{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:16:04Z","timestamp":1789514164751,"version":"build-2803163510"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1975,10,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Specific radioimmunoassays were used to assess the content of LH, FSH, the gonadotrophin \u03b1-subunit and the LH \u03b2-subunit in four adult, 19 normal foetal pituitary glands (9\u00b75\u201332 weeks of gestation) and a pituitary extract from an anencephalic foetus (36 weeks). The hormones and subunits were further identified by column chromatography on Sephadex G-100. All pituitary glands contained free \u03b1-subunit and intact LH but the \u03b1-subunit:LH ratio was significantly higher in the early foetal pituitaries (9\u00b75\u201316 weeks) than in the four adult pituitaries. Only small or undetectable amounts of LH \u03b2-subunit and 'undetectable' FSH were found in these early foetal pituitaries (9\u00b75\u201311\u00b75 weeks). The concentration of intact hormones or subunits in the pituitaries showed no significant sex difference in any of the groups. In contrast to these results, only \u03b1-subunit was detectable in the pituitary of the anencephalic foetus.<\/jats:p>\n                  <jats:p>For 14 early foetuses (age of gestation 10\u201316 weeks) the serum levels of LH\u2013HCG, FSH, and \u03b1-subunit in the circulation were significantly higher than in 26 foetuses at term (37\u201341 weeks). On the basis of these results a theory for the development of the gonadotrophin secretion from the foetal pituitary gland is outlined.<\/jats:p>","DOI":"10.1677\/joe.0.0670049","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:08:26Z","timestamp":1229015306000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":42,"title":["IDENTIFICATION OF HUMAN LUTEINIZING HORMONE, FOLLICLE-STIMULATING HORMONE, LUTEINIZING HORMONE \u03b2-SUBUNIT AND GONADOTROPHIN \u03b1-SUBUNIT IN FOETAL AND ADULT PITUITARY GLANDS"],"prefix":"10.1530","volume":"67","author":[{"given":"C.","family":"HAGEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"McNEILLY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","updated-by":[{"DOI":"10.1677\/joe.0.0680488-a","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[1976,3,1]],"date-time":"1976-03-01T00:00:00Z","timestamp":194486400000}}],"container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/67\/1\/joe_67_1_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/67\/1\/49\/131671\/joe_67_1_005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/67\/1\/49\/131671\/joe_67_1_005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T12:02:02Z","timestamp":1783598522000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/67\/1\/49\/23181\/IDENTIFICATION-OF-HUMAN-LUTEINIZING-HORMONE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,10,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,10,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0670049","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1975,10,1]]}}}