{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:17:47Z","timestamp":1783610267562,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,7,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>The quantities of nine corticosteroids in 24 h urine samples collected by pregnant women (nine with normal foetuses and nine with anencephalic foetuses) were measured after hydrolysis with \u03b2-glucuronidase and separation by paper chromatography. The excretion (\u03bcmol\/24 h, mean \u00b1 s.d.) of pregnanetriol (0\u00b785 \u00b1 0\u00b717), 3\u03b1,17\u03b1-dihydroxy-5\u03b2-pregnan-20-one 17\u03b1-hydroxypregnanolone, 0\u00b755 \u00b1 0\u00b717), 3\u03b1,17\u03b1,21-trihydroxy-5\u03b2-pregnan-20-one (tetrahydro-11-deoxycortisol, 0\u00b717 \u00b1 0\u00b714) and tetrahydrocorticosterone (0\u00b765 \u00b1 0\u00b726) by women with an anencephalic foetus was significantly lower (P &amp;lt; 0\u00b701 or &amp;lt;0\u00b705) than the excretion of these compounds by women with a normal foetus (pregnanetriol, 2\u00b742 \u00b1 0\u00b762; 17\u03b1-hydroxypregnanolone, 2\u00b772 \u00b1 0\u00b769; tetrahydro-11-deoxycortisol, 0\u00b756 \u00b1 0\u00b737; tetrahydrocorticosterone, 1\u00b795 \u00b1 0\u00b794). These differences suggest that the adrenal of the normal foetus contributes to the quantity of pregnanetriol, 17\u03b1-hydroxypregnanolone, tetrahydro-11-deoxycortisol and tetrahydrocorticosterone in maternal urine. The excretion of tetrahydrocortisol, tetrahydrocortisone, tetrahydrodeoxycorticosterone, cortol and cortolone were similar in both groups of subjects.<\/jats:p>\n                  <jats:p>No evidence was obtained therefore to indicate the secretion of cortisol or deoxycorticosterone by the foetal zone of the adrenal of the undisturbed human foetus in late gestation.<\/jats:p>","DOI":"10.1677\/joe.0.0700117","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:22:29Z","timestamp":1229016149000},"page":"117-126","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":8,"title":["CORTICOSTEROID PRODUCTION BY THE HUMAN FOETUS: EVIDENCE FROM ANALYSIS OF URINE FROM WOMEN PREGNANT WITH A NORMAL OR AN ANENCEPHALIC FOETUS"],"prefix":"10.1530","volume":"70","author":[{"given":"MARION L.","family":"CAWOOD","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. F.","family":"HEYS","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. E.","family":"OAKEY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/70\/1\/joe_70_1_013.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/70\/1\/117\/131640\/joe_70_1_013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/70\/1\/117\/131640\/joe_70_1_013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:50:39Z","timestamp":1783608639000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/70\/1\/117\/23167\/CORTICOSTEROID-PRODUCTION-BY-THE-HUMAN-FOETUS"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,7,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0700117","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1976,7,1]]}}}