{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:59:14Z","timestamp":1791241154025,"version":"4.1.0"},"reference-count":49,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>MicroRNAs (miRNAs) are a class of small non-coding RNAs involved in a wide range of basic processes such as cell proliferation, development, apoptosis and stress response. It has recently been found that they are also abnormally expressed in many types of human cancer. We analyzed the genome-wide miRNA expression profile in human thyroid papillary carcinomas (PTCs) using a microarray (miRNACHIP microarray) containing hundreds of human precursor and mature miRNA oligonucleotide probes. Using this approach, we found an aberrant miRNA expression profile that clearly differentiates PTCs from normal thyroid tissues. In particular, a significant increase in miRNA (miR)-221, -222 and -181b was detected in PTCs in comparison with normal thyroid tissue. These results were further confirmed by northern blot and quantitative RT-PCR analyses. Moreover, RT-PCR revealed miR-221, -222 and -181b overexpression in fine needle aspiration biopsies corresponding to thyroid nodules, which were eventually diagnosed as papillary carcinomas after surgery. Finally, miR-221, -222 and -181b overexpression was also demonstrated in transformed rat thyroid cell lines and in mouse models of thyroid carcinogenesis. Functional studies, performed by blocking miR-221 function and by overexpressing miR-221 in human PTC-derived cell lines, suggest a critical role of miR-221 overexpression in thyroid carcinogenesis. In conclusion, these data, taken together, indicate an miRNA signature associated with PTCs, and suggest miRNA deregulation as an important event in thyroid cell transformation.<\/jats:p>","DOI":"10.1677\/erc.1.01209","type":"journal-article","created":{"date-parts":[[2006,5,25]],"date-time":"2006-05-25T14:29:44Z","timestamp":1148567384000},"page":"497-508","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-8","source":"Crossref","is-referenced-by-count":406,"title":["MicroRNA deregulation in human thyroid papillary carcinomas"],"prefix":"10.1530","volume":"13","author":[{"given":"P","family":"Pallante","sequence":"first","affiliation":[{"name":"1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c\/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta\u0300 di Medicina e Chirurgia, Universita\u0300 degli Studi di Napoli \u2018Federico II\u2019, via Pansini, 5, 80131 Naples, Italy"},{"name":"2NOGEC (Naples Oncogenomic Center)-CEINGE, Biotecnologie Avanzate-Napoli and SEMM \u2013 European School of Molecular Medicine \u2013 Naples Site, via Comunale Margherita, 482, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Visone","sequence":"additional","affiliation":[{"name":"1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c\/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta\u0300 di Medicina e Chirurgia, Universita\u0300 degli Studi di Napoli \u2018Federico II\u2019, via Pansini, 5, 80131 Naples, Italy"},{"name":"3Division of Human Cancer Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, Ohio 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Ferracin","sequence":"additional","affiliation":[{"name":"4Dipartimento di Medicina Sperimentale e Diagnostica, e Centro Interdipartimentale per la Ricerca sul Cancro, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ferraro","sequence":"additional","affiliation":[{"name":"2NOGEC (Naples Oncogenomic Center)-CEINGE, Biotecnologie Avanzate-Napoli and SEMM \u2013 European School of Molecular Medicine \u2013 Naples Site, via Comunale Margherita, 482, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Berlingieri","sequence":"additional","affiliation":[{"name":"1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c\/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta\u0300 di Medicina e Chirurgia, Universita\u0300 degli Studi di Napoli \u2018Federico II\u2019, via Pansini, 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Troncone","sequence":"additional","affiliation":[{"name":"2NOGEC (Naples Oncogenomic Center)-CEINGE, Biotecnologie Avanzate-Napoli and SEMM \u2013 European School of Molecular Medicine \u2013 Naples Site, via Comunale Margherita, 482, 80145 Naples, Italy"},{"name":"5Dipartimento di Anatomia Patologica e Citopatologia, Facolta\u0300 di Medicina e Chirurgia, Universita\u0300 degli Studi di Napoli \u2018Federico II\u2019, via Pansini, 5, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Chiappetta","sequence":"additional","affiliation":[{"name":"6Istituto Nazionale dei Tumori, Fondazione Pascale, via Mariano Semmola, 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C G","family":"Liu","sequence":"additional","affiliation":[{"name":"3Division of Human Cancer Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, Ohio 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Santoro","sequence":"additional","affiliation":[{"name":"1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c\/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta\u0300 di Medicina e Chirurgia, Universita\u0300 degli Studi di Napoli \u2018Federico II\u2019, via Pansini, 5, 80131 Naples, Italy"},{"name":"2NOGEC (Naples Oncogenomic Center)-CEINGE, Biotecnologie Avanzate-Napoli and SEMM \u2013 European School of Molecular Medicine \u2013 Naples Site, via Comunale Margherita, 482, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Negrini","sequence":"additional","affiliation":[{"name":"4Dipartimento di Medicina Sperimentale e Diagnostica, e Centro Interdipartimentale per la Ricerca sul Cancro, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Croce","sequence":"additional","affiliation":[{"name":"3Division of Human Cancer Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, Ohio 43210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fusco","sequence":"additional","affiliation":[{"name":"1Dipartimento di Biologia e Patologia Cellulare e Molecolare, c\/o Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Facolta\u0300 di Medicina e Chirurgia, Universita\u0300 degli Studi di Napoli \u2018Federico II\u2019, via Pansini, 5, 80131 Naples, Italy"},{"name":"2NOGEC (Naples Oncogenomic Center)-CEINGE, Biotecnologie Avanzate-Napoli and SEMM \u2013 European School of Molecular Medicine \u2013 Naples Site, via Comunale Margherita, 482, 80145 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070905573892300_ALTUVIA-ETAL-2005","unstructured":"Altuvia\n            Y\n          , Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T & Margalit H 2005 Clustering and conservation patterns of human microRNAs. Nucleic Acids Research332697\u20132706."},{"key":"2026070905573892300_AMBROS-2004","unstructured":"Ambros\n            V\n          \n          2004 The functions of animal microRNAs. Nature431350\u2013355."},{"key":"2026070905573892300_BARTEL-2004","unstructured":"Bartel\n            DP\n          \n          2004 MicroRNAs: genomics, biogenesis, mechanism, and function. Cell116281\u2013297."