{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:23:39Z","timestamp":1783596219899,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,4,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>In order to investigate whether the impaired GH secretion associated with hypothyroidism and hyperthyroidism is due to a hypothalamic or a pituitary disorder, we have studied plasma GH responses to GH-releasing factor (1\u201329) (GRF) in euthyroid, hypothyroid and hyperthyroid rats. Hypothyroid rats showed a significant (P&amp;lt; 0\u00b7001) reduction in GH responses to GRF (5 \u03bcg\/kg) at 5 min (350 \u00b1 35 vs 1950 \u00b1260 \u03bcg\/l), 10 min (366\u00b166 vs 2320 \u00b1 270 \u03bcg\/l) and 15 min after GRF injection (395 \u00b1 72 vs 1420 \u00b1 183 \u03bcg\/l; means \u00b1 s.e.m.) compared with euthyroid rats. Hyperthyroid rats showed a significant (P&amp;lt;0\u00b705) decrease in GH responses to 5 \u03bcg GRF\/kg after 30 min (200\u00b114 vs 325 \u00b1 35 \u03bcg\/l) but not at other time-points, or after the administration of 1 \u03bcg GRF\/kg. These data indicate that in hypothyroidism and perhaps hyperthyroidism there is an alteration in the responsiveness of the somatotroph to GRF administration.<\/jats:p>\n                  <jats:p>J. Endocr (1986) 109, 53\u201356<\/jats:p>","DOI":"10.1677\/joe.0.1090053","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:52:58Z","timestamp":1229017978000},"page":"53-56","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":12,"title":["Growth hormone responses to growth hormone-releasing factor (1\u201329) in euthyroid, hypothyroid and hyperthyroid rats"],"prefix":"10.1530","volume":"109","author":[{"given":"C.","family":"Dieguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Foord","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. D.","family":"Rodriguez-Arnao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gomez-Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. F.","family":"Scanlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/109\/1\/joe_109_1_008.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/109\/1\/53\/95722\/joe_109_1_008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/109\/1\/53\/95722\/joe_109_1_008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:37:58Z","timestamp":1783593478000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/109\/1\/53\/15541\/Growth-hormone-responses-to-growth-hormone"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,4,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1090053","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1986,4,1]]}}}