{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:47:52Z","timestamp":1788338872307,"version":"build-2803163510"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Parathyroid hormone (PTH) and PTH-related protein\/peptide (PTHrP) bind to the same PTH\/PTHrP receptor and stimulate osteoblasts to secrete pro-inflammatory cytokines like interleukin (IL)-6. In patients with primary hyperparathyroidism, elevation of plasma levels of tumor necrosis factor (TNF)-alpha and IL-6 was also described. We, therefore, postulated that PTHrP secreted from cancer cells stimulates the secretion of cytokines and causes increases in their blood levels. Blood concentrations of several cytokines (TNF-alpha, IL-1beta, IL-5, IL-6, IL-8, IL-11 and IL-12) in cancer-bearing patients with or without elevation of blood PTHrP were measured by ELISA. The patients with high plasma PTHrP levels (n=29, intact PTHrP: 8.5 +\/- 1.4 pmol\/l, normal: &amp;lt;1.1) had higher serum type 1 collagen C-telopeptide (ICTP). Twenty of the patients were hypercalcemic. Plasma concentrations of TNF-alpha, IL-6 and IL-8 were significantly increased in patients with high PTHrP, in either the presence or absence of hypercalcemia. The concentrations of TNF-alpha and IL-6 were also significantly correlated with those of PTHrP. Our observations indicate that high plasma levels of PTHrP in cancer-bearing patients contribute not only to the development of hypercalcemia, but also to the development of the syndrome caused by an excess of pro-inflammatory cytokines.<\/jats:p>","DOI":"10.1677\/erc.0.0100403","type":"journal-article","created":{"date-parts":[[2004,12,2]],"date-time":"2004-12-02T18:44:39Z","timestamp":1102013079000},"page":"403-407","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":34,"title":["Elevation of circulating plasma cytokines in cancer patients with high plasma parathyroid hormone-related protein levels."],"prefix":"10.1530","volume":"10","author":[{"given":"S","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Hakuta","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Aiba","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Horikoshi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Hatake","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Cancer Institute Hospital, 1-37-1 Kami-Ikebukuro, Toshima-ku, Tokyo 170-8455, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Endocrine-related cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/10\/3\/14503917.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/10\/3\/403\/149141\/14503917.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/10\/3\/403\/149141\/14503917.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:49:48Z","timestamp":1783590588000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article\/10\/3\/403\/26524\/Elevation-of-circulating-plasma-cytokines-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,9,1]]}},"URL":"https:\/\/doi.org\/10.1677\/erc.0.0100403","relation":{},"ISSN":["1479-6821","1351-0088"],"issn-type":[{"value":"1479-6821","type":"electronic"},{"value":"1351-0088","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9,1]]}}}