},{"key":"2026070905573892300_BASKERVILLE-AND-BARTEL-2005","doi-asserted-by":"crossref","unstructured":"Baskerville\n            S\n           & Bartel DP 2005 Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA11241\u2013247.","DOI":"10.1261\/rna.7240905"},{"key":"2026070905573892300_BASOLO-ETAL-2002","doi-asserted-by":"crossref","unstructured":"Basolo\n            F\n          , Giannini R, Toniolo A, Casalone R, Nikiforova M, Pacini F, Elisei R, Miccoli P, Berti P, Faviana P et al.2002 Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET\/PTC1 rearrangement. International Journal of Cancer97608\u2013614.","DOI":"10.1002\/ijc.10116"},{"key":"2026070905573892300_BERLINGIERI-ETAL-1988","doi-asserted-by":"crossref","unstructured":"Berlingieri\n            MT\n          , Portella G, Grieco M, Santoro M & Fusco A 1988 Cooperation between the polyomavirus middle-T-antigen gene and the human c-myc oncogene in a rat thyroid epithelial differentiated cell line: model of in vitro progression. Molecular and Cellular Biology82261\u20132266.","DOI":"10.1128\/MCB.8.5.2261"},{"key":"2026070905573892300_BERLINGIERI-ETAL-1993","unstructured":"Berlingieri\n            MT\n          , Santoro M, Battaglia C, Grieco M & Fusco A 1993 The adenovirus E1A gene blocks the differentiation of a thyroid epithelial cell line; however, the neoplastic phenotype is achieved only after cooperation with other oncogenes. Oncogene8249\u2013255."},{"key":"2026070905573892300_CALIN-ETAL-2002","unstructured":"Calin\n            GA\n          , Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K et al.2002 Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. PNAS9915524\u201315529."},{"key":"2026070905573892300_CALIN-ETAL-2004A","doi-asserted-by":"crossref","unstructured":"Calin\n            GA\n          , Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S, Shimizu M, Rattan S, Bullrich F, Negrini M et al.2004a Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. PNAS1012999\u20133004.","DOI":"10.1073\/pnas.0307323101"},{"key":"2026070905573892300_CALIN-ETAL-2004B","doi-asserted-by":"crossref","unstructured":"Calin\n            GA\n          , Liu CG, Sevignani C, Ferracin M, Felli N, Dumitru CD, Shimizu M, Cimmino A, Zupo S, Dono M et al.2004b MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. PNAS10111755\u201311760.","DOI":"10.1073\/pnas.0404432101"},{"key":"2026070905573892300_CALIN-ETAL-2005","doi-asserted-by":"crossref","unstructured":"Calin\n            GA\n          , Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M et al.2005 A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. New England Journal of Medicine3531793\u20131801.","DOI":"10.1056\/NEJMoa050995"},{"key":"2026070905573892300_CULLEN-2004","unstructured":"Cullen\n            BR\n          \n          2004 Transcription and processing of human microRNA precursors. Molecular Cell16861\u2013865."},{"key":"2026070905573892300_EIS-ETAL-2005","unstructured":"Eis\n            PS\n          , Tam W, Sun L, Chadburn A, Li Z, Gomez MF, Lund E & Dahlberg JE 2005 Accumulation of miR-155 and BIC RNA in human B cell lymphomas. PNAS1023627\u20133632."},{"key":"2026070905573892300_FABIEN-ETAL-1994","doi-asserted-by":"crossref","unstructured":"Fabien\n            N\n          , Fusco A, Santoro M, Barbier Y, Dubois PM & Paulin C 1994 Description of a human papillary thyroid carcinoma cell line. Morphologic study and expression of tumoral markers. Cancer732206\u20132212.","DOI":"10.1002\/1097-0142(19940415)73:8<2206::AID-CNCR2820730828>3.0.CO;2-M"},{"key":"2026070905573892300_FELLI-ETAL-2005","doi-asserted-by":"crossref","unstructured":"Felli\n            N\n          , Fontana L, Pelosi E, Botta R, Bonci D, Facchiano F, Liuzzi F, Lulli V, Morsilli O, Santoro S et al.2005 MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. PNAS10218081\u201318086.","DOI":"10.1182\/blood.V106.11.830.830"},{"key":"2026070905573892300_FUSCO-ETAL-1987","doi-asserted-by":"crossref","unstructured":"Fusco\n            A\n          , Berlingieri MT, Di Fiore PP, Portella