{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:12:57Z","timestamp":1783602777520,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1970,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Urinary oestrogens, pregnanediol and the 6-oxygenated metabolites of progesterone increase during normal pregnancy (Fotherby, James, Kamyab, Klopper &amp; Wilson, 1965). This report describes the excretion of the 6-oxygenated metabolites of progesterone, pregnanediol, oestrone, oestradiol and oestriol during phases of pregnancy where the normal processes regulating steroidogenesis were disturbed.<\/jats:p>\n                  <jats:p>Urinary steroids were estimated by the following methods: oestriol, Klopper &amp; Wilson (1962); oestrone and oestradiol, Brown (1955) slightly modified by Shearman (1964); pregnanediol, Klopper, Michie &amp; Brown (1955); 6-oxygenated progesterone metabolites, James &amp; Fotherby (1965).<\/jats:p>\n                  <jats:p>Corticotrophin (ACTH) 50 u., in 540 ml 0\u00b79% NaCl soin was administered i.v. to the mother over 8 h during a 12-h urine collection period. Dehydroepiandrosterone sulphate (DHAS) sodium salt (500 mg) was similarly administered. The subjects were volunteers and resided as hospital in-patients. Mrs A. was clinically normal (gestation 29\u201330 weeks) and received a DHAS infusion on 27\/vi. Mrs B. (33\u201337 weeks gestation) was carrying<\/jats:p>","DOI":"10.1677\/joe.0.0480467","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T16:50:14Z","timestamp":1229014214000},"page":"467-468","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":0,"title":["6-OXYGENATED PROGESTERONE METABOLITES AND THE REGULATION OF STEROIDOGENESIS IN LATE HUMAN PREGNANCY"],"prefix":"10.1530","volume":"48","author":[{"given":"J.","family":"JEFFERY","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. H.","family":"SWAPP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. R.","family":"WILSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"FOTHERBY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/48\/3\/joe_48_3_018.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/48\/3\/467\/57060\/joe_48_3_018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/48\/3\/467\/57060\/joe_48_3_018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:13:33Z","timestamp":1783599213000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/48\/3\/467\/9274\/6-OXYGENATED-PROGESTERONE-METABOLITES-AND-THE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,11,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1970,11,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0480467","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1970,11,1]]}}}