{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:13:51Z","timestamp":1783678431677,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1968,1,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Adrenal tissue, largely composed of the definitive zone, from a newborn anencephalic infant, contained the following enzyme systems: (1) a \u03945-3\u03b2-hydroxysteroid dehydrogenase for pregnenolone, demonstrated by the conversion of [14C]pregnenolone to [14C]progesterone; (2) a C(17)-C(20) desmolase, and (3) a steroid 16\u03b1-hydroxylase, demonstrated by the conversion of [14C]pregnenolone to [14C]3\u03b2, 16\u03b1-dihydroxyandrost-5-en-17-one.<\/jats:p>\n                  <jats:p>The metabolites could not be separated from carrier steroids during sequential partition chromatography. [14C]Progesterone was identified by recrystallization to constant specific activity. [14C]3\u03b2, 16\u03b1-Dihydroxyandrost-5-en-17-one was identified by enzymatic conversion to [14C]16\u03b1-hydroxyoestrone followed by reduction to oestriol and determination of the specific activity of the oestriol after partition chromatography.<\/jats:p>\n                  <jats:p>It is suggested that these enzymes may play some part in the production of cortisol by the newborn anencephalic infant, and in the provision of precursors for placental oestriol production.<\/jats:p>","DOI":"10.1677\/joe.0.0400029","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:50:14Z","timestamp":1229014214000},"page":"29-35","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":11,"title":["THE CONVERSION OF PREGNENOLONE TO PROGESTERONE AND 16\u03b1-HYDROXYDEHYDROEPIANDROSTERONE\n                    <i>IN VITRO<\/i>\n                    BY ADRENAL TISSUE FROM A NEWBORN ANENCEPHALIC INFANT"],"prefix":"10.1530","volume":"40","author":[{"given":"M. M.","family":"SHAHWAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"OAKEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"STITCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/40\/1\/joe_40_1_003.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/40\/1\/29\/54968\/joe_40_1_003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/40\/1\/29\/54968\/joe_40_1_003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:24:35Z","timestamp":1783675475000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/40\/1\/29\/8585\/THE-CONVERSION-OF-PREGNENOLONE-TO-PROGESTERONE-AND"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1968,1,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0400029","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1968,1,1]]}}}