G, Grieco M & Vecchio G 1987 One- and two-step transformation of rat thyroid epithelial cells by retroviral oncogenes. Molecular and Cellular Biology73365\u20133370.","DOI":"10.1128\/mcb.7.9.3365-3370.1987"},{"key":"2026070905573892300_GREGORY-AND-SHIEKHATTAR-2005","doi-asserted-by":"crossref","unstructured":"Gregory\n            RI\n           & Shiekhattar R 2005 MicroRNA biogenesis and cancer. Cancer Research653509\u20133512.","DOI":"10.1158\/0008-5472.CAN-05-0298"},{"key":"2026070905573892300_HE-ETAL-2005","doi-asserted-by":"crossref","unstructured":"He\n            H\n          , Jazdzewski K, Li W, Liyanarachchi S, Nagy R, Volinia S, Calin GA, Liu CG, Franssila K, Suster S et al.2005 The role of microRNA genes in papillary thyroid carcinoma. PNAS10219075\u201319080.","DOI":"10.1073\/pnas.0509603102"},{"key":"2026070905573892300_HE-AND-HANNON-2004","doi-asserted-by":"crossref","unstructured":"He\n            L\n           & Hannon GJ 2004 MicroRNAs: small RNAs with a big role in gene regulation. Nature Reviews Genetics5522\u2013531.","DOI":"10.1038\/nrg1379"},{"key":"2026070905573892300_HEDINGER-ETAL-1989","doi-asserted-by":"crossref","unstructured":"Hedinger\n            C\n          , Williams D & Sobin LH 1989 The WHO histological classification of thyroid tumours: a commentary on the second edition. Cancer63908\u2013911.","DOI":"10.1002\/1097-0142(19890301)63:5<908::AID-CNCR2820630520>3.0.CO;2-I"},{"key":"2026070905573892300_IORIO-ETAL-2005","doi-asserted-by":"crossref","unstructured":"Iorio\n            MV\n          , Ferracin M, Liu CG, Veronese A, Spizzo R, Sabbioni S, Magri E, Pedriali M, Fabbri M, Campiglio M et al.2005 MicroRNA gene expression deregulation in human breast cancer. Cancer Research657065\u20137070.","DOI":"10.1158\/0008-5472.CAN-05-1783"},{"key":"2026070905573892300_JOHN-ETAL-2004","doi-asserted-by":"crossref","unstructured":"John\n            B\n          , Enright AJ, Aravin A, Tuschl T, Sander C & Marks DS 2004 Human MicroRNA targets. PLoS Biology2e363.","DOI":"10.1371\/journal.pbio.0020363"},{"key":"2026070905573892300_JOHNSON-ETAL-2005","doi-asserted-by":"crossref","unstructured":"Johnson\n            SM\n          , Grosshans H, Shingara J, Byrom M, Jarvis R, Cheng A, Labourier E, Reinert KL, Brown D & Slack FJ 2005 RAS is regulated by the let-7 microRNA family. Cell120635\u2013647.","DOI":"10.1016\/j.cell.2005.01.014"},{"key":"2026070905573892300_KREK-ETAL-2005","doi-asserted-by":"crossref","unstructured":"Krek\n            A\n          , Grun D, Poy MN, Wolf R, Rosenberg L, Epstein EJ, MacMenamin P, da Piedade I, Gunsalus KC, Stoffel M et al.2005 Combinatorial microRNA target predictions. Nature Genetics37495\u2013500.","DOI":"10.1038\/ng1536"},{"key":"2026070905573892300_LAGOS-QUINTANA-ETAL-2003","doi-asserted-by":"crossref","unstructured":"Lagos-Quintana\n            M\n          , Rauhut R, Meyer J, Borkhardt A & Tuschl T 2003 New microRNAs from mouse and human. RNA9175\u2013179.","DOI":"10.1261\/rna.2146903"},{"key":"2026070905573892300_LEDENT-ETAL-1995","unstructured":"Ledent\n            C\n          , Marcotte A, Dumont JE, Vassart G & Parmentier M 1995 Differentiated carcinomas develop as a consequence of the thyroid specific expression of a thyroglobulin-human papillomavirus type 16 E7 transgene. Oncogene101789\u20131797."