{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:57:55Z","timestamp":1790243875874,"version":"4.1.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Daily rhythms of melatonin production are controlled by changes in the activity of arylalkylamine-N-acetyltransferase (AANAT). Zebrafish possess two aanats, aanat1 and aanat2; the former is expressed only in the retina and the latter is expressed in both the retina and the pineal gland. Here, their differential expression and regulation were studied using transcript quantification and transient and stable in vivo and in vitro transfection assays. In the pineal gland, the aanat2 promoter exhibited circadian clock-controlled activity, as indicated by circadian rhythms of Enhanced green fluorescent protein (EGFP) mRNA in AANAT2:EGFP transgenic fish. In vivo transient expression analyses of the aanat2 promoter indicated that E-box and photoreceptor conserved elements (PCE) are required for expression in the pineal gland. In the retina, the expression of both genes was characterized by a robust circadian rhythm of their transcript levels. In constant darkness, the rhythmic expression of retinal aanat2 persisted while the aanat1 rhythm disappeared; indicating that the former is controlled by a circadian clock and the latter is also light driven. In the light-entrainable clock-containing PAC-2 zebrafish cell line, both stably transfected aanat1 and aanat2 promoters exhibited a clock-controlled circadian rhythm, characteristic for an E-box-driven expression. Transient co-transfection experiments in NIH-3T3 cells revealed that the two, E-box- and PCE-containing, promoters are driven by the synergistic action of BMAL\/CLOCK and orthehodenticle homeobox 5. This study has revealed a shared mechanism for the regulation of two related genes, yet describes their differential phases and photic responses which may be driven by other gene-specific regulatory mechanisms and tissue-specific transcription factor profiles.<\/jats:p>","DOI":"10.1677\/jme.1.01893","type":"journal-article","created":{"date-parts":[[2006,4,4]],"date-time":"2006-04-04T12:28:39Z","timestamp":1144153719000},"page":"337-347","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-6","source":"Crossref","is-referenced-by-count":64,"title":["Zebrafish arylalkylamine-\n                    <i>N<\/i>\n                    -acetyltransferase genes \u2013 targets for regulation of the circadian clock"],"prefix":"10.1530","volume":"36","author":[{"given":"L","family":"Appelbaum","sequence":"first","affiliation":[{"name":"Department of Zoology and 1"},{"name":"Faculty of Life Sciences, Bar-Ilan University, Ramat Gan 52900, Israel 3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Vallone","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fur Entwicklungsbiologie, Spemannstrasse 35-39, Tubingen, D-72076 Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Anzulovich","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biological Sciences, Faculty of Chemistry, Biochemistry and Pharmacy, San Luis University, Chacabuco y Pedernera, Edif. El Barco, 2do. piso., San Luis, CP 5700 Argentina 5"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Ziv","sequence":"additional","affiliation":[{"name":"Department of Zoology and 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tom","sequence":"additional","affiliation":[{"name":"Israel Oceanographic and Limmnological Research, Haifa 31080, Israel 6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N S","family":"Foulkes","sequence":"additional","affiliation":[{"name":"Max-Planck-Institut fur Entwicklungsbiologie, Spemannstrasse 35-39, Tubingen, D-72076 Germany 4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Gothilf","sequence":"additional","affiliation":[{"name":"Department of Neurobiochemisty, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel 2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"2026070808091105500_AMORES-ETAL-1998","unstructured":"Amores\n            A\n          , Force A, Yan YL, Joly L, Amemiya C, Fritz A, Ho RK, Langeland J, Prince V, Wang YL, Westerfield M, Ekker M & Postlethwait JH 1998 Zebrafish hox clusters and vertebrate genome evolution. 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