{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:14:26Z","timestamp":1783602866356,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1971,11,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>The metabolism of [3H]pregnenolone and [3H]dehydroepiandrosterone ([3H]DHA) by tissue from the separated zones and whole adrenal glands from newborn anencephalic infants was investigated.<\/jats:p>\n                  <jats:p>Pregnenolone was metabolized by the whole gland homogenates mainly to pregnenolone sulphate and unconjugated 17\u03b1-hydroxypregnenolone and also to small amounts of DHA and dehydroepiandrosterone sulphate (DHAS). DHA was metabolized by the whole gland homogenates mainly to androstenedione and DHAS and small amounts of 11\u03b2-hydroxyandrostenedione.<\/jats:p>\n                  <jats:p>Adrenal gland tissue from a 42-week-old anencephalic infant containing three histologically distinct zones in the adult cortex in addition to residual foetal zone had sulphokinase, 17\u03b1-hydroxylase, 17\u201320 lyase and 3\u03b2-hydroxy-steroid dehydrogenase\/\u03944,5 unsaturated isomerase activity in each of these zones. These enzymes were also present in the adrenal adult zone of another anencephalic infant.<\/jats:p>\n                  <jats:p>Omission of ATP from the incubation medium greatly reduced the conversion of DHA to DHAS in the homogenates and separated zones.<\/jats:p>\n                  <jats:p>These results are discussed in relation to oestrogen biosynthesis in anencephaly and to foetal 4-en-3-oxosteroid synthesis in utero.<\/jats:p>","DOI":"10.1677\/joe.0.0510533","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:08:26Z","timestamp":1229015306000},"page":"533-NP","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":4,"title":["METABOLISM OF PREGNENOLONE AND DEHYDROEPIANDROSTERONE BY HOMOGENIZED TISSUE FROM THE SEPARATED ZONES AND WHOLE ADRENAL GLANDS FROM NEWBORN ANENCEPHALIC INFANTS"],"prefix":"10.1530","volume":"51","author":[{"given":"B. A.","family":"COOKE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"SHIRLEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"DOBBIE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PATRICIA D.","family":"TAYLOR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/51\/3\/joe_51_3_014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/51\/3\/533\/57841\/joe_51_3_014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/51\/3\/533\/57841\/joe_51_3_014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:24:37Z","timestamp":1783599877000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/51\/3\/533\/9557\/METABOLISM-OF-PREGNENOLONE-AND"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,11,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1971,11,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0510533","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1971,11,1]]}}}