{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T11:24:57Z","timestamp":1783596297816,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Oral contraceptives reduce menstrual pain but the interaction with vasopressin and prostaglandin F2\u03b1, two uterine stimulants related to the condition, is unknown. Ten women with a history of moderate to severe dysmenorrhoea were studied. Repeated blood samples were taken during a first menstrual cycle without treatment, during the first 21 days of a second cycle when they received an oral contraceptive (150 \u03bcg levonorgestrel and 30 \u03bcg ethynyloestradiol) and on the first or second day of the bleeding following hormonal withdrawal. Measurements were made of plasma concentrations of arginine vasopressin, 15-keto-13,14-dihydroprostaglandin F2\u03b1, oestradiol-17\u03b2, progesterone, ethynyloestradiol, levonorgestrel, FSH, LH and prolactin, and serum osmolality was measured. Seven of the women rated their discomfort as moderate to severe on the first two menstruations, but as none or light at the withdrawal bleeding; with the rating scale for degree of pain that was used, this decrease in pain was significant (P&amp;lt; 0\u00b7001). The plasma concentration of vasopressin in these seven women showed significant variation, with the highest concentrations being obtained at the beginning of the two painful menstruations (3\u00b776 \u00b1 0\u00b776 and 1\u00b775 \u00b1 0\u00b730 (s.e.m.) pmol\/l and at ovulation in the control cycle (1\u00b791\u00b10\u00b758 pmol\/l). During treatment the concentrations were consistently low, except on the first day of withdrawal bleeding (2\u00b733\u00b10\u00b735 pmol\/l). The concentrations of the prostaglandin F2\u03b1 metabolite showed less variation, but again the values at withdrawal bleeding (271 \u00b1 39 pmol\/l) were not different from those obtained over the painful menstruations (255 \u00b1 24 and 217 \u00b1 25 pmol\/l. The plasma concentrations of ovarian and adenohypophysial hormones, as well as osmolality, were normal throughout. The remaining three women had no, or only slight, menstrual pain in the control cycle and no menstrual peaks in the concentration of vasopressin or prostaglandin F metabolite. The present results gave no evidence for a reduced release of vasopressin and\/or prostaglandin F2\u03b1 that could explain the beneficial effect of oral contraceptives in dysmenorrhoea. Instead, it is possible that this effect is due to a decreased sensitivity of the uterus to these factors.<\/jats:p>\n                  <jats:p>J. Endocr. (1987) 115,355\u2013361<\/jats:p>","DOI":"10.1677\/joe.0.1150355","type":"journal-article","created":{"date-parts":[[2008,12,11]],"date-time":"2008-12-11T17:52:58Z","timestamp":1229017978000},"page":"355-361","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":22,"title":["Plasma concentrations of vasopressin and a prostaglandin F2\u03b1 metabolite in women with primary dysmenorrhoea before and during treatment with a combined oral contraceptive"],"prefix":"10.1530","volume":"115","author":[{"given":"A.","family":"Hauksson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"\u00c5kerlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. L.","family":"Forsling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kindahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/115\/2\/joe_115_2_023.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/115\/2\/355\/97193\/joe_115_2_023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article-pdf\/115\/2\/355\/97193\/joe_115_2_023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T10:58:02Z","timestamp":1783594682000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/joe\/article\/115\/2\/355\/16023\/Plasma-concentrations-of-vasopressin-and-a"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,11,1]]}},"URL":"https:\/\/doi.org\/10.1677\/joe.0.1150355","relation":{},"ISSN":["1479-6805","0022-0795"],"issn-type":[{"value":"1479-6805","type":"electronic"},{"value":"0022-0795","type":"print"}],"subject":[],"published":{"date-parts":[[1987,11,1]]}}}