{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:13:54Z","timestamp":1783678434886,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1968,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hydroxylation at the angular C-19 methyl group is thought to be a necessary step for the biosynthesis of oestrogens since it is the first stage of aromatization (Meyer, 1955; Ryan, 1959).<\/jats:p>\n                  <jats:p>Griffiths (1963) found that the dose of metyrapone which produced an inhibition of 11\u03b2-hydroxylase activity in the adrenal of the golden hamster also produced a decrease in the activity of the 19-hydroxylase. This indicated the use of metyrapone as an inhibitor of oestrogen biosynthesis. F\u00f6ldes, Koref, Feh\u00e9r &amp; Steczek (1964) suggested that metyrapone affects the adrenal and the ovary; they reported a decrease in the excretion of oestrone, 17\u03b2-oestradiol and oestriol with a particularly marked decrease of the oestradiol fraction, both on the day of treatment and on the day after. The same authors refer to a simultaneous increase of androsterone and aetiocholanolone originating possibly from androst-4-ene-3,17-dione, the concentration of which may increase with the decreased formation of 19<\/jats:p>","DOI":"10.1677\/joe.0.0400253","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:50:14Z","timestamp":1229014214000},"page":"253-254","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":1,"title":["EFFECT OF METYRAPONE ON THE EXCRETION OF OESTROGEN IN MAN"],"prefix":"10.1530","volume":"40","author":[{"given":"A. E.","family":"ARG\u00dcELLES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"MART\u00cd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"SABORIDA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U. L.","family":"POGGI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/40\/2\/joe_40_2_013.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/40\/2\/253\/54812\/joe_40_2_013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/40\/2\/253\/54812\/joe_40_2_013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:21:52Z","timestamp":1783675312000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/40\/2\/253\/8526\/EFFECT-OF-METYRAPONE-ON-THE-EXCRETION-OF-OESTROGEN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1968,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1968,2,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0400253","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1968,2,1]]}}}