{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:13:53Z","timestamp":1783602833344,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,5,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Incubation of slices of adrenal tissue from a newborn anencephalic infant with [14C]pregnenolone and [3H]progesterone yielded radioactive testosterone, androst-4-ene-3,17-dione and 11\u03b2-hydroxyandrost-4-ene-3,17-dione which were characterized by reverse isotope dilution techniques. These findings indicate the presence of C(17)\u2014C(20) desmolase, steroid 11\u03b2-hydroxylase, 3\u03b2-hydroxysteroid dehydrogenase-isomerase and 17\u03b2-hydroxysteroid dehydrogenase enzymes in this tissue. Therefore, despite the deficient production of C19 3\u03b2-hydroxy-unsaturated steroids by the anencephalic foetus, as indicated by cord blood levels, a potential for synthesis of C19 3-oxo-4-unsaturated steroids has been demonstrated in vitro.<\/jats:p>","DOI":"10.1677\/joe.0.0500115","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:08:26Z","timestamp":1229015306000},"page":"115-122","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":2,"title":["ANDROGEN SYNTHESIS\n                    <i>IN VITRO<\/i>\n                    BY ADRENAL TISSUE FROM A NEWBORN ANENCEPHALIC INFANT"],"prefix":"10.1530","volume":"50","author":[{"given":"M. M.","family":"SHAHWAN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"OAKEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. R.","family":"STITCH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/50\/1\/joe_50_1_009.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/50\/1\/115\/57356\/joe_50_1_009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/50\/1\/115\/57356\/joe_50_1_009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:18:14Z","timestamp":1783599494000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/50\/1\/115\/9383\/ANDROGEN-SYNTHESIS-IN-VITRO-BY-ADRENAL-TISSUE-FROM"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,5,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1971,5,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0500115","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1971,5,1]]}}}