{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:15:37Z","timestamp":1783678537020,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1969,7,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>In a case of hydatidiform mole accompanied by theca lutein cysts there was a greatly increased urinary excretion of pregnanetriol. Incubation of the mole tissue with [4-14C]pregnenolone resulted in the formation of 17\u03b1-hydroxypregnenolone, progesterone, 16\u03b1-hydroxyprogesterone and 16\u03b2hydroxyprogesterone.<\/jats:p>\n                  <jats:p>Cholesterol, pregnenolone, 17\u03b1-hydroxypregnenolone, pregnanediol, pregnanetriol and androstenedione were isolated from both the mole tissue itself and from the ovarian cyst fluid. Progesterone and 17\u03b1-hydroxyprogesterone were characterized only from the cyst fluid. Greater quantities of the metabolic intermediates between pregnenolone and pregnanetriol were isolated from the cyst fluid than from the mole tissue.<\/jats:p>\n                  <jats:p>On the basis of these results it is concluded that although the mole tissue is active in steroid metabolism the increased urinary excretion of pregnanetriol is a function of the polycystic ovaries.<\/jats:p>","DOI":"10.1677\/joe.0.0440335","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:50:14Z","timestamp":1229014214000},"page":"335-348","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":7,"title":["STEROIDOGENESIS IN A CASE OF HYDATIDIFORM MOLE"],"prefix":"10.1530","volume":"44","author":[{"given":"J. R. T.","family":"COUTTS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. C.","family":"MACNAUGHTON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. E.","family":"ROSS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"WALKER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/44\/3\/joe_44_3_006.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/44\/3\/335\/55995\/joe_44_3_006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/44\/3\/335\/55995\/joe_44_3_006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:40:56Z","timestamp":1783676456000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/44\/3\/335\/8945\/STEROIDOGENESIS-IN-A-CASE-OF-HYDATIDIFORM-MOLE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,7,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1969,7,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0440335","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1969,7,1]]}}}