{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:25:01Z","timestamp":1783592701389,"version":"3.55.0"},"reference-count":8,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 44-year-old woman was diagnosed with type II diabetes in 1998 and 1 year later she developed necrolytic migratory erythema, which is a specific skin lesion of glucagonoma. During the clinical investigation, a nodular 6 cm mass in the distal pancreatic region and multiple cystic liver metastases were found. She was operated on, and glucagonoma was detected and the long-acting, repeatable, octreotide treatment was started. 3 years after resection of a pancreatic glucagonoma she presented to a hospital emergency department with diabetic ketoacidosis. Hepatic multiple cystic metastases were visualized by computed tomography. During hospitalization she developed severe pulmonary embolism and deep-venous thrombosis of the lower extremities. Indium-labeled octeotide scintigraphy showed multiple cystic lesions in the liver with additional lesions in the iliocecal region, which had not been visualized by computed tomography. Despite somatostatin therapy the tumor had expanded in the liver. Arterial chemoembolization was performed but 6 months later she died.<\/jats:p>","DOI":"10.1677\/erc.1.00957","type":"journal-article","created":{"date-parts":[[2005,6,9]],"date-time":"2005-06-09T13:38:50Z","timestamp":1118324330000},"page":"449-454","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":6,"title":["Malign cystic glucagonoma presented with diabetic ketoacidosis: case report with an update"],"prefix":"10.1530","volume":"12","author":[{"given":"S M","family":"Fenkci","sequence":"first","affiliation":[{"name":"1Pamukkale University, School of Medicine, Departments of Endocrinology and Metabolism, Pamukkale University Hospital, Kinikli, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Fidan","family":"Yaylali","sequence":"additional","affiliation":[{"name":"1Pamukkale University, School of Medicine, Departments of Endocrinology and Metabolism, Pamukkale University Hospital, Kinikli, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Sermez","sequence":"additional","affiliation":[{"name":"1Pamukkale University, School of Medicine, Departments of Endocrinology and Metabolism, Pamukkale University Hospital, Kinikli, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Akdam","sequence":"additional","affiliation":[{"name":"1Pamukkale University, School of Medicine, Departments of Endocrinology and Metabolism, Pamukkale University Hospital, Kinikli, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Sabir","sequence":"additional","affiliation":[{"name":"2Pamukkale University, School of Medicine, Departments of Radiology, Pamukkale University Hospital, Kinikli, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kirac\u0327","sequence":"additional","affiliation":[{"name":"3Pamukkale University, School of Medicine, Departments of Nuclear Medicine, Pamukkale University Hospital, Kinikli, Denizli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070905534647200_ALEXANDER-ETAL-2002","doi-asserted-by":"crossref","unstructured":"Alexander\n            EK\n          , Robinson M, Staniec M & Dluhy RG 2002 Peripheral amino acid and fatty acid infusion for the treatment of necrolytic migratory erythema in the glucagonoma syndrome. Clinical Endocrinology57827\u2013831.","DOI":"10.1046\/j.1365-2265.2002.01660.x"},{"key":"2026070905534647200_ANTHONY-ETAL-1995","unstructured":"Anthony\n            LB\n          , Sharp SC & May ME 1995 Case report: diabetic ketoacidosis in a patient with glucagonoma. American Journal of Medical Science309326\u2013327."},{"key":"2026070905534647200_EL-RASSI-ETAL-1998","doi-asserted-by":"crossref","unstructured":"El Rassi\n            Z\n          , Partensky C, Valette PJ, Berger F & Chayvialle JA 1998 Necrolytic migratory erythema, first symptom of a malignant glucagonoma: treatment by long-acting somatostatin and surgical resection. Report of three cases. European Journal of Surgical Oncology24562\u2013567.","DOI":"10.1016\/S0748-7983(98)93716-7"},{"key":"2026070905534647200_KRAUSZ-ETAL-1998","unstructured":"Krausz\n            EP\n          , Kwekkeboom DJ, Bakker WH, et al.1998 Somatostatin receptor scintigraphy in the management of gastroenteropancreatic tumors. American Journal of Gastroenterology9366\u201370."},{"key":"2026070905534647200_MALLINSON-ETAL-1974","unstructured":"Mallinson\n            CN\n          , Blomm SR, Warin AP, et al.1974 A glucagonoma syndrome. Lancet21\u20135."},{"key":"2026070905534647200_PRINZ-ETAL-1981","unstructured":"Prinz\n            RA\n          , Badrinath K, Banerji M, Sparagana M, Dorsch TR & Lawrence AM 1981 Operative and chemotherapeutic management of malignant glucagon-producing tumors. Surgery90713\u2013719."},{"key":"2026070905534647200_SOGA-AND-YAKUWA-1998","doi-asserted-by":"crossref","unstructured":"Soga\n            J\n           & Yakuwa Y 1998 Glucagonomas\/diabetico-dermatogenic syndrome (DDS): a statistical evaluation of 407 reported cases. Journal of Hepatobiliary Pancreatic Surgery5312\u2013319.","DOI":"10.1007\/s005340050052"},{"key":"2026070905534647200_WERMERS-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Wermers\n            RA\n          , Fatourechi V, Wynne AG, Kvols LK & Lloyd RV 1996 The glucagonoma syndrome. Clinical and pathologic features in 21 patients. Medicine7553\u201363.","DOI":"10.1097\/00005792-199603000-00002"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/12\/2\/449\/149428\/0120449.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/12\/2\/449\/149428\/0120449.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:53:52Z","timestamp":1783590832000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article\/12\/2\/449\/26612\/Malign-cystic-glucagonoma-presented-with-diabetic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,1]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,6,1]]}},"URL":"https:\/\/doi.org\/10.1677\/erc.1.00957","relation":{},"ISSN":["1479-6821","1351-0088"],"issn-type":[{"value":"1479-6821","type":"electronic"},{"value":"1351-0088","type":"print"}],"subject":[],"published":{"date-parts":[[2005,6,1]]}}}