{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:18:27Z","timestamp":1783610307959,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1976,10,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>Continuous infusions of luteinizing hormone releasing hormone (LH-RH) into phenobarbitone-treated long-term ovariectomized rats, resulted in patterns of LH secretion which were determined by the blood LH-RH concentration. Infusions of 52 ng LH-RH\/h caused steadily increasing plasma LH levels, which stabilized after about 2 h of infusion and were maintained for the rest of the experiment (9 h).<\/jats:p>\n                  <jats:p>A similar course of plasma LH concentration was observed as a result of infusions of 104 ng LH-RH\/h, though in this case LH concentrations reached higher levels than those induced by infusion of 52 ng LH-RH\/h. Higher rates of LH-RH infusion (208 and 416 ng\/h), however, induced clear-cut LH peaks, which reached their maximal plasma values after 2\u20133 h of infusion and then declined again until, at the end of the experiment, they were only slightly higher than the LH levels induced by infusions of 52 ng LH-RH\/h.<\/jats:p>\n                  <jats:p>A similar series of LH-RH infusions given to ovariectomized rats pretreated with oestradiol benzoate during 3 days (the rats were injected daily with 7 \u03bcg steroid), produced a highly augmented response of the pituitary gland, but all LH-RH concentrations infused induced rather sharp LH peaks, reaching their maximum after 2\u20133 h of infusion. After 5 h of infusion the descending parts of all these peaks appeared to converge.<\/jats:p>\n                  <jats:p>In both control and oestradiol benzoate-pretreated rats there appeared to be a linear relationship between the logarithm of the blood LH-RH concentration and the maximal plasma LH values on one hand, and the amount of LH secreted during the first 5 h of infusion on the other. Furthermore, it appeared that the longer the period of oestrogen action, the more the response of the pituitary gland to a certain dose of LH-RH was enhanced.<\/jats:p>","DOI":"10.1677\/joe.0.0710001","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:22:29Z","timestamp":1229016149000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":9,"title":["SECRETION OF LUTEINIZING HORMONE CAUSED BY CONTINUOUS INFUSIONS OF LUTEINIZING HORMONE RELEASING HORMONE IN THE LONG-TERM OVARIECTOMIZED RAT: EFFECT OF OESTROGEN PRETREATMENT"],"prefix":"10.1530","volume":"71","author":[{"given":"G. A.","family":"SCHUILING","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. P.","family":"GNODDE","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/71\/1\/joe_71_1_001.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/71\/1\/1\/132247\/joe_71_1_001.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/71\/1\/1\/132247\/joe_71_1_001.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:57:42Z","timestamp":1783609062000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/71\/1\/1\/23353\/SECRETION-OF-LUTEINIZING-HORMONE-CAUSED-BY"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,10,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,10,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0710001","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1976,10,1]]}}}