{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:13:44Z","timestamp":1783516424676,"version":"3.55.0"},"reference-count":55,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Retinoid-related orphan receptor \u03b3 (ROR\u03b3) is an orphan nuclear hormone receptor (NR) that is preferentially expressed in skeletal muscle and several other tissues, including pancreas, thymus, prostate, liver and testis. Surprisingly, the specific role of ROR\u03b3 in skeletal muscle, a peripheral tissue, has not been examined. Muscle is one of the most energy demanding tissues which accounts for ~40% of the total body mass and energy expenditure, &amp;gt;75% of glucose disposal and relies heavily on \u03b2-oxidation of fatty acids. We hypothesize that ROR\u03b3 regulates metabolism in this major mass lean tissue. This hypothesis was examined by gain and loss of function studies in an in vitro mouse skeletal muscle cell culture model. We show that ROR\u03b3 mRNA and protein are dramatically induced during skeletal muscle cell differentiation. We utilize stable ectopic over-expression of VP16-ROR\u03b3 (gain of function), native ROR\u03b3 and ROR\u03b3\u0394H12 (loss of function) vectors to modulate ROR\u03b3 mRNA expression and function. Ectopic VP16 (herpes simplex virus transcriptional activator)-ROR\u03b3 and native ROR\u03b3 expression increases ROR\u03b1 mRNA expression. Candidate-driven expression profiling of lines that ectopically express the native and variant forms of ROR\u03b3 suggested that this orphan NR has a function in regulating the expression of genes that control lipid homeostasis (fatty acid-binding protein 4, CD36 (fatty acid translocase), lipoprotein lipase and uncoupling protein 3), carbohydrate metabolism (GLUT5 (fructose transporter), adiponectin receptor 2 and interleukin 15 (IL-15)) and muscle mass (including myostatin and IL-15). Surprisingly, the investigation revealed a function for ROR\u03b3 in the pathway that regulates production of reactive oxygen species.<\/jats:p>","DOI":"10.1677\/jme.1.00010","type":"journal-article","created":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T13:36:57Z","timestamp":1183124217000},"page":"29-44","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":41,"title":["Retinoid-related orphan receptor \u03b3 regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production"],"prefix":"10.1530","volume":"39","author":[{"given":"Suryaprakash","family":"Raichur","sequence":"first","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland St Lucia, 4072, Queensland, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lau","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland St Lucia, 4072, Queensland, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart","family":"Staels","sequence":"additional","affiliation":[{"name":"Departement d\u2019Atherosclerose, Institut Pasteur de Lille, Inserm, U545, Lille F-59019, France 2"},{"name":"Faculte de Pharmacie et Faculte de Medecine, Universite de Lille 2, Lille F-59019, France 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E O","family":"Muscat","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, University of Queensland St Lucia, 4072, Queensland, Australia 1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2007,5,3]]},"reference":[{"key":"2026070808174033400_ADELMANT-ETAL-1996","doi-asserted-by":"crossref","unstructured":"Adelmant\n              G\n            \n          , Begue A, Stehelin D & Laudet V 1996 A functional Reverb\u03b1 responsive element located in the human Rev-erb\u03b1 promoter mediates a repressing activity. 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