{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:42Z","timestamp":1784557242382,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>\n                    The growth-retarded (\n                    <jats:italic>grt<\/jats:italic>\n                    ) mouse shows thyroid dysfunction-related hyporesponsiveness to TSH. Thyroid hormone is a critical regulator of metabolism in many cells; thus, derangement of thyroid function affects many organs and systems. Experiments were conducted focusing on the function of the pancreatic islets in\n                    <jats:italic>grt<\/jats:italic>\n                    mice. We showed occurrence of a fasting hyperglycemia and a decreased plasma insulin level response to a glucose load in\n                    <jats:italic>grt<\/jats:italic>\n                    mice, despite normal insulin molecules being stored in secretory granules of pancreatic islets. We also demonstrated a reduction of insulin secretion in response to glucose administration from islets of\n                    <jats:italic>grt<\/jats:italic>\n                    mice\n                    <jats:italic>in vitro<\/jats:italic>\n                    , while the insulin release in response to KCl stimulation was comparable to that in normal mice, indicating that the isolated islets from\n                    <jats:italic>grt<\/jats:italic>\n                    mice have normal ATP-sensitive K\n                    <jats:sup>+<\/jats:sup>\n                    channels and postchannel activity. The mRNA expression levels of glucose transporter 2 and glucokinase in the islets of\n                    <jats:italic>grt<\/jats:italic>\n                    mice were similar to those in normal mice. Triiodothyronine administration to\n                    <jats:italic>grt<\/jats:italic>\n                    mice improved insulin secretion very slightly. On the other hand, mRNA for tyrosylprotein sulfotransferase 2 (\n                    <jats:italic>Tpst2<\/jats:italic>\n                    ) was found to be expressed in the pancreatic islets of\n                    <jats:italic>grt<\/jats:italic>\n                    mice. Considering that\n                    <jats:italic>Tpst2<\/jats:italic>\n                    is the responsible gene of\n                    <jats:italic>grt<\/jats:italic>\n                    mice, mutation of which is associated with a poor function of TSH receptor, the findings raise a possibility of involvement of factors including\n                    <jats:italic>Tpst2<\/jats:italic>\n                    in the insulin hyposecretion in\n                    <jats:italic>grt<\/jats:italic>\n                    mice.\n                  <\/jats:p>","DOI":"10.1677\/joe-09-0465","type":"journal-article","created":{"date-parts":[[2010,5,20]],"date-time":"2010-05-20T21:58:02Z","timestamp":1274392682000},"page":"195-204","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":18,"title":["Impaired insulin secretion from the pancreatic islets of hypothyroidal growth-retarded mice"],"prefix":"10.1530","volume":"206","author":[{"given":"Yusuke","family":"Taguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshie","family":"Tasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Terakado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Machida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/206\/2\/195.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/206\/2\/195.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:55:03Z","timestamp":1784555703000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/206\/2\/195-204\/22041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,20]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1677\/joe-09-0465","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,20]]}}}