{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:36:57Z","timestamp":1791103017773,"version":"4.1.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>\n                    Mutations of the multiple endocrine neoplasia type 1 (\n                    <jats:italic>MEN1<\/jats:italic>\n                    ) gene predispose patients to MEN1 that affects mainly endocrine tissues, suggesting important physiological functions of the gene in adult endocrine cells. Homozygous disruption of\n                    <jats:italic>Men1<\/jats:italic>\n                    in mice causes embryonic lethality, whereas the eventual involvement of the gene in embryonic development of the endocrine cells remains unknown. Here, we show that homozygous\n                    <jats:italic>Men1<\/jats:italic>\n                    knockout mice demonstrate a reduced number of glucagon-positive cells in the E12.5 pancreatic bud associated with apoptosis, whereas the exocrine pancreas development in these mice is not affected. Our data suggest that menin is involved in the survival of the early pancreatic endocrine cells during the first developmental transition. Furthermore, chimerism assay revealed that menin has an autonomous and specific effect on the development of islet cells. In addition, using pancreatic bud culture mimicking the differentiation of \u03b1- and \u03b2-cells during the second transition, we show that loss of menin leads to the failure of endocrine cell development, altered pancreatic structure and a markedly decreased number of cells expressing neurogenin 3, indicating that menin is also required at this stage of the endocrine pancreas development. Taken together, our results suggest that menin plays an indispensable role in the development of the pancreatic endocrine cells.\n                  <\/jats:p>","DOI":"10.1677\/joe-08-0289","type":"journal-article","created":{"date-parts":[[2008,9,4]],"date-time":"2008-09-04T20:24:44Z","timestamp":1220559884000},"page":"287-298","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":27,"title":["Tumour suppressor menin is essential for development of the pancreatic endocrine cells"],"prefix":"10.1530","volume":"199","author":[{"given":"Sandra","family":"Fontani\u00e8re","sequence":"first","affiliation":[{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"},{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Duvilli\u00e9","sequence":"additional","affiliation":[{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Scharfmann","sequence":"additional","affiliation":[{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Carreira","sequence":"additional","affiliation":[{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"},{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"},{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Xian","family":"Zhang","sequence":"additional","affiliation":[{"name":"1CNRS UMR2501Laboratoire G\u00e9n\u00e9tique Mol\u00e9culaire, Signalisation et Cancer, Universit\u00e9 Claude Bernard Lyon, Lyon F-69008, France2International Agency for Research on Cancer69008 Lyon, France3INSERM U845Facult\u00e9 de M\u00e9decine, Centre de Recherche Croissance et Signalisation, Universit\u00e9 Paris Descartes, H\u00f4pital Necker, 75015 Paris, France4Leibniz Institute for Age ResearchFritz Lipmann Institute (FLI), 07745 Jena, Germany5Faculty of Biology and PharmacyFriedlich-Schiller-University, 07743 Jena, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of 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