{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:13:32Z","timestamp":1783613612260,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1978,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>University Department of Obstetrics and Gynaecology, Kandang Kerbau Hospital for Women, Singapore 8, Republic of Singapore<\/jats:p>\n                  <jats:p>(Revised manuscript received 1 September 1978)<\/jats:p>\n                  <jats:p>Evidence from various laboratories indicates that molar trophoblasts may be biosynthetically very active in vitro and capable of bringing about several steroidal transformations (Van Leusden &amp; Siemerink, 1969; Coutts &amp; MacNaughton, 1971). However, a lack of incorporation of labelled acetate into pregnenolone and progesterone by molar vesicles has been observed by Van Leusden (1971) and Van Leusden &amp; Villee (1966). Van Leusden (1971) also failed to demonstrate the conversion of [5-3H]mevalonate into sterols, cholesterol and steroids by these vesicles. These observations could be interpreted as indicating that the molar vesicles lack or possess only a very limited capacity to biosynthesize cholesterol from acetate and mevalonate. There also remains the distinct possibility that the vesicles are deficient in the C-20,22-desmolase complex that cleaves the sterol molecule into pregnenolone and<\/jats:p>","DOI":"10.1677\/joe.0.0790409","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:22:29Z","timestamp":1229016149000},"page":"409-410","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":1,"title":["ABILITY OF MOLAR TROPHOBLASTS TO SPLIT THE SIDE-CHAIN OF [26-14C]CHOLESTEROL\n                    <i>IN VITRO<\/i>"],"prefix":"10.1530","volume":"79","author":[{"given":"R.","family":"GUNASEGARAM","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L.","family":"PEH","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. C. T.","family":"CHEW","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M. M.","family":"KARIM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. S.","family":"RATNAM","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/79\/3\/joe_79_3_025.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/79\/3\/409\/133799\/joe_79_3_025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/79\/3\/409\/133799\/joe_79_3_025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:21:00Z","timestamp":1783610460000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/79\/3\/409\/23868\/ABILITY-OF-MOLAR-TROPHOBLASTS-TO-SPLIT-THE-SIDE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,12,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0790409","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1978,12,1]]}}}