{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:15:34Z","timestamp":1783678534253,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1969,6,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Bovine growth hormone (BGH) digested with chymotrypsin showed a significant retention of biological activity after the hydrolysis of six bonds and the formation of 20% non-precipitable nitrogen.<\/jats:p>\n                  <jats:p>Disk electrophoresis of \u00bd and 3 hr. digests demonstrated complete loss of the major electrophoretic component of BGH with the appearance of one or more components of greater anodal mobility.<\/jats:p>\n                  <jats:p>Administration of the chymotryptic digests of BGH to three hypopituitary patients resulted in an anti-insulin response, aggravation of diabetes mellitus or anabolic effects.<\/jats:p>","DOI":"10.1677\/joe.0.0440255","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:50:14Z","timestamp":1229014214000},"page":"255-265","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":7,"title":["GROWTH HORMONE ACTIVITY IN MAN OF CHYMOTRYPTIC DIGESTS OF BOVINE GROWTH HORMONE"],"prefix":"10.1530","volume":"44","author":[{"given":"M.","family":"SONENBERG","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"DELLACHA","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. A.","family":"FREE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. C.","family":"NADLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/44\/2\/joe_44_2_010.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/44\/2\/255\/55977\/joe_44_2_010.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/44\/2\/255\/55977\/joe_44_2_010.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:40:48Z","timestamp":1783676448000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/44\/2\/255\/8941\/GROWTH-HORMONE-ACTIVITY-IN-MAN-OF-CHYMOTRYPTIC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,6,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1969,6,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0440255","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1969,6,1]]}}}