{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:17:42Z","timestamp":1783678662820,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1953,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>1. Two in vitro tests are described for measuring the inhibitory potency of antithyroid drugs on enzymic and non-enzymic oxidative iodination of protein; one, a milk enzymic iodination test, and the other an enzyme-free peroxide iodination test.<\/jats:p>\n                  <jats:p>2. Five recognized antithyroid drugs have been tested: 2-thiouracil, 2-carbethoxythio-methyl-glyoxaline, potassium thiocyanate, resorcinol and sulphathiazole. By means of the milk enzymic test they could be ranged in order of potency, as indicated by the molar concentrations required for 50 % inhibition. They could also be separated into different types by the speed with which they pass from minimal to maximal inhibition with rising molar concentration.<\/jats:p>\n                  <jats:p>3. With the enzyme-free peroxide test, thiouracil, but not resorcinol, was found to be inert; with the enzymic test, both were nearly equivalent in potency.<\/jats:p>","DOI":"10.1677\/joe.0.0090224","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:41:39Z","timestamp":1229013699000},"page":"224-231","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":8,"title":["THE MODE OF ACTION OF ANTITHYROID DRUGS: RESULTS WITH TWO\n                    <i>IN VITRO<\/i>\n                    TESTS"],"prefix":"10.1530","volume":"9","author":[{"given":"W. R.","family":"PITNEY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. RUSSELL","family":"FRASER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/9\/2\/joe_9_2_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/9\/2\/224\/62319\/joe_9_2_011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/9\/2\/224\/62319\/joe_9_2_011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:55:56Z","timestamp":1783677356000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/9\/2\/224\/11006\/THE-MODE-OF-ACTION-OF-ANTITHYROID-DRUGS-RESULTS"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1953,4,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1953,4,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0090224","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1953,4,1]]}}}