},{"key":"2026070905573892300_LEWIS-ETAL-2003","doi-asserted-by":"crossref","unstructured":"Lewis\n            BP\n          , Shih IH, Jones-Rhoades MW, Bartel DP & Burge CB 2003 Prediction of mammalian microRNA targets. Cell115787\u2013798.","DOI":"10.1016\/S0092-8674(03)01018-3"},{"key":"2026070905573892300_LIANG-ETAL-2005","doi-asserted-by":"crossref","unstructured":"Liang\n            RQ\n          , Li W, Li Y, Tan CY, Li JX, Jin YX & Ruan KC 2005 An oligonucleotide microarray for microRNA expression analysis based on labeling RNA with quantum dot and nanogold probe. Nucleic Acids Research33e17.","DOI":"10.1093\/nar\/gni019"},{"key":"2026070905573892300_LIU-ETAL-2004","doi-asserted-by":"crossref","unstructured":"Liu\n            CG\n          , Calin GA, Meloon B, Gamliel N, Sevignani C, Ferracin M, Dumitru CD, Shimizu M, Zupo S, Dono M et al.2004 An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues. PNAS1019740\u20139744.","DOI":"10.1073\/pnas.0403293101"},{"key":"2026070905573892300_MCMANUS-2003","unstructured":"McManus\n            MT\n          \n          2003 MicroRNAs and cancer. Seminars in Cancer Biology13253\u2013258."},{"key":"2026070905573892300_MEISTER-ETAL-2004","doi-asserted-by":"crossref","unstructured":"Meister\n            G\n          , Landthaler M, Dorsett Y & Tuschl T 2004 Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing. RNA10544\u2013550.","DOI":"10.1261\/rna.5235104"},{"key":"2026070905573892300_METZLER-ETAL-2004","doi-asserted-by":"crossref","unstructured":"Metzler\n            M\n          , Wilda M, Busch K, Viehmann S & Borkhardt A 2004 High expression of precursor microRNA-155\/BIC RNA in children with Burkitt lymphoma. Genes, Chromosomes and Cancer39167\u2013169.","DOI":"10.1002\/gcc.10316"},{"key":"2026070905573892300_MICHAEL-ETAL-2003","unstructured":"Michael\n            MZ\n          , O\u2019Connor SM, van Holst Pellekaan NG, Young GP & James RJ 2003 Reduced accumulation of specific microRNAs in colorectal neoplasia. Molecular Cancer Research1882\u2013891."},{"key":"2026070905573892300_NATALI-ETAL-1995","unstructured":"Natali\n            PG\n          , Berlingieri MT, Nicotra MR, Fusco A, Santoro E, Bigotti A & Vecchio G 1995 Transformation of thyroid epithelium is associated with loss of c-kit receptor. Cancer Research551787\u20131791."},{"key":"2026070905573892300_NELSON-ETAL-2004","doi-asserted-by":"crossref","unstructured":"Nelson\n            PT\n          , Baldwin DA, Scearce LM, Oberholtzer JC, Tobias JW & Mourelatos Z 2004 Microarray-based, high-throughput gene expression profiling of microRNAs. Nature Methods1155\u2013161.","DOI":"10.1038\/nmeth717"},{"key":"2026070905573892300_PANG-ETAL-1989","doi-asserted-by":"crossref","unstructured":"Pang\n            XP\n          , Hershman JM, Chung M & Pekary AE 1989 Characterization of tumor necrosis factor-alpha receptors in human and rat thyroid cells and regulation of the receptors by thyrotropin. Endocrinology1251783\u20131788.","DOI":"10.1210\/endo-125-4-1783"},{"key":"2026070905573892300_PILLAI-2005","unstructured":"Pillai\n            RS\n          \n          2005 MicroRNA function: multiple mechanisms for a tiny RNA? RNA111753\u20131761."},{"key":"2026070905573892300_POWELL-JR-ETAL-1998","unstructured":"Powell\n            DJ\n           Jr, Russell J, Nibu K, Li G, Rhee E, Liao M, Goldstein M, Keane WM, Santoro M, Fusco A et al.1998 The RET\/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids. Cancer Research585523\u20135528."},{"key":"2026070905573892300_RHOADES-ETAL-2002","doi-asserted-by":"crossref","unstructured":"Rhoades\n            MW\n          , Reinhart BJ, Lim LP, Burge CB, Bartel B & Bartel DP 2002 Prediction of plant microRNA targets. Cell110513\u2013520.","DOI":"10.1016\/S0092-8674(02)00863-2"},{"key":"2026070905573892300_RUSSELL-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Russell\n            JP\n          , Powell DJ, Cunnane M, Greco A, Portella G, Santoro M, Fusco A & Rothstein JL 2000 The TRK-T1 fusion protein induces neoplastic transformation of thyroid epithelium. Oncogene195729\u20135735.","DOI":"10.1038\/sj.onc.1203922"},{"key":"2026070905573892300_SANTORO-ETAL-1993","unstructured":"Santoro\n            M\n          , Melillo RM, Berlingieri MT, Grieco M, Vecchio G & Fusco A 1993 The TRK and RET tyrosine-kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line. Cell Growth and Differentiation477\u201384."