{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:20Z","timestamp":1784557100017,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["erc.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p>\n                    The impairment of apoptotic pathways represents an efficient mechanism to promote chemoresistance in cancer cells. We previously showed that in epithelial ovarian cancer (EOC) cells, long isoform of cellular FLICE-inhibitory protein (c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    ) accounts for apoptosis resistance in a context of functional p53 and resistance could be overcome by c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    downmodulation. Here, we studied the association between c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    and p53 expressions and their prognostic impact in EOC patients. Tumor tissue from 207 patients diagnosed with primary EOC was analyzed by immunohistochemistry (IHC) for c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    and p53 expressions, and multiple correspondence analysis (MCA) was used to evaluate the multivariable pattern of association among patients' clinical\u2013pathological characteristics and biological determinants. IHC revealed c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    expression and p53 nuclear accumulation inversely related (\n                    <jats:italic>P<\/jats:italic>\n                    =0.0001; odds ratio=0.29, confidence interval (CI)=0.15\u20130.055). MCA indicated that p53 accumulation was associated to clinical\u2013pathological variables, while c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    expression contributed to the overall association pattern independently from other's clinical characteristics and complementary to p53. Kaplan\u2013Meier curves showed a reduced survival time according to c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    expression in concert with p53 accumulation (median overall survival (OS): 35 months) compared with lack of expression of both markers (median OS: 110 months; log-rank test,\n                    <jats:italic>P<\/jats:italic>\n                    value=0.024). The multivariable Cox regression model, adjusted for known prognostic factors, identified c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    expression, but not p53 nuclear accumulation, as an independent prognostic factor for adverse outcome (hazard ratio=1.82, 95% CI=1.17\u20132.82;\n                    <jats:italic>P<\/jats:italic>\n                    =0.008). Altogether these data support the independent contribution of c-FLIP\n                    <jats:sub>L<\/jats:sub>\n                    in refining the prognostic information obtained from standard clinical\u2013pathological indicators, confirming its pivotal role in promoting cell survival.\n                  <\/jats:p>","DOI":"10.1677\/erc-08-0218","type":"journal-article","created":{"date-parts":[[2009,3,25]],"date-time":"2009-03-25T20:56:18Z","timestamp":1238014578000},"page":"443-453","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":16,"title":["c-FLIPL expression defines two ovarian cancer patient subsets and is a prognostic factor of adverse outcome"],"prefix":"10.1530","volume":"16","author":[{"given":"Marina","family":"Bagnoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Ambrogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Pilotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Ditto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mattia","family":"Barbareschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Galligioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elia","family":"Biganzoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Canevari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Mezzanzanica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-Related Cancer"],"original-title":[],"link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/16\/2\/443.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/erc.bioscientifica.com\/downloadpdf\/journals\/erc\/16\/2\/443.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:52:19Z","timestamp":1784555539000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/erc\/article\/16\/2\/443-453\/34540"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1677\/erc-08-0218","relation":{},"ISSN":["1351-0088","1479-6821"],"issn-type":[{"value":"1351-0088","type":"print"},{"value":"1479-6821","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}