{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:24:46Z","timestamp":1783596286745,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The effect of oestradiol-17\u03b2 on the hypothalamo-pituitary axis of intact adult male rats was studied. A single injection of oestradiol did not change the serum LH response to gonadotrophin-releasing hormone (GnRH) 48 h or 7 days after the injection, while administration of oestrogen over 66 days suppressed basal serum LH to &amp;lt;3\u00b71 \u03bcg\/l and did not enhance the LH response to GnRH at any time.<\/jats:p>\n                  <jats:p>Treatment of ovariectomized rats with oestradiol capsules, however, enhanced the LH response to GnRH on days 3 and 14 of the treatment as compared with the control group (P&amp;lt;0\u00b702 and P&amp;lt;0\u00b705 respectively). Long-term treatment with oestradiol suppressed intrapituitary LH and FSH contents as well as pituitary GnRH receptors (P&amp;lt;0\u00b70004, P&amp;lt;0\u00b7005 and P&amp;lt;0\u00b7001 respectively), whereas serum and intrapituitary prolactin levels were increased. To exclude the possible inhibitory effect of hyperprolactinaemia on LH responsiveness to GnRH, oestradiol-implanted rats were treated with bromocriptine. This prevented the rise in serum prolactin, but failed to enhance the LH response to GnRH.<\/jats:p>\n                  <jats:p>Neither short- nor long-term treatment with oestradiol given under conditions shown to be effective in female animals stimulated the hypothalamo-pituitary-gonadotrophin axis in adult male rats.<\/jats:p>\n                  <jats:p>J. Endocr. (1987) 114,95\u2013101<\/jats:p>","DOI":"10.1677\/joe.0.1140095","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:52:58Z","timestamp":1229017978000},"page":"95-101","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":3,"title":["Effect of oestrogen treatment on gonadotroph function in adult male rats"],"prefix":"10.1530","volume":"114","author":[{"given":"G.","family":"Saade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. R.","family":"London","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. N.","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/114\/1\/joe_114_1_014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/114\/1\/95\/96733\/joe_114_1_014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/114\/1\/95\/96733\/joe_114_1_014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:51:58Z","timestamp":1783594318000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/114\/1\/95\/15889\/Effect-of-oestrogen-treatment-on-gonadotroph"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,7,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1140095","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1987,7,1]]}}}