{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:31Z","timestamp":1784557231020,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n                    Exposure to 2,3,7,8-tetrachlorodibenzo-\n                    <jats:italic>p<\/jats:italic>\n                    -dioxin (TCDD) during the fetal and neonatal periods has been indicated to alter the development of the offspring later in life. In this study, we determined whether perinatal exposure to a low dose of TCDD affects the onset of puberty in the female offspring of Long-Evans hooded rats. On day 15 of gestation, pregnant female rats were administered TCDD by gavage at a single dose of 0 (vehicle), 200, or 800\u200ang\/kg b.w. In the female offspring born to dams administered with TCDD at either 200 or 800\u200ang\/kg b.w., the vaginal opening and first estrus occurred \u223c4\u20137 days earlier than in the offspring born to vehicle-treated animals. The ovarian weight gain was also accelerated following exposure to TCDD in a dose-dependent manner. We next examined the ovarian compensatory hypertrophy (OCH) as an indicator of the maturation of the LH\/GnRH-generating system in the pituitary and the hypothalamus. Exposure to TCDD accelerated the onset of OCH in the female offspring in a dose-dependent manner. In particular, in the offspring born to the dams exposed to TCDD at 800\u200ang\/kg b.w., hypertrophy, which is characterized by hyperovulation and a marked increase in the weight of the remaining ovary after hemi-ovariectomy, was observed on postnatal days 27\u201330, which was 10 days earlier than in the offspring born to the vehicle-treated dams. These results indicate that perinatal exposure to a low dose of TCDD induces precocious puberty, including early maturation of the hypothalamic\u2013pituitary axis, the gonads and genitals, in female Long-Evans hooded rats.\n                  <\/jats:p>","DOI":"10.1677\/joe-08-0062","type":"journal-article","created":{"date-parts":[[2008,4,23]],"date-time":"2008-04-23T03:47:56Z","timestamp":1208922476000},"page":"351-358","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":19,"title":["Perinatal exposure of female rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin induces central precocious puberty in the offspring"],"prefix":"10.1530","volume":"197","author":[{"given":"Masaki","family":"Kakeyama","sequence":"first","affiliation":[{"name":"1Division of Environmental Health SciencesGraduate School of Medicine, Center for Disease Biology and Integrative Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan2National Institute for Environmental StudiesResearch Center for Environmental Risk, Tsukuba 305-8506, Japan"},{"name":"1Division of Environmental Health SciencesGraduate School of Medicine, Center for Disease Biology and Integrative Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan2National Institute for Environmental StudiesResearch Center for Environmental Risk, Tsukuba 305-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideko","family":"Sone","sequence":"additional","affiliation":[{"name":"1Division of Environmental Health SciencesGraduate School of Medicine, Center for Disease Biology and Integrative Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan2National Institute for Environmental StudiesResearch Center for Environmental Risk, Tsukuba 305-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Tohyama","sequence":"additional","affiliation":[{"name":"1Division of Environmental Health SciencesGraduate School of Medicine, Center for Disease Biology and Integrative Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan2National Institute for Environmental StudiesResearch Center for Environmental Risk, Tsukuba 305-8506, Japan"},{"name":"1Division of Environmental Health SciencesGraduate School of Medicine, Center for Disease Biology and Integrative Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan2National Institute for Environmental StudiesResearch Center for Environmental Risk, Tsukuba 305-8506, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/197\/2\/351.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/197\/2\/351.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:53:57Z","timestamp":1784555637000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/197\/2\/351-358\/21585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,3]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1677\/joe-08-0062","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,3]]}}}