":"crossref","unstructured":"P, van Luijk, A, Novakova-Jiresova, H, Faber, et al. \"Cancer Res.\" 65, \"Radiation damage to the heart enhances early radiation-induced lung function loss\" 6509 (2005)","DOI":"10.1158\/0008-5472.CAN-05-0786"},{"key":"1","doi-asserted-by":"crossref","unstructured":"P, van Luijk, H, Faber, H, Meertens, et al. \"Int J Radiat Oncol Biol Phys.\" 69, \"The impact of heart irradiation on dose-volume effects in the rat lung\" 552 (2007)","DOI":"10.1016\/j.ijrobp.2007.05.065"},{"key":"1","doi-asserted-by":"crossref","unstructured":"C, Prado, A, Kazi, AW, Bennet, et al. \"Health Phys.\" 109, \"Mean organ doses resulting from non-human primate whole thorax lung irradiation prescribed to mid-line tissue\" 367 (2015)","DOI":"10.1097\/HP.0000000000000336"},{"key":"1","doi-asserted-by":"crossref","unstructured":"EB, de Faria, K, Barrow, BT, Ruehle, et al. \"Health Phys.\" 109, \"The evolving MCART multimodal imaging core: Establishing a protocol for computed tomography and echocardiography in the rhesus macaque to perform longitudinal analysis of radiation-induced organ injury\" 479 (2015)","DOI":"10.1097\/HP.0000000000000344"},{"key":"1","doi-asserted-by":"crossref","unstructured":"M, Medhora, F, Gao, C, Glisch, et al. \"J Radiat Res.\" 56, \"Whole-thorax irradiation induces hypoxic respiratory failure, pleural effusions and cardiac remodeling\" 248 (2015)","DOI":"10.1093\/jrr\/rru095"},{"key":"1","doi-asserted-by":"crossref","unstructured":"Z, Vujaskovic, I, Batinic-Haberle, ZN, Rabbani, et al. \"Free Radic Biol Med.\" 33, \"A small molecular weight catalytic metalloporphryin antioxidant with superoxide dosmutase (SOD) mimetic properties protects lungs from radiation-induced injury\" 857 (2002)","DOI":"10.1016\/S0891-5849(02)00980-2"},{"key":"1","doi-asserted-by":"crossref","unstructured":"ZN, Rabbani, FK, Salahuddin, P, Yarmolenko, et al. \"Free Radic Res.\" 41, \"Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation\" 1273 (2007)","DOI":"10.1080\/10715760701689550"},{"key":"1","doi-asserted-by":"crossref","unstructured":"P, Flechsig, M, Dadrich, S, Bickelhaupt, et al. \"Clin Cancer Res.\" 18, \"LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGFb and BMP-associated proinflammatory and proangiogenic signals\" 3616 (2012)","DOI":"10.1158\/1078-0432.CCR-11-2855"},{"key":"1","doi-asserted-by":"crossref","unstructured":"Q, Wang, W, Usinger, B, Nichols, et al. \"Fibrogenesis Tissue Repair.\" 4, \"Cooperative interaction of CTGF and TGF-b in animal models of fibrotic disease\" 4 (2011)","DOI":"10.1186\/1755-1536-4-4"},{"key":"1","doi-asserted-by":"crossref","unstructured":"PE, Huber, S, Bickelhaupt, P, Peschke, et al. \"Am J Respir Crit Care Med.\" 181, \"Reversal of established fibrosis by treatment with the anti-CTGF monoclonal antibody FG-3019 in a murine model of radiation-induced pulmonary fibrosis\" A1054 (2010)","DOI":"10.1164\/ajrccm-conference.2010.181.1_MeetingAbstracts.A1054"},{"key":"1","doi-asserted-by":"crossref","unstructured":"KE, Lipson, C, Wong, Y, Teng, et al. \"Fibrogenesis Tissue Repair.\" 5, \"CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis\" S24 (2012)","DOI":"10.1186\/1755-1536-5-S1-S24"},{"key":"1","doi-asserted-by":"crossref","unstructured":"D, Alapati, M, Rong, S, Chen, et al. \"Am J Respir Cell Mol Biol.