{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:14:24Z","timestamp":1783613664479,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1980,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Male Wistar rats were fed a lithium diet for 2\u20133 months producing marked polyuria (&amp;gt; 75 ml\/100 g in 24 h) and a plasma Li concentration of 0\u00b77 mmol\/l. In acute experiments animals were anaesthetized with 5-ethyl-5-(1-methylpropyl)-2-thiobarbituric acid and infused with hypotonic glucose\u2013saline (15 ml\/h). Addition of prostaglandin A2 (PGA2; 0\u00b72 ng\/min) for 180 min to the infusate did not restore the impaired antidiuretic response to arginine-vasopressin (AVP) whether this agent was infused continuously (150 \u03bcu.\/min) or given as bolus injections (2500 \u03bcu.). In long-term experiments animals were kept in metabolism cages and Alzet osmotic minipumps were implanted for intravenous infusion of drugs at 1 \u03bcl\/h. Again, PGA2 infusion at 0\u00b72 ng\/min failed to restore the impaired antidiuretic response to AVP (150 \u03bcu.\/min). It was therefore concluded that in rats with severe polyuria induced by long-term administration of lithium, infusion of PGA2 at 0\u00b72 ng\/min cannot restore the impaired response to antidiuretic hormone as has been reported by others.<\/jats:p>","DOI":"10.1677\/joe.0.0840459","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:22:29Z","timestamp":1229016149000},"page":"459-465","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":0,"title":["FAILURE OF INFUSION OF PROSTAGLANDIN A2 TO RESTORE THE RESPONSE TO ANTIDIURETIC HORMONE IN RATS WITH POLYURIA INDUCED BY LITHIUM"],"prefix":"10.1530","volume":"84","author":[{"given":"STEN","family":"CHRISTENSEN","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/84\/3\/joe_84_3_016.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/84\/3\/459\/134773\/joe_84_3_016.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/84\/3\/459\/134773\/joe_84_3_016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:34:36Z","timestamp":1783611276000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/84\/3\/459\/24164\/FAILURE-OF-INFUSION-OF-PROSTAGLANDIN-A2-TO-RESTORE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1980,3,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0840459","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1980,3,1]]}}}