{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:15:46Z","timestamp":1783613746665,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Male and female Wistar rats were made hyperprolactinaemic by grafting two pituitary glands of litter-mate donors under the kidney capsule at 30 days of age. Other animals were sham-operated at the same age to serve as controls. Plasma levels of prolactin, LH and FSH were measured by double-antibody radioimmunoassay. Basal preoperative prolactin levels of \u223c 10 ng\/ml increased after the transplantation in both male and female rats, reaching values of \u223c 180 ng\/ml. Levels of LH were significantly reduced in these hyperprolactinaemic rats, whereas an increase in FSH values was seen. After administration of LH releasing hormone (LH-RH) a reduced LH response was seen but there was no response of FSH to LH-RH or even a decrease in FSH values. Prolactin levels were also reduced by LH-RH injection. Although an increase in prolactin levels was observed in control animals after a challenge with oestradiol benzoate, reduced increments were seen in experimental animals. The positive feedback effect of oestradiol benzoate on LH in females was reduced in pituitary-grafted rats but a potentiation of the FSH positive feedback could be clearly detected. This study suggests a dissociation of LH and FSH regulation in hyperprolactinaemia.<\/jats:p>","DOI":"10.1677\/joe.0.0900041","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:45:06Z","timestamp":1229017506000},"page":"41-51","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":41,"title":["DISSOCIATION IN THE REGULATION OF LUTEINIZING HORMONE AND FOLLICLE-STIMULATING HORMONE IN A HYPERPROLACTINAEMIC RAT MODEL: INTERRELATIONSHIPS BETWEEN GONADOTROPHIN AND PROLACTIN CONTROL"],"prefix":"10.1530","volume":"90","author":[{"given":"J. A. F.","family":"TRESGUERRES","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. I.","family":"ESQUIFINO","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/90\/1\/joe_90_1_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/90\/1\/41\/135709\/joe_90_1_005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/90\/1\/41\/135709\/joe_90_1_005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:49:01Z","timestamp":1783612141000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/90\/1\/41\/24477\/DISSOCIATION-IN-THE-REGULATION-OF-LUTEINIZING"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,7,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0900041","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1981,7,1]]}}}