{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:13:41Z","timestamp":1783606421248,"version":"3.55.0"},"reference-count":15,"publisher":"Bioscientifica","issue":"4","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>A 57-year-old woman presented with an apparently obvious diagnosis of iatrogenic virilization. At the age of 51, she began a 4-year treatment with prednisone or cyclosporine, which are known to promote hair growth, for Behc\u0327et disease. At the age of 56, osteoporosis was overtreated with the anabolic steroid nandrolone. Insignificant inhibition by dexamethasone of the extremely high serum concentrations of testosterone and less high concentrations of weak androgens prompted us to search for a virilizing tumor. Computed tomography showed a 2.3 \u00d7 1.5 cm nodule in the right adrenal gland. As the patient refused surgery, virilization was treated with the antiandrogen cyproterone acetate (CPA), but for only 4 months because clinical and hormone abnormalities reversed and the tumor was no longer visible. The patient remains symptom-free. This first report of a curative effect of CPA on a purely virilizing adrenal tumor opens new avenues in the management of such tumors.<\/jats:p>","DOI":"10.1677\/erc.1.01065","type":"journal-article","created":{"date-parts":[[2005,12,1]],"date-time":"2005-12-01T14:06:49Z","timestamp":1133446009000},"page":"939-944","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":0,"title":["Disappearance of a virilizing adrenal tumor following therapy with cyproterone acetate"],"prefix":"10.1530","volume":"12","author":[{"given":"A","family":"Lasco","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Morini","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Maglitto","sequence":"additional","affiliation":[{"name":"1Surgery, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Campenni\u0300","sequence":"additional","affiliation":[{"name":"2Nuclear Medicine Division, University of Messina School of Medicine, Policlinico Universitario, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Benvenga","sequence":"additional","affiliation":[{"name":"3Section of Endocrinology, Clinical-Experimental Department of Medicine and Pharmacology, Program of Clinical and Molecular Endocrinology, Azienda Ospedaliera Gaetano Martino\u2014Messina, University of Messina School of Medicine, Policlinico Universitario, Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070909190989300_ADAMS-ETAL-1990","doi-asserted-by":"crossref","unstructured":"Adams\n              EF\n            \n          , Schrell UM, Fahlbusch R & Thierauf P 1990 Hormonal dependency of cerebral meningiomas. 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In Williams\u2019 textbook of Endocrinology, pp 819\u2013875. Eds JD Wilson, JW Foster, HM Kronenberg & PR Larsen. Philadelphia: WB Saunders."},{"key":"2026070909190989300_KARPAS-1987","unstructured":"Karpas\n              AE\n            \n          \n          1987 Iatrogenic hirsutism. In The cause and management of hirsutism. A pratical approach to the control of unwanted hair, pp 61\u201369. Eds RB Greenblatt, VB Mahesh & RD Gambrell. Lancaster: Parthenon Publishing."},{"key":"2026070909190989300_LASZLO-ETAL-2000","unstructured":"Laszlo\n              FA\n            \n          , Toth S, Kocsis J, Pavo I & Szecsi M 2000 Testosterone-secreting gonadotropin-responsive adrenal adenoma and its treatment with the antiandrogen flutamide. 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