{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:13:59Z","timestamp":1783613639177,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1979,7,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>The synthesis of glucocorticoids and mineralocorticoids in vitro was studied in an adrenocortical carcinoma after ablation from an 11\u00b75-year-old boy. This patient had been unsuccessfully treated with high doses of o,p\u2032-dichlorodiphenyldichloroethane (o,p\u2032-DDD) and aminoglutethimide. These in-vitro results were compared with those obtained with another adrenocortical carcinoma removed from a 26-year-old woman who had received no preoperative treatment. The sensitivity of these adrenocortical carcinomas to o,p\u2032-DDD, aminoglutethimide and 2-(p-aminophenyl)-2-phenylethylamine (SKF 12185) was investigated. Synthesis of cortisol (47%) and corticosterone (45%) in control incubations showed that 11\u03b2-hydroxylase activity was not affected by the treatment. This explains the raised level of plasma cortisol in the treated child. All three compounds inhibited both 11\u03b2-hydroxylase and 18-hydroxylase activities up to 95%, depending on the inhibitor. This study shows (a) an inhibitory effect of o,p\u2032-DDD on the steroidogenesis of an adrenocortical carcinoma in vitro, an effect not previously reported in man or laboratory animals, and (b) the in-vitro efficacy of o,p\u2032-DDD and aminoglutethimide on corticosteroidogenesis by a carcinoma unresponsive to treatment in vivo. This discrepancy between data obtained in vivo and in vitro could possibly be explained by either an insufficient ratio of ingested dose: tumour mass, or a malabsorption of the drugs in this patient.<\/jats:p>","DOI":"10.1677\/joe.0.0820087","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:22:29Z","timestamp":1229016149000},"page":"87-94","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":13,"title":["GLUCOCORTICOID AND MINERALOCORTICOID PATHWAYS IN TWO ADRENOCORTICAL CARCINOMAS: COMPARISON OF THE EFFECTS OF\n                    <i>o,p<\/i>\n                    \u2032-DICHLORODIPHENYLDICHLOROETHANE, AMINOGLUTETHIMIDE AND 2-\n                    <i>p<\/i>\n                    -AMINOPHENYL-2-PHENYLETHYLAMINE\n                    <i>IN VITRO<\/i>"],"prefix":"10.1530","volume":"82","author":[{"given":"YVAN","family":"TOUITOU","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDR\u00c9","family":"BOGDAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ANDR\u00c9","family":"AUZEBY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEAN-PAUL","family":"DOMMERGUES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/82\/1\/joe_82_1_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/82\/1\/87\/134208\/joe_82_1_011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/82\/1\/87\/134208\/joe_82_1_011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:26:28Z","timestamp":1783610788000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/82\/1\/87\/23987\/GLUCOCORTICOID-AND-MINERALOCORTICOID-PATHWAYS-IN"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1979,7,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0820087","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1979,7,1]]}}}