{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:16:35Z","timestamp":1783599395021,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,2,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>The clearance of synthetic luteinizing hormone releasing hormone (LH-RH) after intravenous injection has been investigated in man. Thirteen tests were performed in ten subjects, four of whom were normal, the other six had proven disease of the hypothalamo-pituitary region. The rate of disappearance of LH-RH from the circulation could be represented as a double exponential with half-times of the two components of 5\u00b73 and 27\u00b74 min respectively. The initial volume of distribution was 11\u00b71 \u00b1 1\u00b76 (s.d.) 1 and the metabolic clearance rate 1480 \u00b1 170 (s.d.) 1\/day. There was no difference in any of these parameters between normal and abnormal subjects. Between 0\u00b775 and 2\u00b78% of the injected dose was excreted in the urine within 8 h, of which 48% was excreted in the first hour. The daily production rates of LH-RH were calculated from the urinary excretion rates; these gave higher results than production rates calculated from the blood metabolic clearance rate. Possible reasons for this are discussed.<\/jats:p>","DOI":"10.1677\/joe.0.0600305","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:08:26Z","timestamp":1229015306000},"page":"305-314","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":39,"title":["BLOOD AND URINE CLEARANCE OF LUTEINIZING HORMONE RELEASING HORMONE IN MAN MEASURED BY RADIOIMMUNOASSAY"],"prefix":"10.1530","volume":"60","author":[{"given":"S. L.","family":"JEFFCOATE","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. H.","family":"GREENWOOD","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. T.","family":"HOLLAND","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/60\/2\/joe_60_2_012.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/60\/2\/305\/59991\/joe_60_2_012.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/60\/2\/305\/59991\/joe_60_2_012.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:32:39Z","timestamp":1783596759000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/60\/2\/305\/10271\/BLOOD-AND-URINE-CLEARANCE-OF-LUTEINIZING-HORMONE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,2,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0600305","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1974,2,1]]}}}