{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:20:55Z","timestamp":1783527655650,"version":"3.55.0"},"reference-count":29,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2005,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Decreased suppressors of cytokine signaling (SOCS) activity in human gestational tissues may play a part in the onset\/progression of term labor. Since SOCS proteins negatively regulate cytokine-mediated inflammatory processes, we hypothesized that SOCS proteins are elevated in gestational tissues from spontaneous preterm deliveries with intrauterine infection. SOCS1, \u22122 and \u22123 mRNAs and proteins were detectable by RT-PCR and immunoblotting respectively, in preterm amnion, choriodecidua and placenta, irrespective of infection status. Immunoperoxidase staining localized SOCS1, \u22122 and \u22123 to all cell types of the gestational membranes, with infiltrating leukocytes reacting strongly in infected tissues. In villous placenta, SOCS was immunolocalized to the syncytiotrophoblast with marked staining of round mesenchymal cells, possibly Hofbauer cells. Nuclear SOCS staining was seen in amnion, chorion and placental syncytiotrophoblasts. SOCS proteins were, in general, significantly more abundant in placenta compared with amnion or choriodecidua. Placental SOCS1 and interleukin-1\u03b2 concentrations were positively correlated (r2=0.47; P&amp;lt;0.05). However, no changes in SOCS levels in any tissues were observed with intrauterine infection. The relatively large amounts of SOCS proteins in the placenta may reflect a placenta-specific immunoprotective response to minimize the elaboration and effects of cytokines with potential to harm the placenta and fetus. Lack of labor-associated changes in SOCS levels suggests that the regulation of SOCS expression in preterm gestational tissues differs from those at term, perhaps reflecting roles in regulating placental somatotropic responses.<\/jats:p>","DOI":"10.1677\/jme.1.01767","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T13:37:55Z","timestamp":1123508275000},"page":"165-175","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":8,"title":["Suppressors of cytokine signaling proteins in human preterm placental tissues"],"prefix":"10.1530","volume":"35","author":[{"given":"M","family":"Blumenstein","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Thomas Building, University of Auckland, Private Bag 92019, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J A","family":"Keelan","sequence":"additional","affiliation":[{"name":"Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand 1"},{"name":"Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand 2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Bowen-Shauver","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, USA 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M D","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Liggins Institute, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand 1"},{"name":"Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand 2"},{"name":"National Research Centre for Growth and Development, University of Auckland, New Zealand 4"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070811401224300_BARKAI-ETAL-2000","doi-asserted-by":"crossref","unstructured":"Barkai\n              U\n            \n          , Prigent-Tessier A, Tessier C, Gibori GB & Gibori G 2000 Involvement of SOCS-1, the suppressor of cytokine signaling, in the prevention of prolactin-responsive gene expression in decidual cells. Molecular Endocrinology14554\u2013563.","DOI":"10.1210\/mend.14.4.0437"},{"key":"2026070811401224300_BLUMENSTEIN-ETAL-2002","doi-asserted-by":"crossref","unstructured":"Blumenstein\n              M\n            \n          , Bowen-Shauver JM, Keelan JA & Mitchell MD 2002 Identification of suppressors of cytokine signaling (SOCS) proteins in human gestational tissues: differential regulation is associated with the onset of labor. Journal of Clinical Endocrinology and Metabolism871094\u20131097.","DOI":"10.1210\/jcem.87.3.8463"},{"key":"2026070811401224300_BOWEN-ETAL-2002","doi-asserted-by":"crossref","unstructured":"Bowen\n              JM\n            \n          , Chamley L, Keelan JA & Mitchell MD 2002 Cytokines of the placenta and extra-placental membranes: roles and regulation during human pregnancy and parturition. 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