{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:25:39Z","timestamp":1783599939230,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,9,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>The urinary excretion of thyroid-stimulating hormone (TSH) has been measured by double antibody radioimmunoassay after concentration by dialysis followed by lyophilization. Among 30 normal subjects, the excretion was 5\u00b76 \u00b1 0\u00b731 (s.e.m.) \u03bcu.\/h. No diurnal variation nor differences between sexes were discerned. In 14 primary hypothyroid subjects the urinary excretion was raised (P &amp;lt; 0\u00b7001) to 25\u00b71 \u00b1 3\u00b73 \u03bcu.\/h. In 14 hyperthyroid and 7 hypopituitary subjects subnormal levels of 2\u00b76 \u00b1 0\u00b72 and 2\u00b75 \u00b1 0\u00b722 \u03bcu.\/h (P &amp;lt; 0\u00b7001) respectively, were found. Serum and urinary TSH concentrations were measured before, during and after an infusion of human pituitary TSH (MRC 70\/9) in two subjects and showed a correlation.<\/jats:p>\n                  <jats:p>Urinary TSH measurement is thus a good discriminant between normal and hyperthyroid or hypopituitary patients.<\/jats:p>","DOI":"10.1677\/joe.0.0620645","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:08:26Z","timestamp":1229015306000},"page":"645-655","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":12,"title":["CONCENTRATIONS OF IMMUNOREACTIVE THYROTROPHIC HORMONE IN URINE OF NORMAL SUBJECTS, PATIENTS WITH THYROID DISORDERS AND HYPOPITUITARISM, AND AFTER INFUSION OF HUMAN THYROTROPHIC HORMONE"],"prefix":"10.1530","volume":"62","author":[{"given":"S. F.","family":"KUKU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"HARSOULIS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"YOUNG","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. R.","family":"FRASER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/62\/3\/joe_62_3_020.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/62\/3\/645\/60942\/joe_62_3_020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/62\/3\/645\/60942\/joe_62_3_020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:45:38Z","timestamp":1783597538000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/62\/3\/645\/10591\/CONCENTRATIONS-OF-IMMUNOREACTIVE-THYROTROPHIC"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,9,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0620645","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1974,9,1]]}}}