{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:15:55Z","timestamp":1783613755138,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Globulin preparations from the sera of 104 untreated patients with Graves's disease have been tested for their thyroid-stimulating antibody (TSAb) activities. Eighty-one of the samples (78%) were positive in the assay for the thyrotrophin-binding inhibitory immunoglobulins, 48 samples (46%) contained human thyroid adenyl cyclase stimulators (HTACS) and 71 (68%) contained human thyroid stimulators (HTS) measured as stimulation of colloid droplet formation in human thyroid slices. All 104 samples were positive in one or other of the assays, 29 (28%) were positive in all three assays and 38 (37%) in two.<\/jats:p>\n                  <jats:p>All samples were tested for their specific TSH-binding characteristics, 40 (38%) possessed 'B-type' binding sites (previously characterized as TSH-binding sites with low affinity but high capacity for the ligand) but the remaining 64 samples (62%) were no different from normal control samples and had 'A-type' binding sites (high affinity but low capacity binding sites for TSH). Samples without detectable thyrotrophin-binding inhibitory immunoglobulin did not contain B-type TSH-binding globulins. Globulins exhibiting B-type binding were more active in the HTACS and HTS assays.<\/jats:p>\n                  <jats:p>The B-type TSH-binding globulins have a characteristic, dose-dependent reducing effect on the human thyroid adenyl cyclase stimulation by TSH whereas A-type globulins do not. Globulins exhibiting B-type TSH-binding may therefore have a significant effect on assays for TSAb activities. The methods used to measure TSAb have been reviewed from this point of view.<\/jats:p>","DOI":"10.1677\/joe.0.0920175","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:45:06Z","timestamp":1229017506000},"page":"175-184","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":22,"title":["THYROID-STIMULATING ANTIBODIES IN GRAVES'S DISEASE AND THE EFFECT OF THYROTROPHIN-BINDING GLOBULINS ON THEIR DETERMINATION"],"prefix":"10.1530","volume":"92","author":[{"given":"J.","family":"BI\u0301RO\u0301","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/92\/2\/joe_92_2_002.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/92\/2\/175\/135862\/joe_92_2_002.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/92\/2\/175\/135862\/joe_92_2_002.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T15:51:23Z","timestamp":1783612283000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/92\/2\/175\/24528\/THYROID-STIMULATING-ANTIBODIES-IN-GRAVES-S-DISEASE"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,2,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0920175","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1982,2,1]]}}}