{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:18:30Z","timestamp":1784557110242,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:p>The aim of our study was to investigate the ability of keratinocyte growth factor (KGF; palifermin) in regulating \u03b2-cell growth in normal newborn rats and in rats with neonatal diabetes. Wistar rats were injected with streptozotocin (STZ) to induce diabetes on the dayof birth. From days 2 to 6 after birth, animals received a daily s.c. injection of KGF (STZ\/KGF group) and at the dose of 3 mg\/kg body weight or saline solution (STZ groups). A group of non-diabetic Wistar rats was treated either with saline (Wistar group) or with KGF from days 2 to 6 after birth at the dose of 3 mg\/kg body weight (Wistar\/KGF group). \u03b2-cell mass was measured at day 7 after birth in all groups. \u03b2- and ductal cells replication were measured in all groups and apoptosis was assessed in the pancreas of 2-, 4-, and 7-day-old STZ and STZ\/KGF rats. The total \u03b2-cell mass of the 7-day-old KGF\/STZ neonates was significantly increased compared with that of age-matched STZ rats. \u03b2-cell replication rate was decreased at day 2 in the STZ\/KGF group and was similar in the 4- and 7-day-old rats from STZ and STZ\/KGF groups. Duct cell replication was significantly increased in the pancreas of 2- and 4-day-old KGF\/STZ neonates when compared with that of age-matched rats from STZ control group. The rate of apoptosis in the neonatal pancreases of STZ and KGF\/STZ groups was not significantly different. In non-diabetic Wistar rats, KGF treatment led to a slight but significant increase in duct cell proliferation at day 2 without significant changes in the total \u03b2-cell mass in the 7-day-old rats. We provide evidence for a growth-promoting effect of KGF during \u03b2-cell regeneration in neonatal diabetic rats. KGF exerts strong mitogenic effect on the pancreatic duct cells, thus expanding the population of precursor cells that subsequently differentiate into insulin-producing \u03b2-cells.<\/jats:p>","DOI":"10.1677\/joe-07-0098","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T14:39:10Z","timestamp":1192804750000},"page":"333-340","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":15,"title":["Early administration of keratinocyte growth factor improves \u03b2-cell regeneration in rat with streptozotocin-induced diabetes"],"prefix":"10.1530","volume":"195","author":[{"given":"Jamileh","family":"Movassat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Portha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/195\/2\/1940333.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/195\/2\/1940333.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:52:59Z","timestamp":1784555579000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/195\/2\/333-340\/21531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1677\/joe-07-0098","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}