\" 45, \"Connective tissue growth factor antibody therapy attenuates hyperoxia-induced lung injury in neonatal rats\" 1169 (2011)","DOI":"10.1165\/rcmb.2011-0023OC"},{"key":"1","doi-asserted-by":"crossref","unstructured":"F, Gao, BL, Fish, A, Szabo, et al. \"Radiat Res.\" 178, \"Short-term treatment with a SOD\/catalase mimetic, EUK-207, mitigates pneumonitis and fibrosis after single-dose total-body or whole thoracic irradiation\" 468 (2012)","DOI":"10.1667\/RR2953.2"},{"key":"1","doi-asserted-by":"crossref","unstructured":"M, Epperly, J, Bray, S, Kraeger, et al. \"Gene Therapy.\" 5, \"Prevention of late effects of irradaiation lung damage by manganese superoxide dismutase gene therapy\" 196 (1998)","DOI":"10.1038\/sj.gt.3300580"},{"key":"1","doi-asserted-by":"crossref","unstructured":"A, Abdollahi, M, Li, G, Ping, et al. \"J Exp Med.\" 201, \"Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis\" 925 (2005)","DOI":"10.1084\/jem.20041393"},{"key":"1","doi-asserted-by":"crossref","unstructured":"N, Srour and B. Thebaud \"Stem Cells Transl Med.\" 4, \"Mesenchymal stromal cells in animal bleomycin pulmonary fibrosis models: A systematic review\" 1500 (2015)","DOI":"10.5966\/sctm.2015-0121"},{"key":"1","doi-asserted-by":"crossref","unstructured":"X, Fang, J, Abbott, L, Cheng, et al. \"J Immunol.\" 195, \"Human mesenchymal stem (stromal) cells promote the resolution of acute lung injury in part through lipoxin A4\" 875 (2015)","DOI":"10.4049\/jimmunol.1500244"},{"key":"1","doi-asserted-by":"crossref","unstructured":"PA. Riley, \"Int J Radiat Oncol Biol Phys.\" 65, \"Free radicals in biology: Oxidative stress and the effects of ionizing radiation\" 27 (1994)","DOI":"10.1080\/09553009414550041"},{"key":"1","doi-asserted-by":"crossref","unstructured":"D, Schaue, EL, Kachikwu, WH. McBride, \"Radiat Res.\" 178, \"Cytokines in radiobiological responses: a review\" 505 (2012)","DOI":"10.1667\/RR3031.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"ZN, Rabbani, I, Batinic-Haberle, MS, Anscher, et al. \"Int J Radiat Oncol Biol Phys.\" 67, \"Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury\" 573 (2007)","DOI":"10.1016\/j.ijrobp.2006.09.053"},{"key":"1","doi-asserted-by":"crossref","unstructured":"BG, Gauter-Fleckenstein, K, Fleckenstein, K, Owzar, et al. \"Free Radic Biol Med.\" 48, \"Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage\" 1034 (2010)","DOI":"10.1016\/j.freeradbiomed.2010.01.020"},{"key":"1","doi-asserted-by":"crossref","unstructured":"FN, Murigi, P, Mohindra, C, Hung, et al. \"Radiat Res.\" 184, \"Dose optimization study of AEOL 10150 as a mitigator of radiation-induced lung injury in CBA\/J mice\" 422 (2015)","DOI":"10.1667\/RR14110.1"},{"key":"1","doi-asserted-by":"crossref","unstructured":"TJ, MacVittie, A, Bennett, C, Booth, et al. \"Health Phys.\" 103, \"The prolonged gastrointestinal syndrome in rhesus macaques: the relationship between gastrointestinal, hematopoietic, and delayed multi-organ sequelae following acute, potentially lethal, partial-body irradiation\" 427 (2012)","DOI":"10.1097\/HP.0b013e318266eb4c"},{"key":"1","doi-asserted-by":"crossref","unstructured":"IL, Jackson, X, Zhang, C, Hadley, et al. \"Free Radic Biol Med.