{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:24:05Z","timestamp":1783596245498,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,1,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>SR-202 is a non-iodinated potential lipid-altering agent. When administered (100 mg) three times per day for 3 days to six euthyroid subjects it was associated with a 30 \u00b1 3% (mean \u00b1 s.e.m.) fall in 3,3\u2032,5-tri-iodothyronine(T3)(P &amp;lt; 0\u00b7001), a reciprocal 104 \u00b1 14% rise in 3,3\u2032,5\u2032-tri-iodothyronine (reverse T3, rT3) (P &amp;lt; 0\u00b701), and a 37 \u00b1 7% rise in thyroxine (T4) (P &amp;lt; 0\u00b7001). Basal and TRH-stimulated TSH did not change. These results suggested that SR-202 was acting as an inhibitor of the peripheral monodeiodination of T4 to T3.<\/jats:p>\n                  <jats:p>During a second study the same subjects received the same dose of SR-202 for a further 3 days following 15 days of progressive substitutive treatment with l-T4, which they continued to take at 200 \u03bcg\/day until the end of the study. Despite higher levels of thyroid hormones in the substituted subjects, similar results were observed, serum T3 falling by 40 \u00b1 2% (P &amp;lt; 0\u00b7001), serum rT3 and T4 rising by 168 \u00b1 24% (P &amp;lt; 0\u00b701) and 37 \u00b1 9% (P &amp;lt; 0\u00b701) respectively. These changes provide compelling evidence that SR-202 is an inhibitor of the peripheral conversion of T4 to T3 that acts on thyroid hormone metabolism without provoking a counter-regulatory pituitary response. It might prove to be a useful tool for the clinical investigation of thyroid function.<\/jats:p>\n                  <jats:p>J. Endocr. (1987) 112, 171\u2013175<\/jats:p>","DOI":"10.1677\/joe.0.1120171","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:52:58Z","timestamp":1229017978000},"page":"171-175","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":1,"title":["Interference of dimethyl \u03b1-(dimethoxyphosphinyl)\n                    <i>p<\/i>\n                    -chlorobenzyl phosphate (SR-202) in thyroid hormone. metabolism: evidence of inhibition of monodeiodination"],"prefix":"10.1530","volume":"112","author":[{"given":"C.","family":"Liniger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pometta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. G.","family":"Burger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/112\/1\/joe_112_1_024.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/112\/1\/171\/96603\/joe_112_1_024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/112\/1\/171\/96603\/joe_112_1_024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:49:09Z","timestamp":1783594149000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/112\/1\/171\/15828\/Interference-of-dimethyl-dimethoxyphosphinyl-p"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1120171","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1987,1,1]]}}}