},{"key":"2026070905573892300_SCHMITTGEN-ETAL-2004","doi-asserted-by":"crossref","unstructured":"Schmittgen\n            TD\n          , Jiang J, Liu Q & Yang L 2004 A high-throughput method to monitor the expression of microRNA precursors. Nucleic Acids Research32e43.","DOI":"10.1093\/nar\/gnh040"},{"key":"2026070905573892300_SEMPERE-ETAL-2004","doi-asserted-by":"crossref","unstructured":"Sempere\n            LF\n          , Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E & Ambros V 2004 Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biology5R13.","DOI":"10.1186\/gb-2004-5-3-r13"},{"key":"2026070905573892300_TAKAMIZAWA-ETAL-2004","unstructured":"Takamizawa\n            J\n          , Konishi H, Yanagisawa K, Tomida S, Osada H, Endoh H, Harano T, Yatabe Y, Nagino M, Nimura Y et al.2004 Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Research643753\u20133756."},{"key":"2026070905573892300_TANAKA-ETAL-1987","unstructured":"Tanaka\n            J\n          , Ogura T, Sato H & Datano M 1987 Establishment and biological characterization of an in vitro human cytomegalovirus latency model. Virology16162\u201372."},{"key":"2026070905573892300_TANG-ETAL-2003","doi-asserted-by":"crossref","unstructured":"Tang\n            G\n          , Reinhart BJ, Bartel DP & Zamore PD 2003 A biochemical framework for RNA silencing in plants. Genes and Development1749\u201363.","DOI":"10.1101\/gad.1048103"},{"key":"2026070905573892300_TRONCONE-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Troncone\n            G\n          , Fulciniti F, Zeppa P, Vetrani A, Caleo A, Palombini L 2000 Cyclin-dependent kinase inhibitor p27(Kip1) expression in thyroid cells obtained by fine-needle aspiration biopsy: a preliminary report. Diagnostic Cytopathology2377\u201381.","DOI":"10.1002\/1097-0339(200008)23:2<77::AID-DC2>3.0.CO;2-6"},{"key":"2026070905573892300_WYNFORD-THOMAS-1997","unstructured":"Wynford-Thomas\n            D\n          \n          1997 Origin and progression of thyroid epithelial tumours. Cellular and molecular mechanisms. Hormone Research47145\u2013157."},{"key":"2026070905573892300_ZEPPA-ETAL-1990","doi-asserted-by":"crossref","unstructured":"Zeppa\n            P\n          , Vetrani A, Marino M, Fulciniti F, Boschi R, deRosa G & Palombini L 1990 Fine needle aspiration of medullary thyroid carcinoma: a review of 18 cases. Cytopathology135\u201344.","DOI":"10.1111\/j.1365-2303.1990.tb00324.x"}],"container-title":["Endocrine-Related Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/erc.bioscientifica.com\/view\/journals\/erc\/13\/2\/0130497.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/13\/2\/497\/150013\/0130497.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article-pdf\/13\/2\/497\/150013\/0130497.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:57:48Z","timestamp":1783591068000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/erc\/article\/13\/2\/497\/26696\/MicroRNA-deregulation-in-human-thyroid-papillary"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,1]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1677\/erc.1.01209","relation":{},"ISSN":["1479-6821","1351-0088"],"issn-type":[{"value":"1479-6821","type":"electronic"},{"value":"1351-0088","type":"print"}],"subject":[],"published":{"date-parts":[[2006,6,1]]}}}