\" 53, \"Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung\" 337 (2012)","DOI":"10.1016\/j.freeradbiomed.2012.04.014"},{"key":"1","doi-asserted-by":"crossref","unstructured":"NJ. Gross, \"J Clin Invest.\" 66, \"Radiation pneumonitis in mice. Some effects of corticosteroids on mortality and pulmonary physiology\" 504 (1980)","DOI":"10.1172\/JCI109881"},{"key":"1","doi-asserted-by":"crossref","unstructured":"NJ, Gross and KR, Narine \"Radiat Res.\" 113, \"Wade R. Protective effect of corticosteroids on radiation pneumonitis in mice\" 112 (1988)","DOI":"10.2307\/3577184"},{"key":"1","doi-asserted-by":"crossref","unstructured":"TL, Phillips, MD, Wharam, LW. Margolis, \"Cancer.\" 35, \"Modification of radiation injury to normal tissues by chemotherapeutic agents\" 1678 (1975)","DOI":"10.1002\/1097-0142(197506)35:6<1678::AID-CNCR2820350629>3.0.CO;2-K"},{"key":"1","doi-asserted-by":"crossref","unstructured":"JP, Geraci, MS, Mariano, KL, Jackson, et al. \"Radiat Res.\" 129, \"Effects of dexamethasone on late radiation injury following partial-body and local organ exposures\" 61 (1992)","DOI":"10.2307\/3577904"},{"key":"1","doi-asserted-by":"crossref","unstructured":"J, Van Dyk, TJ, Keane, S, Kan, et al. \"Int J Radiat Oncol Biol Phys.\" 7, \"Radiation pneumonitis following large single dose irradiation: a re-evaluation based on absolute dose to lung\" 461 (1981)","DOI":"10.1016\/0360-3016(81)90131-0"},{"key":"1","doi-asserted-by":"crossref","unstructured":"CJH, Fryer, PJ, Fitzpatrick, WD, Rider, et al. \"Int J Radiat Oncol.\" 4, \"Radiation pneumonitis: experience following a large single dose of radiation\" 931 (1978)","DOI":"10.1016\/0360-3016(78)90002-0"},{"key":"1","doi-asserted-by":"crossref","unstructured":"FS, Prato, R, Kurdyak, EA, Saibil, et al. \"Cancer.\" 39, \"The incidence of radiation pneumonitis as a result of single fraction upper half body irradiation\" 71 (1977)","DOI":"10.1002\/1097-0142(197701)39:1<71::AID-CNCR2820390114>3.0.CO;2-F"},{"key":"1","unstructured":"et al. \"Vienna: International Atomic Energy Agency; 2002.\" , \"IAEA, 2002\" ()"},{"key":"1","doi-asserted-by":"crossref","unstructured":"TJ, MacVittie, AW, Bennett, AM, Farese, et al. \"Health Phys.\" 109, \"The effect of radiation dose and variation in Neupogen(R) initiation schedule on the mitigation of myelosuppression during the concomitant GI-ARS and H-ARS in a nonhuman primate model of high-dose exposure with marrow sparing\" 427 (2015)","DOI":"10.1097\/HP.0000000000000350"},{"key":"1","unstructured":"FJ. Berkely, \"Am Fam Physician.\" 82, \"Managing the adverse effects of radiation therapy\" 381 (2010)"}],"container-title":["Radiation Research"],"original-title":[],"link":[{"URL":"http:\/\/www.bioone.org\/doi\/full-xml\/10.1667\/RR4413.1","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T15:32:55Z","timestamp":1601652775000},"score":1,"resource":{"primary":{"URL":"https:\/\/bioone.org\/journals\/radiation-research\/volume-187\/issue-3\/RR4413.1\/AEOL-10150-Mitigates-Radiation-Induced-Lung-Injury-in-the-Nonhuman\/10.1667\/RR4413.1.full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,16]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,3,1]]}},"URL":"https:\/\/doi.org\/10.1667\/rr4413.1","relation":{},"ISSN":["0033-7587"],"issn-type":[{"value":"0033-7587","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2,16]]}}}