{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:17:14Z","timestamp":1783613834128,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The synthetic androgen 17\u03b2-hydroxy-17\u03b1-methyl-estra-4,9,11-triene-3-one (methyltrienolone, R 1881) binds specifically and with high affinity to androgen receptors and is presumably not metabolized into either the less potent androgens or into oestrogens. Because of these intrinsic properties, R 1881 can be used to investigate the possibility of a direct androgen involvement in the development of sexual behaviour. Females, at birth, were implanted with silicone elastomer capsules containing R 1881, testosterone, dihydrotestosterone or cholesterol for 10 days, or given daily injections of 100 \u03bcg hormone for 5 days. Neonatal treatment with R 1881 inhibited the capacity of female rats to show female mating behaviour when given ovarian hormones in adulthood; both implants and injections caused a similar reduction in receptive and proceptive behaviours. Testosterone, given as implants, caused almost complete defeminization, while injecting the hormone had a partial inhibition on mating responses. Dihydrotestosterone had no appreciable effect upon the development of behaviour. Thus, an androgen, R 1881, which is presumed not to be aromatized to oestrogens, has the potential to cause defeminization of mating and proceptive behaviour in female rats.<\/jats:p>","DOI":"10.1677\/joe.0.0980431","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:45:06Z","timestamp":1229017506000},"page":"431-438","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":5,"title":["Effects of 17\u03b2-hydroxy-17\u03b1-methyl-estra-4,9,11-triene-3-onene-3-one (R 1881): evidence for direct involvement of androgens in the defeminization of behaviour in rats"],"prefix":"10.1530","volume":"98","author":[{"given":"K. L.","family":"Olsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/98\/3\/joe_98_3_017.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/98\/3\/431\/137114\/joe_98_3_017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/98\/3\/431\/137114\/joe_98_3_017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T16:10:13Z","timestamp":1783613413000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/98\/3\/431\/24941\/Effects-of-17-hydroxy-17-methyl-estra-4-9-11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,9,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.0980431","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1983,9,1]]}}}