{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:12:48Z","timestamp":1783678368295,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"4","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1967,4,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Uterine vascular permeability changes, measured quantitatively by trypan blue accumulation, and measurements of uterine water content, were used to study the postulated role of histamine as a mediator of oestrogen action. Histamine (H), oestradiol (E), 1\u00b73% NaCl solution, an antihistamine (AH\u2014diphenhydramine hydrochloride\u2014Benadryl) or xylene (X), was injected intraluminally into each uterine horn of ovariectomized rats. At intervals of 1\/4\u201324 hr. after treatment uterine vascular changes were determined by comparing the trypan blue concentration of treated uteri with the concentration in ovariectomized controls. In the 1\/4\u20131 hr. time periods 1\u00b70 mg. H and 0\u00b75\u20132\u00b75 mg. AH showed increases 2 to 6 times greater than the slight permeability change induced by 0\u00b704 \u03bcg. E or 1\u00b73% NaCl, and were similar to that evoked by the inflammatory tissue irritant xylene. The characteristic uterine permeability effect of oestrogen was evident at 4 hr. at which time H and AH produced similar responses. However, histological examination showed a complete loss of epithelium of the uterine lumen caused by 1\u00b70 mg. H, 0\u00b75\u20132\u00b75 mg. AH, and X during the first 4 hr. but only a partial loss with NaCl or E. When lower doses of histamine were administered, epithelial loss was reduced, and with 0\u00b71 mg. histamine epithelial loss, uterine permeability, and water content approached those of rats treated with the 1\u00b73% NaCl solution.<\/jats:p>","DOI":"10.1677\/joe.0.0370393","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:50:14Z","timestamp":1229014214000},"page":"393-NP","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":3,"title":["UTERINE CHANGES AFTER INTRALUMINAL ADMINISTRATION OF HISTAMINE AND OESTROGEN"],"prefix":"10.1530","volume":"37","author":[{"given":"HELENE C.","family":"CECIL","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"BITMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"J. A.","family":"HANNUM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LOIS","family":"TREZISE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/37\/4\/joe_37_4_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/37\/4\/393\/54318\/joe_37_4_005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/37\/4\/393\/54318\/joe_37_4_005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:14:53Z","timestamp":1783674893000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/37\/4\/393\/8370\/UTERINE-CHANGES-AFTER-INTRALUMINAL-ADMINISTRATION"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1967,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1967,4,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0370393","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1967,4,1]]}}}