{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:16:59Z","timestamp":1783613819191,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The effects of cyproheptadine, desmethylcyproheptadine, serotonin, \u03b3-amino-butyric acid (GABA) and sodium valproate were studied on ACTH secretion by cultured non-enzymatically dispersed pituitary tumour cells from three patients with Nelson's syndrome. Cyproheptadine (1\u201310 \u03bcmol\/l) and desmethylcyproheptadine (1\u201310 \u03bcmol\/l) suppressed ACTH secretion significantly (P &amp;lt;0\u00b701), while serotonin (10 \u03bcmol\/l) did not have a direct effect. Serotonin was also not able to reverse the (desmethyl)cyproheptadine-mediated inhibition of ACTH release. Sodium valproate and GABA did not exert a direct effect on hormone release by these cultured pituitary tumour cells. It is suggested that cyproheptadine-mediated inhibition of ACTH release in Nelson's syndrome might be effected by a direct non-serotonin-related effect on the pituitary tumour, while sodium valproate suppresses ACTH release by a suprahypophysial action.<\/jats:p>","DOI":"10.1677\/joe.0.0960401","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:45:06Z","timestamp":1229017506000},"page":"401-406","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":18,"title":["Effect of cyproheptadine, desmethylcyproheptadine, \u03b3-amino-butyric acid and sodium valproate on adrenocorticotrophin secretion by cultured pituitary tumour cells from three patients with Nelson's syndrome"],"prefix":"10.1530","volume":"96","author":[{"given":"S. W. J.","family":"Lamberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Verleun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. G.","family":"Bons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Uitterlinden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Oosterom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/96\/3\/joe_96_3_005.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/96\/3\/401\/136813\/joe_96_3_005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/96\/3\/401\/136813\/joe_96_3_005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:05:26Z","timestamp":1783613126000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/96\/3\/401\/24836\/Effect-of-cyproheptadine-desmethylcyproheptadine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,3,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0960401","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1983,3,1]]}}}