{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:43:59Z","timestamp":1791207839952,"version":"4.1.0"},"reference-count":41,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In this study we looked at the epididymides and spermatozoa of mice knocked-out for nuclear oxysterol receptors (LXR). We have shown that LXR-deficient mice exhibited upon ageing a severe disruption of their caput epididymides associated with abnormal accumulation of neutral lipids. The epididymis defaults were correlated with sperm head fragility and infertility. In agreement with the observed caput defect in transgenic animals in which both LXR\u03b1 and LXR\u03b2 isoforms were disrupted, we have shown here that both receptors are expressed in caput and cauda epididymides regions. LXR\u03b2 was predominantly expressed throughout the mouse epididymis while the expression of LXR\u03b1 was weaker. In addition, the expression of selected genes that can be considered as markers of adult epididymis function was monitored via Northern blots in the different single and double LXR-deficient backgrounds. Altogether, the data presented here suggest that LXR receptors are important actors in epididymis function.<\/jats:p>","DOI":"10.1677\/jme.1.01515","type":"journal-article","created":{"date-parts":[[2004,12,2]],"date-time":"2004-12-02T18:43:59Z","timestamp":1102013039000},"page":"361-375","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":51,"title":["Nuclear oxysterol receptors, LXRs, are involved in the maintenance of mouse caput epididymidis structure and functions"],"prefix":"10.1530","volume":"33","author":[{"given":"J-M","family":"Frenoux","sequence":"first","affiliation":[{"name":"Epididyme et Maturation des Game\u0300tes, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Vernet","sequence":"additional","affiliation":[{"name":"Epididyme et Maturation des Game\u0300tes, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D H","family":"Volle","sequence":"additional","affiliation":[{"name":"Physiologie Compare\u0301e et Endocrinologie Mole\u0301culaire, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Britan","sequence":"additional","affiliation":[{"name":"Epididyme et Maturation des Game\u0300tes, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Saez","sequence":"additional","affiliation":[{"name":"Epididyme et Maturation des Game\u0300tes, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Kocer","sequence":"additional","affiliation":[{"name":"Epididyme et Maturation des Game\u0300tes, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Henry-Berger","sequence":"additional","affiliation":[{"name":"Physiologie Compare\u0301e et Endocrinologie Mole\u0301culaire, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Mangelsdorf","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9050, USA 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-M A","family":"Lobaccaro","sequence":"additional","affiliation":[{"name":"Physiologie Compare\u0301e et Endocrinologie Mole\u0301culaire, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J R","family":"Drevet","sequence":"additional","affiliation":[{"name":"Epididyme et Maturation des Game\u0300tes, CNRS UMR 6547 GEEM, Universite\u0301 Blaise Pascal, 24, avenue des Landais, 63177 Aubie\u0300re cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070811423497800_ABOU-HAILA-AND-FAIN-MAUREL-1984","doi-asserted-by":"crossref","unstructured":"Abou-Haila\n              A\n            \n           & Fain-Maurel MA 1984 Regional differences of the proximal part of mouse epididymis: morphological and histological characterization. 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