{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:22:35Z","timestamp":1783596155830,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,5,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>We examined whether cyclic AMP (cAMP) affects the incorporation of [3H]thymidine into cartilage cells and, if so, whether this action could be related to the inhibitory effect of glucocorticoid hormones on the growth of ossifying cartilage. Incorporation of [3H]thymidine into trichloroacetic acid-precipitable material by mouse cartilage was measured concomitantly with the concentration of cAMP. Dexamethasone (1 \u03bcmol\/l) significantly (P &amp;lt; 0\u00b705) depressed the incorporation of [3H]thymidine. The cAMP analogue 8-bromo-cAMP (0\u00b701\u20131 mmol\/l) also depressed the incorporation of the radionucleotide in a dose-dependent fashion. When various concentrations of 8-bromo-cAMP were added with dexamethasone (1 \u03bcmol\/l), no apparent changes took place compared with the effect of dexamethasone alone. The phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (0\u00b72-1 mmol\/l) elicited an inhibitory effect on [3H]thymidine incorporation and a stimulatory influence on cartilage cAMP concentrations. Dexamethasone, at doses (0\u00b701\u20131 \u03bcmol\/l) causing significant inhibition of [3H]thymidine incorporation, failed to increase cartilage levels of cAMP. It seems, therefore, that the depressive effect of dexamethasone on [3H]thymidine incorporation in condylar cartilage is not mediated through an increase of cAMP in the tissue.<\/jats:p>\n                  <jats:p>J. Endocr. (1986) 109, 209\u2013213<\/jats:p>","DOI":"10.1677\/joe.0.1090209","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:52:58Z","timestamp":1229017978000},"page":"209-213","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":4,"title":["Dexamethasone and 8-bromo-cyclic AMP depress the incorporation of [3H]thymidine into mouse condylar cartilage by different pathways"],"prefix":"10.1530","volume":"109","author":[{"given":"Z.","family":"Kraiem","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Maor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Silbermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/109\/2\/joe_109_2_011.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/109\/2\/209\/95726\/joe_109_2_011.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/109\/2\/209\/95726\/joe_109_2_011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:37:52Z","timestamp":1783593472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/109\/2\/209\/15537\/Dexamethasone-and-8-bromo-cyclic-AMP-depress-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,5,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,5,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1090209","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1986,5,1]]}}}