{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:12:54Z","timestamp":1783613574418,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The inhibitory effect of some gestagens and calusterone on the binding of oestradiol-17\u03b2 to its specific uterine receptors has been investigated in intact rats. Progesterone, medrogestone, clogestone, medroxyprogesterone acetate and calusterone reduce the specific oestradiol\u2013 receptor interaction in vitro; this effect is dose-dependent and does not differ significantly from one drug to the other. A more relevant decrease in the amount of oestradiol-17\u03b2 bound to specific receptors has been observed with calusterone. Progesterone, clogestone, medrogestone, medroxyprogesterone acetate and calusterone given orally induce a marked decrease (between 30 and 70% depending on the dose) in the binding capacity of oestradiol-17\u03b2 to specific uterine receptors in vivo. Results from a Scatchard plot analysis suggest that the interference with the binding of oestradiol-17\u03b2 caused by both progestogens and calusterone is due to a non-competitive interaction.<\/jats:p>","DOI":"10.1677\/joe.0.0770049","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:22:29Z","timestamp":1229016149000},"page":"49-55","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":16,"title":["INTERFERENCE OF GESTAGENS AND ANDROGENS WITH RAT UTERINE OESTROGEN RECEPTORS"],"prefix":"10.1530","volume":"77","author":[{"given":"F.","family":"DI CARLO","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"CONTI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"REBOANI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/77\/1\/joe_77_1_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/77\/1\/49\/133413\/joe_77_1_005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/77\/1\/49\/133413\/joe_77_1_005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:14:39Z","timestamp":1783610079000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/77\/1\/49\/23729\/INTERFERENCE-OF-GESTAGENS-AND-ANDROGENS-WITH-RAT"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,4,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1978,4,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0770049","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1978,4,1]]}}}