{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:16:00Z","timestamp":1783678560581,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1969,11,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Dogs were fed diets of high, suboptimal or low protein value (NDpCal% = 10, 7 or 5) from weaning at approximately 6 weeks of age. Immunoreactive plasma insulin levels were measured during intravenous glucose tolerance tests at 8, 13 and 20 weeks of age. In the dogs fed on diets of suboptimal or low protein value, the assimilation coefficient (K) increased within the first 2 weeks on diet, without any corresponding increase in insulin output. Later, as glucose tolerance tended to become impaired, the insulin output increased significantly. A significant increase in insulin response also occurred in dogs fed the high protein diet, at approximately 6 months of age, when the growth rate had slowed down. The increase in insulin response to i.v. glucose, observed in dogs fed the diets of low protein value, did not occur in animals which became marasmic through loss of appetite. Such animals had a very feeble insulin response. The findings are discussed in relation to human protein-calorie deficiency syndromes (kwashiorkor and marasmus).<\/jats:p>","DOI":"10.1677\/joe.0.0450375","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:50:14Z","timestamp":1229014214000},"page":"375-386","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":6,"title":["THE INSULINOGENIC RESPONSE TO INTRAVENOUS GLUCOSE IN DOGS FED DIETS OF DIFFERENT PROTEIN VALUE"],"prefix":"10.1530","volume":"45","author":[{"given":"C. R. C.","family":"HEARD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PAMELA A. J.","family":"HENRY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/45\/3\/joe_45_3_003.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/45\/3\/375\/56278\/joe_45_3_003.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/45\/3\/375\/56278\/joe_45_3_003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:44:15Z","timestamp":1783676655000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/45\/3\/375\/9035\/THE-INSULINOGENIC-RESPONSE-TO-INTRAVENOUS-GLUCOSE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,11,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1969,11,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0450375","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1969,11,1]]}}}